Birth outcomes in women with eating disorders in the Norwegian Mother and Child cohort study (MoBa)

Bulik, Cynthia M.; Holle, Ann Von; Siega‐Riz, Anna Maria; Torgersen, Leila; Lie, Kari Kveim; Hamer, Robert M.; Berg, Cecilie Knoph; Sullivan, Patrick F.; Reichborn‐Kjennerud, Ted

doi:10.1002/eat.20578

Cited by 101 publications

(178 citation statements)

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“…[36][37][38][39] Eating disorders during pregnancy and postpartum For many reasons, women with a lifetime ED history face unique challenges throughout pregnancy and the postpartum period. 5,[11][12][13]15,40 Although some women experience remission during pregnancy, 11 others report that pregnancy exacerbates ED symptoms and can lead to greater dietary restraint, poor nutrition, and increased purging behavior.…”

Section: Introductionmentioning

confidence: 99%

“…11,41 Moreover, perinatal complications associated with a lifetime ED diagnosis include an increased risk for hyperemesis, 13,42 smoking during pregnancy, 43 lower birth weight, and birth defects such as cleft palate and neural tube defects, microcephaly, preterm delivery, and cesarean delivery. 12,16,40,[44][45][46][47] Trauma and abuse history in eating disorders and perinatal depression Women with lifetime histories of EDs are also more likely to report a history of childhood sexual abuse and physical abuse compared with women with no ED history. 48,49 Although both childhood sexual abuse [50][51][52][53][54][55] and physical abuse 49,56,57 occur in individuals with EDs, they are best viewed as nonspecific risk factors for the development of psychopathology.…”

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confidence: 99%

“…[66][67][68][69][70][71] Perinatal depression and eating disorder comorbidity Perinatal depression is common in women with an ED history. [10][11][12][13][14][15][16][17] 75 …”

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confidence: 99%

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Eating Disorders and Trauma History in Women with Perinatal Depression

Meltzer‐Brody

Zerwas

Leserman

et al. 2011

Journal of Women's Health

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Objective: Although the prevalence of perinatal depression (depression occurring during pregnancy and postpartum) is 10%, little is known about psychiatric comorbidity in these women. We examined the prevalence of comorbid eating disorders (ED) and trauma history in women with perinatal depression. Methods: A research questionnaire was administered to 158 consecutive patients seen in a perinatal psychiatry clinic during pregnancy (n = 99) or postpartum (n = 59). Measures included Structured Clinical Interview for DSM (SCID) IV-based questions for lifetime eating psychopathology and assessments of comorbid psychiatric illness including the State/Trait Anxiety Inventory (STAI), Patient Health Questionnaire (PHQ-9), Edinburgh Postnatal Depression Scale (EPDS), and Trauma Inventory. Results: In this cohort, 37.1% reported a putative lifetime ED history; 10.1% reported anorexia nervosa (AN), 10.1% reported bulimia nervosa (BN), 10.1% reported ED not otherwise specified-purging subtype (EDNOS-P), and 7.0% reported binge eating disorder (BED). Women with BN reported more severe depression (EPDS score, 19.1, standard deviation [SD 4.3], p = 0.02; PHQ-severity 14.5, SD 7.4, p = 0.02) than the referent group of women with perinatal depression and no ED history (EPDS 13.3, SD = 6.1; PHQ 9.0, SD = 6.2). Women with AN were more likely to report sexual trauma history than the referent group (62.5% vs. 29.3%, p < 0.05), and those with BN were more likely report physical (50.0%, p < 0.05) and sexual (66.7%, p < 0.05) trauma histories. Conclusions: ED histories were present in over one third of admissions to a perinatal psychiatry clinic. Women with BN reported more severe depression and histories of physical and sexual trauma. Screening for histories of eating psychopathology is important in women with perinatal depression.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Eating Disorders and Trauma History in Women with Perinatal Depression

Meltzer‐Brody

Zerwas

Leserman

et al. 2011

Journal of Women's Health

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“…To explain why the season-of-birth effects found in BN were 6 months out-of-phase to our SAD data, more information on maternal eating disorders, food intake in pregnancy, birth weights, early feeding patterns, and the growth trajectories of our probands would be of great interest (Stewart et al, 1987;Treasure and Russell, 1988;Conti et al, 1998;Bulik et al, 1999Bulik et al, , 2009Sollid et al, 2004). Unfortunately, these variables were not included in the current protocol.…”

Section: Discussionmentioning

confidence: 92%

A Season-of-Birth/DRD4 Interaction Predicts Maximal Body Mass Index in Women with Bulimia Nervosa

Levitan

Kaplan

Davis

et al. 2010

Neuropsychopharmacol

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We have earlier reported that season of birth interacts with the hypofunctional 7-repeat (7R) allele of the dopamine-4 receptor gene (DRD4) to promote weight gain and obesity in women with seasonal affective disorder (SAD). This study examined whether this gene-environment interaction influences body weight regulation in women with bulimia nervosa (BN). In 188 female probands with BN, we performed an analysis of covariance predicting maximum lifetime body mass index (BMI) using season-of-birth, DRD4 genotype (7R present/absent), and past history of anorexia nervosa (yes/no) as independent variables, and age at maximum weight as the co-variate. Consistent with our SAD study, the birth-season x DRD4 interaction was a significant predictor of maximal BMI. Although in SAD, the spring-birth/7R+ group had markedly elevated maximal BMIs and high rates of obesity, in this BN sample, the fall-birth/7R+ group exhibited the highest BMI values (N=17: mean maximal BMI=28.2 kg/m(2) (SE 0.9) vs 25.2 kg/ m(2) (SE 0.3) for all other probands combined (N=171); p=0.002). The lifetime rate of obesity (BMI>30) was also higher in the fall-birth/7R+ vs 'other' group (29.9 vs 8.8%, respectively, p=0.008). These data offer further evidence that season of birth interacts with the 7R allele of DRD4 to influence body weight regulation in female overeating populations.

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“…[6][7][8][9][10][11][12][13][14] Though eating disorders (diagnostic criteria, Table 1) can present throughout the female life-course (clinical presentations, Table 2), pregnancy and the post-partum period are particularly high-risk times for relapse. Studies of pregnant women with a history of eating disorders demonstrate three periods of elevated risk: (1) the initial diagnosis of pregnancy, (2) early in the second trimester (coinciding with pregnancy ''show'') and (3) the post-partum period.…”

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confidence: 99%

Screening for Eating Disorders in Pregnancy: How Uniform Screening During a High-Risk Period Could Minimize Under-Recognition

Hawkins

Gottlieb

2013

Journal of Women's Health

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Eating disorders in the United States are on the rise, disproportionally afflict reproductive-age women, and can affect mortality rates as high as those in major depression. (1-3) Though studies have characterized associations of eating disorders with numerous adverse maternal and fetal outcomes, a paucity of studies have addressed diagnosis and management of eating disorders in pregnancy. (4-6) The present work synthesizes current literature to demonstrate how providers can improve identification by capitalizing on this high-risk period.

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Birth outcomes in women with eating disorders in the Norwegian Mother and Child cohort study (MoBa)

Cited by 101 publications

References 53 publications

Eating Disorders and Trauma History in Women with Perinatal Depression

Eating Disorders and Trauma History in Women with Perinatal Depression

A Season-of-Birth/DRD4 Interaction Predicts Maximal Body Mass Index in Women with Bulimia Nervosa

Screening for Eating Disorders in Pregnancy: How Uniform Screening During a High-Risk Period Could Minimize Under-Recognition

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