Birth size and cancer prognosis: a systematic review and meta-analysis

Sharma, Shantanu; Kohli, Charu; Johnson, Linda; Bennet, Louise; Brusselaers, Nele; Nilsson, Peter M.

doi:10.1017/s2040174419000631

Cited by 8 publications

(5 citation statements)

References 24 publications

(79 reference statements)

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“…Furthermore, birth size has been also shown to be positively related with estradiol level in adulthood [18,32,33]. Birth weight was also found to be positively related with breast cancer risk in women ( [2,15,26,52]; however see for contradictory results: [70]). The suggested mechanism for this is life-time exposure to high levels of estradiol [60].…”

Section: Introductionmentioning

confidence: 99%

Birth size and morphological femininity in adult women

2020

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Background: Women's morphological femininity is perceived to develop under the influence of sex hormones and to serve as a cue of estradiol level, fertility and health in mating context. However, as the studies on direct relationship between femininity and sex steroid levels have reported mixed results, it is still not well understood what factors contribute to inter-women variation in morphological femininity. Epidemiological studies show that indicators of adverse conditions during intrauterine growth and development in utero, such as low birthweight or relative thinness at birth, influence women's physiology ovarian functioning and may be associated with lifetime exposure to estradiol in women. Thus, here we tested if birth parameters are also related with the level of morphological femininity in adult women. Results: One hundred sixty-five healthy women of mean age 28.47 years (SD = 2.39) participated in the study. Facial femininity was estimated based on facial width-to-height ratio (fWHR) and facial shape sexual dimorphism measured in the photos. Body femininity was estimated based on waist-to-hip ratio (WHR) and breast size. Birth weight and birth length were obtained from medical records and ponderal index at birth was calculated. No relationship between birth parameters and facial or body femininity in women of reproductive age was found, also when controlled for adult sex steroid levels and BMI. Conclusions: The results suggest that, although previous research showed that birth parameters predict reproductive development and adult oestradiol level, they do not explain the variance in morphological femininity in women of reproductive age, trait that is thought to be a cue of a woman's estradiol level and fertility in mating context.

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Section: Introductionmentioning

confidence: 99%

Birth size and morphological femininity in adult women

2020

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“…It appears that being active helps to control low birth weight [ 67 ] and reduces the risk of macrosomia by up to 30% [ 41 ]. Both birth weight extremes are negatively associated with the development of the infant in the short and long term [ 68 , 69 , 70 , 71 , 72 ]. Less than half of the NICU admissions (a proxy for newborn health) were found in the IG (n = 9) compared to the CG (n = 20), with percentages for the total group being 13% vs. 29% respectively.…”

Section: Discussionmentioning

confidence: 99%

A Virtual Exercise Program throughout Pregnancy during the COVID-19 Pandemic Modifies Maternal Weight Gain, Smoking Habits and Birth Weight—Randomized Clinical Trial

Silva-José

Sánchez-Polán

Barakat

et al. 2022

JCM

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The intrauterine environment is key to health from a short- and long-term perspective. Birth weight is an important indicator that may influence the fetal environment due to epigenetics. Considering physical inactivity, in parallel with higher levels of stress, affecting smoking patterns and the physical and emotional health of the pregnant population, maintaining the health of future generations is crucial. A randomized clinical trial (NCT04563065) was conducted. One-hundred and ninety-two healthy pregnant individuals were assigned to the intervention (IG) or control (CG) group. Overall, significant differences were found between groups when stratified by birth weight (χ2 (1) = 6.610; p = 0.037) with low birth weight and macrosomia found more often in the CG (4% vs. 14% and 3% vs. 9%, respectively) and higher admissions to the neonatal intensive care unit (χ2 (1) = 5.075; p = 0.024) in the CG (20/28.6%) compared to the IG (9/13.0). Smoking during pregnancy was also found more often in the CG (12/17.1%) compared to the IG (3/4.4%) (p = 0.016). A virtual program of supervised exercise throughout pregnancy during the ongoing pandemic could help to maintain adequate birth weights, modify maternal smoking habits, and lower admissions to the neonatal intensive care unit.

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“…A meta-analysis on the association of BW and cancer mortality by Risnes et al [ 44 ] showed that BW in men was positively associated with cancer mortality, whereas in women there was no strong evidence. Later, a meta-analysis by Sharma et al [ 52 ] found conflicting results, with BW associated with the poorer prognosis of some cancers (prostate) but not others (breast). However, this aspect was not investigated in our study.…”

Section: Discussionmentioning

confidence: 99%

The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy

Tussardi

Tfaily

Locatelli

et al. 2022

IJERPH

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Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW,) however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene–Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and sex, age and smoking status were adjusted for. Of the 2287 participants reporting BW, 6.4% (n = 147) had low BW (<2500 g), and this proportion was greater in women than men (7.8% vs. 5.1%; p = 0.006). Both men and women with low BW were shorter than those with normal BW (mean ± SD: 160.2 ± 5.5 vs. 162.6 ± 6.5 cm in women, p = 0.009; 172.4 ± 6.1 vs. 174.8 ± 7.2 cm in men, p < 0.001). Although FEV1 and FVC were reduced in individuals with low BW, this was explained by associations with sex and height. In multivariable analysis, BW was not associated with respiratory diseases in adulthood. However, those with low BW had a higher risk of self-reported hospitalisation for lung disease before the age of two (10.3% vs. 4.1%; p < 0.001), severe respiratory infection before the age of five (16.9% vs. 8.8%; p = 0.001) and hypertension in adulthood (29.9% vs. 23.7%; p = 0.001); however, they had a lower risk of arrhythmia (2.7% vs. 5.8%; p = 0.027).

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Birth size and cancer prognosis: a systematic review and meta-analysis

Cited by 8 publications

References 24 publications

Birth size and morphological femininity in adult women

Birth size and morphological femininity in adult women

A Virtual Exercise Program throughout Pregnancy during the COVID-19 Pandemic Modifies Maternal Weight Gain, Smoking Habits and Birth Weight—Randomized Clinical Trial

The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases: Results from a Multi-Centre, Multi-Case Control Study in Italy

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