Birth outcomes and background exposures to select elements, the Longitudinal Investigation of Fertility and the Environment (LIFE)

Bloom, Michael S.; Louis, Germaine M. Buck; Sundaram, Rajeshwari; Maisog, José M.; Steuerwald, Amy J.; Parsons, Patrick J.

doi:10.1016/j.envres.2015.01.008

Cited by 49 publications

(39 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean age of the mothers was 29 years, the mean pre-pregnancy BMI was 23.1 kg/m 2 , the mean estimated gestational length was 39.7 weeks, 50% of women have at least university education, 53.8% of babies were males, and the mean birth length for all babies was 51.4 cm. The mean birth weight of the babies in our study was comparable with those reported elsewhere [23,30,35,38,45,46]. A total of 3.4% of the new-borns were below the criterion for "low birth weight" of 2,500 g [17], and 0.2% of new-borns were below 1,500 g, considered as a "very low birth weight" [47].…”

Section: Discussionsupporting

confidence: 73%

“…Exposure to Pb was found to be associated with birth weight either negatively [37,38], or insignificantly [34][35][36]. Non-significant correlations have been observed for Hg in maternal blood [35,36,39].…”

Section: Introductionmentioning

confidence: 92%

“…Xu et al suggested that the presence of As in maternal blood has a negative influence on birth weight and on gestational age in boys [31]. Studies investigating the effects of Cd exposure during pregnancy have been in conclusive: some studies [32][33][34] report negative associations, some positive [35], and others no association at all [36,37]. Exposure to Pb was found to be associated with birth weight either negatively [37,38], or insignificantly [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Jagodic¹,

Tratnik²,

Mazej³

et al. 2017

JHS

View full text Add to dashboard Cite

Abstract:The objective of the present study was to evaluate the relation between maternal blood levels of selected toxic and potentially toxic elements (manganese (Mn), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd), lead (Pb) and mercury (Hg)) and birth weight of their new-borns in a Slovenian population, taking into account maternal socio-demographic characteristics and dietary habits. 535 women from 12 regions of Slovenia were recruited at delivery. Maternal blood was collected at 1.5 months after birth. Associations between birth weight and a) predictors obtained through the questionnaires and b) levels of selected elements were tested using bivariate tests and multiple linear regression. Multiple regression models revealed maternal age as an additional predictor for birth weight and confirmed pre-pregnancy body mass, estimated gestational age and gender of the baby as the main predictors for birth weight. Mn in maternal blood was significantly and positively associated with birth weight. The positive association observed between birth weight and Mn in maternal blood could be explained by the essentiality of Mn in foetal development as an important cofactor in enzyme reactions in bone formation and in metabolic regulation for amino acid, lipid, protein and carbohydrate levels.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Jagodic¹,

Tratnik²,

Mazej³

et al. 2017

JHS

View full text Add to dashboard Cite

show abstract

“…Although sperm has been traditionally considered vehicle only for the delivery of the paternal genome upon fertilization, compelling animal data demonstrate that paternal nutritional manipulation during adulthood can alter sperm epigenetic marks (Lambrot et al, 2013; Wei et al, 2014) and noncoding RNA (Sharma et al, 2016) that may affect offspring health and development. Despite the lack of mechanistic data, a growing body of human observational studies show that preconception exposures may be associated with adverse reproductive health (Bae et al, 2015; Bloom et al, 2015a; Murphy et al, 2010; Robledo et al, 2015; Smarr et al, 2016). Most notably are results indicating that male partner urinary concentrations of MMP, MnBP, and MBzP were associated with a 20% reduction in fecundity as measured by time-to-pregnancy in U.S. couples (Buck Louis et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Urinary phthalate and phthalate alternative metabolites and isoprostane among couples undergoing fertility treatment

