Birth weight and childhood obesity: a 12-country study

Qiao, Yijuan; Ma, Jingmei; Wang, Yi-Fan; Li, W; Katzmarzyk, Peter T.; Chaput, J-P; Fogelholm, Mikael; Johnson, William D.; Kuriyan, Rebecca; Kurpad, Anura; Lambert, Estelle V.; Maher, Carol; Maia, José; Matsudo, Victor Keihan Rodrigues; Olds, Tim; Onywera, Vincent; Sarmiento, Olga L.; Standage, Martyn; Tremblay, Mark S.; Tudor‐Locke, Catrine; Church, Timothy S.; Zhao, Pei; Hu, Gang

doi:10.1038/ijosup.2015.23

Cited by 146 publications

(100 citation statements)

References 33 publications

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“…In the context of the early programming hypothesis, some (pre-)pregnancy and perinatal factors have been repeatedly shown to correlate with offspring obesity. Macrosomia and large birth weight [6,7] as well as small size for gestational age [6,8,9] are associated with increased childhood adiposity and later onset of metabolic diseases. Among the maternal factors, the most noticeable characteristics are an elevated pBMI [10] , gestational diabetes mellitus (GDM) [3,11,12] , and preeclampsia [13] .…”

Section: Pregnancymentioning

confidence: 99%

Early Programming of Obesity Throughout the Life Course: A Metabolomics Perspective

et al. 2017

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Background: Over the last decades, research on early life risk factors for obesity and its comorbidities in early life has gained attention within the field of developmental origins of health and diseases. Metabolomics studies that are trying to find early life biomarker and intervention targets for the early development of obesity and associated cardiovascular diseases could help break the inter-generational cycle of obesity. Summary: Metabolomics studies in the field of early programming are scarce and causality is lacking at this stage, as most of the studies are cross-sectional. The main metabolites in the focus of obesity are branched-chain and aromatic amino acids, long-chain polyunsaturated fatty acids, lysophosphatidylcholines, and sphingomyelins. Sex and puberty have not been considered in most of the biomarker studies, but show differences in the metabolite associations to obesity. Key Messages: There is still a lot unknown about the associations between early programming exposures, metabolite concentrations, and the development of obesity. The few studies focusing on this topic find similar metabolite classes in the same age groups being associated with rapid early growth or obesity; but due to differences in the methodological and statistical approaches, the single species often differ. Therefore, more research, preferably with standardized approaches, is needed.

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Section: Pregnancymentioning

confidence: 99%

Early Programming of Obesity Throughout the Life Course: A Metabolomics Perspective

et al. 2017

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“…Una tendencia similar se mostró en el International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE), que incluye 12 países de ingresos altos, medios y bajos (PN 3.500-3.999 g, OR 1,45; IC 95%: 1,10-1,92; > 4.000 g, OR 2,08, IC 95%: 1,47-2,93, comparado con el grupo de referencia: 2.500-2.999 g) (36). El estudio internacional también mostró una asociación positiva entre el peso al nacer y el puntaje Z de IMC (36).…”

Section: Discussionunclassified

“…El estudio internacional también mostró una asociación positiva entre el peso al nacer y el puntaje Z de IMC (36). Nuestros resultados concuerdan con los resultados de los estudios descritos, aunque el incremento de riesgo de exceso de peso en nuestra muestra es más evidente en niños que tuvieron peso al nacer > 4.000 g a 4.500 g (OR 2,03, IC 95%: 1,14-3,60).…”

Section: Discussionunclassified

Asociación entre peso al nacer y factores de riesgo cardiometabólicos en niños de Bucaramanga, Colombia

