Bis(alkynyl) PTA and DAPTA complexes of Pt(II) and Pd(II)

Braddock‐Wilking, Janet; Acharya, Sitaram; Rath, Nigam P.

doi:10.1016/j.poly.2014.11.003

Cited by 8 publications

(6 citation statements)

References 61 publications

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“…The situation, in fact, is complicated by the possible presence of different conformers due to the syn or anti orientations that can take the acyl groups in the DAPTA ligands. This phenomenon, which had been previously reported for palladium and platinum complexes coordinating two DAPTA molecules, [57][58][59] is highlighted by the presence in the NMR spectra of sets of signals attributable to more species. For instance, 31 Only in the case of the less encumbered complex 2 a, a fast interconversion of isomers at room temperature can be observed.…”

Section: Synthesis Of Pta/dapta Palladium(ii) Imidoyl Complexessupporting

confidence: 69%

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Palladium(II)‐Imidoyl Complexes: A New Piece in the Puzzle of Organopalladium Anticancer Agents

Bortolamiol,

Novaselich,

Tupini

et al. 2024

Eur J Inorg Chem

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Oursearch of new organopalladium compounds able to promote an effective antiproliferative action towards ovarian cancer cells continues. In this paper we have examined for the first time the anticancer activity of palladium imidoyl complexes, for which two different types of phosphines have been chosen as ancillary ligands: i) PTA and DAPTA to take advantage from their solubility in aqueous environment, and ii) dppf for combining the action of the Pd‐imidoyl fragment with that, well‐known, of ferrocene. The synthetic protocols as well as the exhaustive characterisation of the complexes through spectroscopic and diffractometric methods are described. In vitro tests carried out to assess the cytotoxicity of the new compounds towards two ovarian cancer cell lines (one cisplatin sensitive and the other cisplatin resistant) have revealed an interesting effect of the halide coordinated to the palladium centre (halogen effect). Moreover, all complexes have shown the same activity against the cisplatin‐sensitive (A2780) and cisplatin‐resistant (A2780cis) cell lines, suggesting different modes of action with respect to the “classical” platinum‐based drugs. Finally, a selection of the most active compounds has shown some selectivity towards ovarian cancer cells.

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Section: Synthesis Of Pta/dapta Palladium(ii) Imidoyl Complexessupporting

confidence: 69%

“…Each compound's IC 50 value (the compound concentration inhibiting cell proliferation of 50 %) were determined. [57][58][59][60]…”

Section: Antiproliferative Activitymentioning

confidence: 99%

Palladium(II)‐Imidoyl Complexes: A New Piece in the Puzzle of Organopalladium Anticancer Agents

Bortolamiol,

Novaselich,

Tupini

et al. 2024

Eur J Inorg Chem

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“…There are a couple of reports on Pd(II) complexes with the emphasis more on structural studies rather than photophysical properties . For example, Braddock-Wilking reported some cis - and trans -Pd(II) and Pt(II) complexes bearing 1,3,5-triaza-7-phosphaadamantane and 3,7-diacetyl-1,3,7-triaza-5-phospha bicyclo [3.3.1]nonane 185 (Chart ) as auxiliaries . The impact of bulkier auxiliary was clearly observed in the geometry as well as in the bond angles in the molecular structure of complexes (Figure a).…”

Section: Structure–property Relationshipsmentioning

confidence: 98%

“…365 For example, Braddock-Wilking reported some cis-and trans-Pd (II) and Pt(II) complexes bearing 1,3,5-triaza-7-phosphaadamantane and 3,7-diacetyl-1,3,7-triaza-5-phospha bicyclo [3.3.1]nonane 185 (Chart 20) as auxiliaries. 371 The impact of bulkier auxiliary was clearly observed in the geometry as well as in the bond angles in the molecular structure of complexes (Figure 19a). For instance, whereas Pt(II) complex adopted square planar geometry, Pd(II) complex had slightly distorted square planar geometry.…”

Section: Chemical Reviewsmentioning

confidence: 99%

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Rise of Conjugated Poly-ynes and Poly(Metalla-ynes): From Design Through Synthesis to Structure–Property Relationships and Applications

et al. 2018

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Conjugated poly-ynes and poly(metalla-ynes) constitute an important class of new materials with potential application in various domains of science. The key factors responsible for the diverse usage of these materials is their intriguing and tunable chemical and photophysical properties. This review highlights fascinating advances made in the field of conjugated organic poly-ynes and poly(metalla-ynes) incorporating group 4-11 metals. This includes several important aspects of conjugated poly-ynes viz. synthetic protocols, bonding, electronic structure, nature of luminescence, structure-property relationships, diverse applications, and concluding remarks. Furthermore, we delineated the future directions and challenges in this particular area of research.

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Coordination chemistry of 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) and derivatives. Part III. Variations on a theme: Novel architectures, materials and applications

Guerriero

Peruzzini

Gonsalvi

2018

Coordination Chemistry Reviews

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Bis(alkynyl) PTA and DAPTA complexes of Pt(II) and Pd(II)

Cited by 8 publications

References 61 publications

Palladium(II)‐Imidoyl Complexes: A New Piece in the Puzzle of Organopalladium Anticancer Agents

Palladium(II)‐Imidoyl Complexes: A New Piece in the Puzzle of Organopalladium Anticancer Agents

Rise of Conjugated Poly-ynes and Poly(Metalla-ynes): From Design Through Synthesis to Structure–Property Relationships and Applications

Coordination chemistry of 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) and derivatives. Part III. Variations on a theme: Novel architectures, materials and applications

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