Olmsted

Cantonwine

et al. 2017

Environmental Research

View full text Add to dashboard Cite

Background Epidemiological data suggest associations between phthalate exposures to a variety of adverse reproductive outcomes including reduced sperm quality and reproductive success. While mechanisms of these associations are not fully elucidated, oxidative stress has been implicated as a potential mediator. We examined associations of urinary metabolites of phthalates and phthalate alternative plasticizers with oxidative stress among couples seeking fertility treatment. Methods Seventeen urinary plasticizer metabolites and 15-F2t isoprostane, a biomarker of oxidative stress, were quantified in spot samples from 50 couples seeking fertility treatment who enrolled in the Sperm Environmental Epigenetics and Development Study during 2014-2015. Results In multivariable analyses, percent change in isoprostane was positively associated with interquartile range increases for the oxidative metabolites of di-2-ethylhexyl phthalate, [mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP; 20.0%, p=0.02), mono-2-ethyl-5-oxohexyl phthalate (MEOHP; 24.1%, p=0.01), and mono-2-ethyl-5-carboxypentyl phthalate (MECPP; 24.1%, p=0.004)], mono-isobutyl phthalate (MiBP; 17.8%, p=0.02), mono-hydroxyisobutyl phthalate (MHiBP; 27.5%, p=0.003), and cyclohexane-1,2-dicarboxylic acid mono-hydroxy-isononyl ester (MHINCH; 32.3%, p=0.002). Stratification of participants by sex revealed that isoprostane was positively associated with MHiBP (41.4%, p=0.01) and monocarboxy-isononyl phthalate (MCNP; 26.0%, p=0.02) among females and MEOHP (35.8%, p=0.03), MiBP (29.2%, p=0.01), MHiBP (34.7%, p=0.007) and MHINCH (49.0%, p=0.002) among males. Conclusions Our results suggest that exposure to phthalates and phthalate replacements are associated with higher levels of oxidative stress in a sex-specific manner. Additional studies are needed to replicate our findings and to examine the potential health implications of the use of phthalates and alternative phthalates in consumer end products.

show abstract

“…Other studies have found adverse associations of maternal B‐Cd with SGA and/or birthweight in models adjusted for smoking 14, 15, 16. Conversely, other studies have found no associations7, 9, 12, 30 or even beneficial associations31 with birthweight or SGA in models adjusted or stratified for smoking, even when mean or median maternal B‐Cd levels were high (>1 μg/L) 10, 32, 33. There is greater consensus for other birth outcomes (birth length or crown–heel length, head circumference, gestational age, preterm birth), with most studies finding no associations (see Table S5).…”

Section: Commentsmentioning

confidence: 97%

Moderate Prenatal Cadmium Exposure and Adverse Birth Outcomes: a Role for Sex‐Specific Differences?

Taylor

Golding

Emond

2016

Paediatric Perinatal Epid

View full text Add to dashboard Cite

Background/AimStudies on the effects of moderate prenatal exposure to cadmium (Cd) on birth outcomes have been contradictory and it has been suggested that effects may be partly masked by sex‐specific effects. Our aim was to examine the association of Cd exposure in a large group of pregnant women with birth outcomes in the whole group of participants and by sex.MethodsPregnant women were enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood samples for singleton pregnancies with a live birth were analysed for Cd (n = 4191). Data collected on the infants included anthropometric variables and gestational age at delivery. Data were analysed using SPSS v18.ResultsThere were adverse associations of maternal blood Cd level with birthweight (unstandardized B coefficient −62.7 g, 95% CI −107.0, −18.4) and crown–heel length (−0.28 cm, 95% CI −0.48, −0.07) in adjusted regression models. On stratification by sex, maternal blood Cd level was adversely associated with birthweight (−87.1 g, 95% CI −144.8, −29.4), head circumference (−0.22 cm, 95% CI −0.39, −0.04), and crown–heel length (−0.44 cm, 95% CI −0.71, −0.18) in girls but not in boys in adjusted regression models.ConclusionIn these pregnant women with moderate prenatal Cd exposure there evidence of adverse associations with birth anthropometry variables in the whole group. However, there was evidence of associations with anthropometric variables in girls that were not evident in boys. Sex‐specific effects require further investigation in large cohorts as a possible contributor to the lack of associations generally found in mixed‐sex studies.

show abstract

Birth outcomes and background exposures to select elements, the Longitudinal Investigation of Fertility and the Environment (LIFE)

Cited by 49 publications

References 74 publications

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Urinary phthalate and phthalate alternative metabolites and isoprostane among couples undergoing fertility treatment

Moderate Prenatal Cadmium Exposure and Adverse Birth Outcomes: a Role for Sex‐Specific Differences?

Contact Info

Product

Resources

About