Birth defects of 1,397 newborns conceived by in vitro fertilization/intracytoplasmic sperm injection and embryo transfer

Birth defects after assisted reproductive technologies in China: analysis of 15,405 offspring in seven centers (2004 to 2008)

“…This frequency was not significantly different from that recorded with use of similar criteria, in the 2008 China annual report of birth defects (1.35%) (5), or in other national compilations (6, 7) The frequency of birth defects after ICSI trended higher than that after IVF alone (1.P¼.47). Our findings overall were similar to the smaller, yet only other study from China (Guangzhou), by Chen et al(8), who found 18 birth defects (1.31%) among 1,279 infants: the frequency was 0.93% in IVF-ET and 2.49% in ICSI-ET.…”