The use of alcohol-derived fuels produced from renewable resources is an effective method to reduce dependence on petroleum. However, alcohols can improve the combustion process by changing the fuel chemistry. In this way, performance, emission, mechanical vibration and noise values can be improved in diesel engines. In this study; New fuel forms (D90E10, D90IB10, D80E10IB10, D77.5E10IB10DEE2.5, 75E10IB10DEE5) were formed by mixing ethanol, isobutanol and diethyl ether alcohols with diesel fuel in certain proportions. The fuels generated was used in experiments. The studies were conducted with four different loads (%25, 50, 75, and 100) at a constant speed (2800 rpm). The optimum fuel mixture was determined by examining the engine performance, exhaust emissions, mechanical vibrations and noise data obtained in the experiments. When the most important data output of the test results is evaluated; In tests with D75E10IB10DEE5 fuel, it was determined that smoke emissions were reduced by 24.6% and mechanical vibrations by 14.2% compared to standard diesel fuel at full load.