2017

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Introducción: El peso a nacer puede ser un factor de riesgo a mediano plazo en el desarrollo de sobrepeso y obesidad, y a largo plazo como determinante de enfermedades cardiovasculares. Objetivo: Evaluar la asociación entre peso al nacer y factores de riesgo cardiometabólicos en niños de Bucaramanga, Colombia. Métodos: Estudio de corte transversal analítico en niños de 5 a 11 años (n=1282). Variables dependientes: hipertensión arterial, pre-hipertensión arterial, sobrepeso/obesidad, glucosa alterada, resistencia a la insulina, dislipidemia. Principal variable independiente: peso al nacer (g). Se emplearon modelos de regresión logística y lineal múltiple. Los datos fueron analizados en el programa estadístico Stata 12.0. Resultados: La prevalencia de exceso de peso (sobrepeso u obesidad) fue 22.93% IC 95% 20.64% a 25.33%, mientras la de bajo peso al nacer fue 3.70% IC 95% 2.65% a 5.00%. De los factores de riesgo el más prevalente fue exceso de peso seguido por colesterol LDL elevado (17.24% IC 95% 15.20% a 19.41%). El exceso de peso, el puntaje Z del IMC para la Edad y la presión arterial sistólica se asociaron de manera significativa con peso al nacer (OR: 1.44; IC 95% 1.10 a 1.89, p=0.006; β=0.23, IC 95%: 0.10 a 0.36, p=0.001 y β=1.18, IC 95%: 0.24 a 2.12, p=0.013, respectivamente), después de ajustar por edad, sexo, nivel socio económico, actividad física y antecedentes gineco-obstétricos maternos. Conclusiones: Los niños con mayor peso al nacer presentaron mayor probabilidad de desarrollar sobrepeso u obesidad y mayores niveles de presión arterial sistólica durante la etapa de su niñez.

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“…Another multinational, cross-sectional study of 5141 children aged 9-11 years was conducted in 12 countries by Qiao et al, showed that the multivariable-adjusted odds ratios (ORs) of childhood obesity were significantly higher among children whose birth weights were 3500-3999 g (OR 1.45; 95% confidence interval (CI): 1.10-1.92), and 4400 g (OR 2.08; 95% CI: 1.47-2.93), compared with the reference group (2500-2999 g). 14 The positive association between birth weight and the odds of childhood obesity was seen in girls, whereas a U-shaped association appeared in boys.…”

Section: Discussionmentioning

confidence: 99%

“…Studies conducted by Oldroyd et al, Li et al and Qiao et al were in concordance with our study findings. [13][14][15] Another study conducted by Hirschler et al concluded that low birth weight is not associated with overweight/obesity in children, but high birth weight was associated with overweight/ obesity and metabolic syndrome. …”

Section: Discussionmentioning

confidence: 99%

Association of birth weight with body mass index of school children of central India: a cross sectional study

Petkar

Thakre

Thakre³

et al. 2017

Int J Community Med Public Health

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Background: Overweight and obesity has become an important public health problem in both developed and developing nations. This is even more alarming as obese children are likely to become obese adults. Methods: A cross sectional study was conducted in a government aided school in urban area of Nagpur, Maharashtra during January 2016 to April 2016. This study was conducted in students of age group of 9 to 15 years to assess the association of birth weight and body mass index of school children. Height and weight of the children were measured according to standard guidelines. BMI was calculated and classified using the percentile charts according to age and gender. Data was collected using EPI Info version 7.2. Descriptive statistics using frequencies and percentages were used. Chi square test was used to indicate the differences between two proportions. Odds ratio was used to define the strength of the association. Results: The mean age of children was 11.92±1.27 and 11.31±1.27 in males and females respectively. In our study, there was a significant positive association between the birth weight and body mass index of the children. Conclusions: We found that the children whose birth weight was lower than 2500 grams were having decreased risk of being overweight/ obese in their later life with an odds ratio of 0.55 (0.34 to 0.90). But, the correlation between the birth weight and body mass index is weakly positive (r=0.063).

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Birth weight and childhood obesity: a 12-country study

Cited by 146 publications

References 33 publications

Early Programming of Obesity Throughout the Life Course: A Metabolomics Perspective

Early Programming of Obesity Throughout the Life Course: A Metabolomics Perspective

Asociación entre peso al nacer y factores de riesgo cardiometabólicos en niños de Bucaramanga, Colombia

Association of birth weight with body mass index of school children of central India: a cross sectional study

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