Birth‐weight differences at term are explained by placental dysfunction and not by maternal ethnicity

Morales‐Roselló, José; Dias, T.; Khalil, Asma; Fornés-Ferrer, Victoria; Ciammella, R.; Gimenez-Roca, L.; Perales‐Marín, Alfredo; Thilaganathan, B.

doi:10.1002/uog.19025

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…As we earlier suggested, the existence of low CPR values, would reflect a higher degree of growth restriction, regardless of BW centile ( Morales-Roselló et al., 2014 ; Morales-Roselló and Khalil, 2015 ). This was earlier observed in fetuses born in the Indian subcontinent ( Morales-Roselló et al., 2018 ), but this trend to growth restriction might be also carried by emigrants to the new place of residence ( Morales-Roselló et al., 2022 ) and according to our results would be only modified by the maternal BMI. This is also in line with investigations in emigrants suggesting that most of the BW variation is produced at the maternal and fetal level and very few (3%) at the place of residence level ( Mulinari et al., 2015 ).…”

Section: Discussionsupporting

confidence: 78%

Does emigration by itself improve birth weight? Study in European newborns of Indo-Pakistan origin

Roselló

Buongiorno

Loscalzo

et al. 2023

Journal of Migration and Health

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Section: Discussionsupporting

confidence: 78%

Does emigration by itself improve birth weight? Study in European newborns of Indo-Pakistan origin

Roselló

Buongiorno

Loscalzo

et al. 2023

Journal of Migration and Health

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“…Placental hypoplasia, indicated by low placental weight, has been associated with maternal cardiovascular disease, vasculitis, hypertension, diabetes mellitus, accelerated placental maturation, many of the major autosomal disorders, babies with trisomy, and major fetal malformations. 10,11,18,[21][22][23][24] Even though placental weight is an indicator of placental growth, it does not indicate the efficiency of the placental function. Most pathologists opine that the function and efficiency of the placenta are more important for fetal growth than measurements of weight alone: it indirectly depends on maternal well-being, including the nutritional state measured by maternal BMI.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Placental weight and its relationship with the birth weight of term infants and body mass index of the mothers

et al. 2023

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Objective Placental pathology is a well-known cause of perinatal and neonatal mortality and morbidity, and may correlate with placental growth, which can be assessed indirectly by anthropometric placental measurements. The aim of this cross-sectional study was to investigate mean placental weight and its relationship with birthweight and maternal body mass index (BMI). Methods Fresh (not formalin fixed) consecutively delivered placentae of term newborns (37–42 weeks), collected between February 2022 and August 2022, and the mothers and newborns, were included. Mean placental weight, birthweight and maternal BMI were calculated. Pearson’s correlation coefficient, linear regression, and one-way analysis of variance were used to analyse continuous and categorical data. Results Out of 390 samples, 211 placentae (with 211 newborns and mothers) were included in this study after exclusion criteria were applied. Mean placental weight was 494.45 ± 110.39 g, and mean term birth weight/placental weight ratio was 6.21 ± 1.21 (range, 3.35–11.62 g). Placental weight was positively correlated with birthweight and maternal BMI, but not with newborn sex. Linear regression effect estimation of placental weight on birthweight revealed a medium correlation ( R2 = 0.212; formula, 1.4553 × X + 2246.7, where X is placental weight [g]). Conclusion Placental weight was revealed to positively correlate with birthweight and maternal BMI.

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“…For example, customization 'normalises' smaller fetuses in Asian and Afro-Caribbean women, when women from these ethnicities are also at increased risk of stillbirth [34]. Similarly, other variable used in customised fetal growth charts such as maternal age, weight and parity have also been shown to be related to risk of stillbirth [35,36]. Apart from the concern that customisation of fetal growth is 'normalising' for variables that predispose to pregnancy pathology, there is also the question of biological rationale for customisation.…”

Section: Customized Chartsmentioning

confidence: 99%

Preventing term stillbirth: benefits and limitations of using fetal growth reference charts

Halimeh

Melchiorre

Thilaganathan

2019

Current Opinion in Obstetrics &Amp; Gynecology

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This review examines the variation in clinical practice with regards to ultrasound estimation of fetal weight, as well as calculation of fetal weight centiles from population/customised fetal growth references or fetal growth standards. Recent findingsPlacental dysfunction is associated with fetal smallness from intrauterine malnutrition as well as fetal disability and even stillbirth from hypoxemia. Although estimating fetal weight can be done accurately, the issue of which fetal weight centile chart should be used continues to be a contentious topic. The arguments against local fetal growth charts based on national borders and customization for variables known to be associated with pathology are substantial. As for other human diseases such as hypertension and diabetes, there is a rationale for the use of an international fetal growth reference standard. Irrespective of the choice of fetal growth reference standard, a significant limitation of national SGA detection programs to prevent stillbirth is that the majority of stillborn infants at term were not SGA at the time of demise.

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Birth‐weight differences at term are explained by placental dysfunction and not by maternal ethnicity

Abstract: Fetal BW variation at term is less dependent on ethnic origin and better explained by placental dysfunction. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

Cited by 9 publications

References 39 publications

Does emigration by itself improve birth weight? Study in European newborns of Indo-Pakistan origin

Does emigration by itself improve birth weight? Study in European newborns of Indo-Pakistan origin

Placental weight and its relationship with the birth weight of term infants and body mass index of the mothers

Preventing term stillbirth: benefits and limitations of using fetal growth reference charts

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