Bis-(2-propylheptyl)phthalate (DPHP) metabolites emerging in 24h urine samples from the German Environmental Specimen Bank (1999–2012)

Schütze, André; Gries, Wolfgang; Kolossa-Gehring, Marike; Apel, Petra; Schröter-Kermani, Christa; Fiddicke, Ulrike; Leng, G.; Brüning, Thomas; Koch, Holger M.

doi:10.1016/j.ijheh.2015.05.007

Cited by 55 publications

(24 citation statements)

References 21 publications

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“…Time trend studies have been used to detect decreasing trends of DEHP metabolites and other "old" phthalates in urine from German men [190], Swedish men [191], Swedish women [192] and the US population [193]. At the same time, increasing time trends have been found for the still widely used phthalates DiDP and DPHP [192,193,194]. The time trend for DiNP has been reported to be increasing in Swedish adults [191] and in the US population [193], but decreasing in German men [190].…”

Section: Time Trends Of Urinary Metabolitesmentioning

confidence: 99%

Brominated Flame Retardants and Organophosphate Esters in Preschool Dust and Children’s Hand Wipes

Larsson

Wit

Sellström

et al. 2018

Environ. Sci. Technol.

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Children spend a considerable part of their day in preschool, where they may be exposed to hazardous chemicals in indoor dust. In this study, brominated flame retardants (BFRs) and organophosphate esters (OPEs) were analyzed in preschool dust ( n = 100) and children's hand wipe samples ( n = 100), and diphenyl phosphate (DPHP) was analyzed in urine ( n = 113). Here we assessed children's exposure via dust, identified predictors for chemicals in dust, and studied correlations between different exposure measures. The most abundant BFRs in dust were decabromodiphenyl ether (BDE-209) and decabromodiphenyl ethane (DBDPE) found at median levels of 270 and 110 ng/g dust, respectively. Tris(2-butoxyethyl) phosphate (TBOEP) was the most abundant OPE, found at a median level of 79 000 ng/g dust. For all OPEs and some BFRs, there were significant correlations between the levels in dust and hand wipes. In addition, triphenyl phosphate (TPHP) in preschool dust was significantly correlated with the corresponding metabolite DPHP in children's urine. The levels of pentaBDEs in dust were higher in older preschools compared with newer, whereas levels of DBDPE were higher in newer preschools. Children's estimated intakes of individual BFRs and OPEs via preschool dust were below available health-based reference values. However, there are uncertainties about the potential health effects of some emerging BFRs and OPEs.

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Section: Time Trends Of Urinary Metabolitesmentioning

confidence: 99%

Brominated Flame Retardants and Organophosphate Esters in Preschool Dust and Children’s Hand Wipes

Larsson

Wit

Sellström

et al. 2018

Environ. Sci. Technol.

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“…The main tasks of the German ESB are not only monitoring and documenting, but also assessing the changes in the chemical burden of humans and the environment over time. Thus, a retrospective an sensitive analysis of the full set of parabens (including the iso-forms) in these 24 h urine samples is possible and allows for the assessment of both past and current exposures including the investigation of exposure time trends, as has been done previously with phthalates (Wittassek et al, 2007;Göen et al, 2011;Schütze et al, 2015), DINCH (Schütze et al, 2014) and bisphenol A (Koch et al, 2012).…”

Section: G Modelmentioning

confidence: 99%

Parabens in 24h urine samples of the German Environmental Specimen Bank from 1995 to 2012

Moos

Koch

Angerer

et al. 2015

International Journal of Hygiene and Environmental Health

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“…No occupational DPHP exposure data have been published earlier [1]. Gries, Schütze, and co-workers [14,15] have reported OH-MPHP urinary concentrations below 1 µg/L for the general population. This is in line with the data of our previous study: The urinary concentrations of the occupationally non-exposed population were below 1 µg/L [9].…”

Section: Cable Factorymentioning

confidence: 99%

Occupational Exposure of Plastics Workers to Diisononyl Phthalate (DiNP) and Di(2-propylheptyl) Phthalate (DPHP) in Finland

Porras

Hartonen

Koponen

et al. 2020

IJERPH

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The aim of this study was to assess occupational exposure to diisononyl phthalate (DiNP) and di(2-propylheptyl) phthalate (DPHP] in Finland. Four companies took part in the research project: A cable factory, a plastic producing company, a producer of coated textiles, and a tarpaulin producer. The cable factory used DPHP (and occasionally also diisodecyl phthalate, DiDP), the plastic producing company used both DPHP and DiNP, and the latter two companies used DiNP in their production. Exposure was assessed by measuring phthalate metabolites in urine samples (biomonitoring) and by performing air measurements. Low-level occupational exposure to DiNP was observed in the company that produced coated textiles-out of eight workers, one extruder operator was exposed to DiNP at levels exceeding the non-occupationally exposed population background levels. Some workers in the cable factory and the plastics producing company were occupationally exposed to DPHP. Air levels of phthalates were generally low, mostly below the limit of quantification. All phthalate metabolite concentrations were, however, well below the calculated biomonitoring equivalents, which suggests that the health risks related to the exposure are low.

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Bis-(2-propylheptyl)phthalate (DPHP) metabolites emerging in 24h urine samples from the German Environmental Specimen Bank (1999–2012)

Cited by 55 publications

References 21 publications

Brominated Flame Retardants and Organophosphate Esters in Preschool Dust and Children’s Hand Wipes

Brominated Flame Retardants and Organophosphate Esters in Preschool Dust and Children’s Hand Wipes

Parabens in 24h urine samples of the German Environmental Specimen Bank from 1995 to 2012

Occupational Exposure of Plastics Workers to Diisononyl Phthalate (DiNP) and Di(2-propylheptyl) Phthalate (DPHP) in Finland

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