Birth weight is associated with inner cell mass grade of blastocysts

Licciardi, F.; McCaffrey, C.; Oh, Cheongeun; Schmidt-Sarosi, Cecilia; McCulloh, David H.

doi:10.1016/j.fertnstert.2014.10.039

Cited by 34 publications

(22 citation statements)

References 37 publications

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“…In this connection, a previous study that examined 224 ART cases who were undergoing a single fresh blastocyst transfer reported that the blastocysts with a more advanced inner cell mass (ICM) went on to become heavier babies, compared with those with a less advanced ICM. In contrast, the trophectoderm grade was not related to the birthweight . In this study, when the ICM grade of the blastocysts was divided into “A” and “non‐A,” the percentage of grade non‐A was 62.0% for the HRT group and 73.6% for the ovulatory group.…”

Section: Discussionmentioning

confidence: 56%

“…In contrast, the trophectoderm grade was not related to the birthweight. 22 In this study, when the ICM grade of the blastocysts was divided into "A" and "non-A," the percentage of grade non-A was 62.0% for the HRT group and 73.6% for the ovulatory group.…”

Section: Discussionmentioning

confidence: 82%

“…The key question is how the grade of ICM is related to the birthweight. The cited study found a relationship between the ICM grade and the birthweight when a single fresh embryo was transferred . But, this was not the case with frozen‐thawed blastocysts, possibly because of the low number of cases.…”

Section: Discussionmentioning

confidence: 99%

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Identifying a possible factor for the increased newborn size in singleton pregnancies after assisted reproductive technology using cryopreserved embryos, in comparison with fresh embryos

Ishii¹,

Shoda²,

Kubo³

et al. 2018

Reprod Medicine & Biology

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PurposeTo determine whether the cycle regimens that are used for endometrial preparation are associated with the birthweight (BW) after assisted reproductive technology (ART) using frozen‐thawed embryo transfer (FET).MethodsThe BW of singletons who were born by ART using FET was compared retrospectively, according to whether a FET was conducted in a hormone replacement therapy cycle (HRT, n = 403) or an ovulatory cycle (OVL, n = 117). The BW after timed intercourse (NAT, n = 162) also was investigated.ResultsThere were no significant differences in the age of the mothers, percentage of primiparas, gestational periods, Body Mass Index, and sex ratio between the HRT and OVL cycles. The average BW from HRT was significantly greater than that of OVL. The BW from HRT was also greater, compared with NAT, while statistical significance was not achieved between OVL and NAT. The putative factors affecting the BW, such as ovarian stimulation protocols, endometrial thickness, and the stage and quality of embryos, could not explain the difference in the BW between the HRT and OVL cycles.ConclusionAn increased BW from ART using FET seems to be ascribable to conditions of the endometrium, but not cryopreservation procedures per se, which might provide a mechanistic framework for understanding heavier neonates who are born by FET.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Identifying a possible factor for the increased newborn size in singleton pregnancies after assisted reproductive technology using cryopreserved embryos, in comparison with fresh embryos

Ishii¹,

Shoda²,

Kubo³

et al. 2018

Reprod Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…The degree of blastocoel expansion may be an essential factor in a successful pregnancy and should be prioritized when selecting a frozen blastocyst for transfer [35]. Some previous studies have emphasized the importance of the inner cell mass with respect to pregnancy establishment [36,37]. Irani et al applied the same embryo-grading criteria used in the analysis to 477 preimplantation-genetic-testing-confirmed singleeuploid blastocyst FET cycles.…”

Section: Discussionmentioning

confidence: 99%

Does the sex ratio of singleton births after frozen single blastocyst transfer differ in relation to blastocyst development?

