Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines

Vida, Gabriella; Sulyok, E.; Ertl, Tibor; Martens‐Lobenhoffer, Jens; Bode‐Böger, Stefanie M.

doi:10.1111/j.1442-200x.2012.03605.x

Cited by 14 publications

(14 citation statements)

References 30 publications

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“…In late pregnancy, physiologically increased ADMA levels thus help prepare the uterine muscle fibers for the higher contractile activity that is necessary for successful delivery by antagonizing NO-induced uterine relaxation. This is reflected by the higher ADMA level after cesarean birth compared with vaginal birth [36]. After birth, ADMA levels fall, which may contribute to decreased NO production and bioavailability in neonatal vascular beds [36].…”

Section: Roles Of No and Adma In Normal Pregnanciesmentioning

confidence: 99%

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Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming

Huang

Hsieh

Chang

et al. 2012

IJMS

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Nitric oxide (NO) regulates placental blood flow and actively participates in trophoblast invasion and placental development. Asymmetric dimethylarginine (ADMA) can inhibit NO synthase, which generates NO. ADMA has been associated with uterine artery flow disturbances such as preeclampsia. Substantial experimental evidence has reliably supported the hypothesis that an adverse in utero environment plays a role in postnatal physiological and pathophysiological programming. Growing evidence suggests that the placental nitrergic system is involved in epigenetic fetal programming. In this review, we discuss the roles of NO and ADMA in normal and compromised pregnancies as well as the link between placental insufficiency and epigenetic fetal programming.

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Section: Roles Of No and Adma In Normal Pregnanciesmentioning

confidence: 99%

“…This is reflected by the higher ADMA level after cesarean birth compared with vaginal birth [36]. After birth, ADMA levels fall, which may contribute to decreased NO production and bioavailability in neonatal vascular beds [36]. …”

Section: Roles Of No and Adma In Normal Pregnanciesmentioning

confidence: 99%

Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming

Huang

Hsieh

Chang

et al. 2012

IJMS

View full text Add to dashboard Cite

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“…Moreover, the list of clinical entities in which altered ADMA levels are found in the pediatric population continues to grow and includes conditions such as hypertension, hypercholesterolemia, chronic kidney disease or diabetes mellitus (see [ 17 ] for review). However, the information on dimethylarginines in the peri-/neonatal period is much scarce [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Herein, we analyzed the plasma concentrations of ADMA, SDMA, l -arginine, and citrulline in a cohort of 130 VLBW preterm infants.…”

Section: Resultsmentioning

confidence: 99%

Plasma Levels of Dimethylarginines in Preterm Very Low Birth Weight Neonates: Its Relation with Perinatal Factors and Short-Term Outcome

Moonen

Huizing

Cavallaro

et al. 2014

IJMS

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Endogenously produced inhibitors of nitric oxide (NO) synthase, in particular asymmetric dimethylarginine (ADMA), are currently considered of importance in various disease states characterized by reduced NO availability. We investigated the association between plasma levels of ADMA, symmetric dimethylarginine (SDMA), l-arginine, and citrulline and perinatal factors and outcome in 130 preterm (gestational age ≤30 weeks) very low birth weight (VLBW, <1500 g) infants. Plasma samples were collected 6–12 h after birth. We did not find significant correlations between ADMA, SDMA, l-arginine, and citrulline levels and gestational age or birth weight. However, the arginine:ADMA ratio (AAR, a better indicator of NO availability than either arginine or ADMA separately) was positively correlated with gestational age. ADMA and arginine levels were not significantly different between males and females but males showed a negative correlation between ADMA levels and gestational age. Perinatal factors such as preeclampsia, chrorioamnionitis, prolonged rupture of membranes, or form of delivery did not significantly alter dimethylarginine levels or AAR. In contrast, the AAR was significantly reduced in the infants with respiratory distress, mechanical ventilation, and systemic hypotension Therefore, our data suggest that altered NO availability may play a role in the respiratory and cardiovascular adaptation in preterm VLBW infants.

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“…There was no difference between the two groups in terms of hemoglobin values in our study. The study by Vida et al found that levels of asymmetric dimethylarginine were increased in the samples taken from the umbilical vein and artery and from peripheral vein on day 30, with an associated decrease in the production and bioavailability of nitric oxide, and concluded that CS may cause endothelial dysfunction as a result of this, highlighting the need for further studies concerning this issue 23 . It was reported that systemic endothelial function is more closely correlated with the progression of preclinical carotid artery disease, and endothelial function is more closely correlated with carotid IMT than with conventional risk factors 24 .…”

Section: Discussionmentioning

confidence: 99%

Sezaryen ile Doğmuş Genç Erişkinlerin Kardiyovasküler Sistem Özellikleri

Akşıt¹,

Gazı²,

Kırılmaz³

et al. 2020

Namık Kemal Tıp Dergisi

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Aim: Currently, the prevalence of caesarean section (CS) has been increasing at an alarming rate across the world. In parallel with the increasing rate of CS, it is reported that there is an increasing prevalence of obesity, autoimmune and allergic diseases. The purpose of the present study is to analyse whether the cardiovascular system characteristics of young adults born by CS are different from those of young adults born by vaginal delivery (VD). Materials and Methods: A total of 112 participants were included in the study (40 CS group vs 82 VD ie control group). Transthoracic echocardiography and carotid Doppler ultrasonography were performed to the participants. In addition, participants were evaluated with a 24-hour ECG recording. Results: Tricuspid E wave, tricuspid A wave and tricuspid E/A ratio were lower in the CS group compared with the control group (57.6±8.6 vs. 72.4±10.3, p<0.001; 46.7±8.8 vs. 50.6±8.9, p=0.04; 1.2±0.14 vs 1.45±0.88, p<0.001). Epicardial fat tissue thickness were higher in the CS group compared with the control group (4.8±1.3 vs. 3.1±0.8, p<0.001). Conclusion: The results of this study show that cardiovascular system features of the young adults born by CS are different from those born by VD. Further follow-up studies are needed to understand whether these findings will subsequently result in cardiovascular diseases.

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Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines

Abstract: ADMA level falls after both vaginal and cesarean birth, whereas SDMA level does not. The higher ADMA level after cesarean birth compared with vaginal birth may contribute to decreased nitric oxide production and bioavailability in neonatal vascular beds.

Cited by 14 publications

References 30 publications

Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming

Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming

Plasma Levels of Dimethylarginines in Preterm Very Low Birth Weight Neonates: Its Relation with Perinatal Factors and Short-Term Outcome

Sezaryen ile Doğmuş Genç Erişkinlerin Kardiyovasküler Sistem Özellikleri

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