This research investigates the influence of project team interaction, guidance, feedback, and material quality within the Learning Management System (LMS) on the development of critical thinking skills and the ability to engage in lifelong learning. Partial least squares analysis was employed to test hypotheses using data from participants in the Catholic Religious Teacher Professional Education program at the Educational Institution for Education Personnel Santo Yakobus Merauke-South Papua through simple random sampling. The research results indicate that project team interaction, guidance, feedback, and material quality within the Learning Management System (LMS) significantly and positively contribute to developing critical thinking skills and lifelong self-directed learning. The managerial implications of this study underscore the importance of creating high-quality learning materials in the LMS and providing practical guidance and feedback to students to support the development of both skills. The theoretical implications of this research strengthen the understanding of the relationship between project team interaction, guidance, feedback, material quality in the LMS, critical thinking skills, and self-directed learning. Theories in education and psychology can be utilized as a foundation for designing more effective interventions to enhance both skills.