Objective
To investigate growth cessation at term and birth characteristic predictions in a large sample using Individualized Growth Assessment.
Methods
A prospective longitudinal study of 119 pregnancies with normal growth outcomes was carried out from 18 weeks, MA, to delivery. Measurements of head circumference (HC), abdominal circumference (AC), femur diaphysis length (FDL), mid-thigh circumference (ThC), head profile cube (Hcube), abdominal profile cube (Acube) and mid-arm circumference (ArmC) were obtained using 3D ultrasonography at 3–4 week intervals. Rossavik growth models were determined from these data using sample-specific and previously published procedures. These models were used to predict birth characteristics at different ages. Predicted and measured birth characteristics were compared and Percent Differences (% Diff) calculated. Growth cessation age [GCA] was defined by the absence of systematic change in % Diff values [derived from predictions at GCA’s] in those fetuses delivering after the GCA. Systematic (mean % Diff) and random (% Diff 95% range) prediction errors were compared to published data and when using different assumptions about growth cessation. New Growth Potential Realization Index [GPRI] reference ranges were established.
Results
Growth cessation ages were 38 weeks for HC, AC, THC, WT and ArmC [CHL: 38.5 weeks]. Assuming growth-to-delivery gave positive slopes [4/6 different from zero] and non-random distributions for % Differences after the 38 weeks. Systematic and random prediction errors, based on predictions at the GCA’s, were similar to those published previously except for WT [based on Hcube and Acube]. However, predicted weights derived from BPD, AC and TVol had prediction errors of −4.1+/−8.3%. After correction for non-zero systematic prediction errors [AC, ThC, ArmC, WT], mean GPRI values were close to 100, with normal ranges similar [WT larger] than those obtained previously.
Conclusions
Growth cessation at term occurred for all six birth characteristics studied. Prediction errors and GPRI normal ranges in this large sample were similar to those obtained previously in much smaller samples. A simple weight estimation procedure utilizing three anatomical parameters (BPD, AC, TVol) gave the most precise WT predictions. Our results provide the methods and standards required to individualize the assessment of neonatal growth outcome.