1998
DOI: 10.1590/s1415-47571998000100026
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Birth weight of twins: 2. Fetal genetic effect on birth weight

Abstract: Intraclass correlation coefficients were calculated for the birth weights of twins born at three southeastern Brazilian hospitals, after adjustment of the natural logarithms of these weights for gestational age, its quadratic and cubic terms, sex, and their interactions. The data indicate that fetal genetic effect on birth weight might have the opportunity to be demonstrated by children born to undernourished women. Undernourishment, acting as a selective force, might enhance the existence of genotypes that de… Show more

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Cited by 5 publications
(6 citation statements)
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“…Analyzing the epidemiological factors, which were different in both populations, a higher proportion of adolescent mothers was observed at the HEG. Some studies showed a higher frequency of low birth weight among NB of teenage mothers (12)(13) , but previous studies carried pout in our institution did not find such associations (14)(15) .…”
Section: Discussioncontrasting
confidence: 66%
See 1 more Smart Citation
“…Analyzing the epidemiological factors, which were different in both populations, a higher proportion of adolescent mothers was observed at the HEG. Some studies showed a higher frequency of low birth weight among NB of teenage mothers (12)(13) , but previous studies carried pout in our institution did not find such associations (14)(15) .…”
Section: Discussioncontrasting
confidence: 66%
“…Fetuses with some degree of growth restriction will show more evidence of such malnutrition in the last weeks of pregnancy. Likewise, the genetic manifestations regarding growth are more evident as the GA increases (11)(12) . Such factors somehow explain the different growth curves for the populations of different ethnicities.…”
Section: Discussionmentioning
confidence: 99%
“…No que se refere aos aspectos biológicos, é fato que grande parte das crianças gêmeas apresenta intercorrências pré, peri e pós-natais. O desenvolvimento fetal de gêmeos ocorre num espaço menor devido à presença de mais um irmão no útero e vários estudos demonstram que eles podem nascer antes do que as crianças únicas, além de apresentarem baixo peso e estatura no nascimento (1) . Tais intercorrências são consideradas fatores de risco para possíveis alterações de linguagem (2,3) .…”
Section: Introductionunclassified
“…Contudo, é preciso que se tenha em mente que o crescimento intra-uterino deriva da somatória de fatores genéticos e ambientais, e que estes últimos poderão atuar de tal forma a mascarar o potencial genético de um determinado indivíduo 14 , Beiguelman e col. 15 , em 1998, comparando os dados de três hospitais de diferentes classes sociais, sugerem que o efeito genético fetal sobre o peso ao nascer teria maior oportunidade de se manifestar nas mães subnutridas, pois o coeficiente de herdabilidade estimado foi de 0,52 para o hospital de menor nível socioeconômico, enquanto os outros dois não mostraram efeito genético no peso ao nascer.…”
Section: Resultsunclassified