Lou

Zhang

et al. 2020

Reprod Biol Endocrinol

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Purpose: To investigate the associations between blastocyst development and the sex ratio (male:female) among singleton live births resulting from single-blastocyst frozen embryo transfer (FET) cycles. Methods: Patients with singleton live births following the first autologous single FET of non-preimplantation genetic testing (PGT) blastocysts in a single reproductive medicine department between January 2015 and February 2019 were included in this retrospective study. The primary outcome measure was the singleton sex ratio. Multivariable logistic regression models were used to estimate the associations between blastocyst quality and singleton sex ratio after adjustment for some potential confounders. Results: There were 638 high-quality and 572 poor-quality single blastocyst FETs, and the blastocysts were conceived via 855 IVF and 355 ICSI treatments. A total of 1210 singleton live births were assessed. High-quality single blastocyst FET resulted in a significantly higher sex ratio than did poor-quality single blastocyst FET (60% vs. 49.7%, P < 0.001). The infertility cause was not associated with sex ratio among singleton live births (P = 0.537). The results of a multivariate analysis revealed that a high-quality blastocyst has a 150% higher probability of being male than a poor-quality blastocyst (adjusted odds ratio (aOR) 1.57; 95% CI 1.24-2, P < 0.001). Among the three blastocyst morphological parameters, Grade B trophectoderm was significantly associated with a higher sex ratio than Grade C (aOR 1.71; 95% CI 1.33-2.21. P < 0.001). Neither expansion degree nor inner cell mass degree were significantly associated with the singleton sex ratio. Conclusions: A single high-quality blastocyst FET has a higher chance of resulting in a male infant than a female infant. The results demonstrate that grade B trophectoderm confers benefits in improving the implantation potential of male blastocysts.

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“…Some previous studies have emphasized the importance of the inner cell mass with respect to the establishment of a pregnancy [35,36] . Irani et al applied the same embryo grading criteria used in analysis to 477 preimplantation genetic testing confirmed single-euploid blastocyst FET cycles.…”

Section: Mohamad Et Al Reported a Greater Likelihood Of Euploidy Amomentioning

confidence: 99%

Does the sex ratio of singleton births after frozen single blastocyst transfer differ according to blastocyst morphology?

Lou

Zhang

et al. 2020

Preprint

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Purpose: To investigate the associations between morphological blastocyst parameters and the sex ratio (male:female) of singleton live births resulting from single-blastocyst frozen embryo transfer (FET) cycles. Methods: This retrospective analysis included 1210 couples who underwent single-blastocyst FET of warmed day 5 or 6 blastocysts and achieved a singleton live birth between January 2015 and February 2019. The sex ratios in the different blastocyst groups were compared using the chi-square test. The associations of morphological blastocyst parameters, including the blastocoel expansion, inner cell mass and trophectoderm grades, with the sex ratios of live births were analyzed using multiple regression models. Results: The included female patients had an average age and body mass index of 30.5±4.5 years and 23.6±3.2 kg/m2, respectively. blastocyst transfers occurred on day 5 in 783 cases (64.7%) and day 6 in 427 cases (35.3%). Among the day 5 FET cycles, 55.4% of resulting infants were male and 44.6% were female, while among the day 6 cycles, 54.6% of infants were male and 45.4% were female ( P =0.074). Blastocysts quality was assessed according to morphological parameters, which was divided into high-quality (AA,AB,BB,BC) and poor-quality(AC,BC). High-quality blastocyst transfer was associated with a significantly higher sex ratio (60%, 383/638) relative to poor-quality transfer (49.7%, 284/572) ( P< 0.001). The sex ratio of births resulting from blastocyst transfer differed significantly with respect to the trophectoderm grade ( P <0.001). After adjusting for confounders, a grade B trophectoderm was significantly associated with a higher sex ratio among singleton live births (odds ratio: 0.591, 95% confidence interval: 0.463–0.756, P <0.001; reference: grade C trophectoderm). In contrast, the characteristics of blastocoel expansion and the score of the inner cell mass were not significantly associated with the sex ratio among singleton live births. Conclusions: The sex ratio among singleton live births is affected by the quality of blastocysts. A grade B trophectoderm is associated with a higher probability that a single-blastocyst FET cycle will result in a male infant.

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Birth weight is associated with inner cell mass grade of blastocysts

Cited by 34 publications

References 37 publications

Identifying a possible factor for the increased newborn size in singleton pregnancies after assisted reproductive technology using cryopreserved embryos, in comparison with fresh embryos

Identifying a possible factor for the increased newborn size in singleton pregnancies after assisted reproductive technology using cryopreserved embryos, in comparison with fresh embryos

Does the sex ratio of singleton births after frozen single blastocyst transfer differ in relation to blastocyst development?

Does the sex ratio of singleton births after frozen single blastocyst transfer differ according to blastocyst morphology?

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