Bis(3-butylamino-4-nitro)piperazine

Abstract

2,4-Difluoronitrobenzene is treated sequentially with butylamine and then piperazine to prepare a building block for forming a crystalline lattice by non-covalent interactions. A single crystal X-ray structure determination was performed.

Reactions of 4,5-difluoro-1,2-dinitrobenzene with amines in dimethylformamide or EtOH

“…A literature survey of some reactions of fluorinated and nitrated aromatic compounds with amines. 1–11 …”

“…Dimer 4, with a flexible spacer, crystallised with open framework channels of 10 Å in diameter, 4 whereas dimer 5, with a more rigid spacer, was close packed. 5 The reaction of N-methyl-o-phenylenediamine 6 with 4,5-difluoro-1,2-dinitrobenzene 7 was studied as a potential iterative approach to 1,4-dihydro-N-heteroacenes, which may have interesting electronic properties. 6,7 The reaction of 2-fluoronitrobenzene 9 with enaminones gave aposafranones and their N-oxides, with butylamine and other amines gave 2-aminobenzimidazoles, with butylamine and other amines gave isoalloxazines and with aminomethylpyrazoles gave more complex medicinally active heterocycles [8][9][10][11] (Scheme 2).…”

“…A literature survey of some reactions of fluorinated and nitrated aromatic compounds with amines. [1][2][3][4][5][6][7][8][9][10][11] Scheme 2. Some commercially available nitrated fluorobenzenes.…”