Birthweight by Gestational Age and Sex at a Rural Referral Center

Storms, Michelle R.; Howe, Robert S. Van

doi:10.1038/sj.jp.7211065

Cited by 20 publications

(16 citation statements)

References 26 publications

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“…Although likely to be less precise than maternal reports or measured birthweight, lower self-reported birthweight was associated with female sex, increased deprivation index, multiple births and self-reported maternal smoking. These associations were not only in the expected direction, but demonstrated effect sizes which have been demonstrated in other studies with more accurate birthweight data available 19 , 20 . This is in keeping with a recent study of 541 individuals where a positive correlation was observed between self-reported birthweight in the Million Women Study and their recorded birthweight in 1946, as part of the MRC National Survey of Health and Development birth cohort 21 …”

Section: Discussionsupporting

confidence: 89%

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study

Tyrrell

Yaghootkar

Freathy

et al. 2013

International Journal of Epidemiology

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Background The UK Biobank study provides a unique opportunity to study the causes and consequences of disease. We aimed to use the UK Biobank data to study the well-established, but poorly understood, association between low birthweight and type 2 diabetes.Methods We used logistic regression to calculate the odds ratio for participants’ risk of type 2 diabetes given a one standard deviation increase in birthweight. To test for an association between parental diabetes and birthweight, we performed linear regression of self-reported parental diabetes status against birthweight. We performed path and mediation analyses to test the hypothesis that birthweight partly mediates the association between parental diabetes and participant type 2 diabetes status.Results Of the UK Biobank participants, 277 261 reported their birthweight. Of 257 715 individuals of White ethnicity and singleton pregnancies, 6576 had type 2 diabetes, 19 478 reported maternal diabetes (but not paternal), 20 057 reported paternal diabetes (but not maternal) and 2754 participants reported both parents as having diabetes. Lower birthweight was associated with type 2 diabetes in the UK Biobank participants. A one kilogram increase in birthweight was associated with a lower risk of type 2 diabetes (odds ratio: 0.74; 95% CI: 0.71, 0.76; P = 2 × 10−57). Paternal diabetes was associated with lower birthweight (45 g lower; 95% CI: 36, 54; P = 2 × 10−23) relative to individuals with no parental diabetes. Maternal diabetes was associated with higher birthweight (59 g increase; 95% CI: 50, 68; P = 3 × 10−37). Participants’ lower birthweight was a mediator of the association between reported paternal diabetes and participants’ type 2 diabetes status, explaining 1.1% of the association, and participants’ higher birthweight was a mediator of the association between reported maternal diabetes and participants’ type 2 diabetes status, explaining 1.2% of the association.Conclusions Data from the UK Biobank provides the strongest evidence by far that paternal diabetes is associated with lower birthweight, whereas maternal diabetes is associated with increased birthweight. Our findings with paternal diabetes are consistent with a role for the same genetic factors influencing foetal growth and type 2 diabetes.

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Section: Discussionsupporting

confidence: 89%

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study

Tyrrell

Yaghootkar

Freathy

et al. 2013

International Journal of Epidemiology

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“…Infant size was bigger for the male term followed by female term, male preterm and female preterm. Many literature also found this kind of interaction effect on birth size [38].…”

Section: Discussionmentioning

confidence: 73%

Canonical Correlation Analysis of Infant's Size at Birth and Maternal Factors: A Study in Rural Northwest Bangladesh

et al. 2014

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This analysis was conducted to explore the association between 5 birth size measurements (weight, length and head, chest and mid-upper arm [MUAC] circumferences) as dependent variables and 10 maternal factors as independent variables using canonical correlation analysis (CCA). CCA considers simultaneously sets of dependent and independent variables and, thus, generates a substantially reduced type 1 error. Data were from women delivering a singleton live birth (n = 14506) while participating in a double-masked, cluster-randomized, placebo-controlled maternal vitamin A or β-carotene supplementation trial in rural Bangladesh. The first canonical correlation was 0.42 (P<0.001), demonstrating a moderate positive correlation mainly between the 5 birth size measurements and 5 maternal factors (preterm delivery, early pregnancy MUAC, infant sex, age and parity). A significant interaction between infant sex and preterm delivery on birth size was also revealed from the score plot. Thirteen percent of birth size variability was explained by the composite score of the maternal factors (Redundancy, RY/X = 0.131). Given an ability to accommodate numerous relationships and reduce complexities of multiple comparisons, CCA identified the 5 maternal variables able to predict birth size in this rural Bangladesh setting. CCA may offer an efficient, practical and inclusive approach to assessing the association between two sets of variables, addressing the innate complexity of interactions.

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“…The babies averaged 39.6 (SD = 1.1) weeks gestational age, birthweight of 3536 (SD = 460) grams, length of 49.9 (SD = 2.5) centimeters, and head circumference of 34.4 (SD = 1.7) centimeters. A review of 2098 infants born at our facility from 1999 through 2001 found that 95.19% were Caucasian, 2.43% Native American, 1.00% mixed race, 0.86% African American, 0.33% Hispanic, and 0.19% Asian American[11]. No shift in the racial/ethnic characteristics of this population has occurred in the intervening years.…”

Section: Resultsmentioning

confidence: 99%

Gastroesophageal reflux symptoms in infants in a rural population: longitudinal data over the first six months

Howe

Storms

2010

BMC Pediatr

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BackgroundIncreasing numbers of infants are receiving prescription medications for symptoms associated with gastroesophageal reflux. Our aim was to prospectively measure reported gastroesophageal reflux symptoms in healthy term infants for the first six months of life.MethodsIn a prospective cohort study in the rural Upper Peninsula of Michigan, 128 consecutive maternal-infant pairs were followed for six months and administered the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R) at the one-month, two-month, four-month, and six-month well-child visits.ResultsThe I-GERQ-R scores decreased with age. Average scores were 11.74 (SE = 5.97) at one-month, 9.97(4.92) at two-months, 8.44(4.39) at four-months, and 6.97(4.05) at six months. Symptoms associated with colic were greatest at one month of age.ConclusionSymptoms of gastroesophageal reflux as measured by the I-GERQ-R decrease with age in the first six months of life in otherwise healthy infants; however the I-GERQ-R may have difficulty differentiating gastroesophageal reflux disease from colic in those under 3 months of age.

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Birthweight by Gestational Age and Sex at a Rural Referral Center

Cited by 20 publications

References 26 publications

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study

Canonical Correlation Analysis of Infant's Size at Birth and Maternal Factors: A Study in Rural Northwest Bangladesh

Gastroesophageal reflux symptoms in infants in a rural population: longitudinal data over the first six months

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