Bis-pyrene probes of foldamer conformation in solution and in phospholipid bilayers

Abstract

An optimized fluorescent probe, developed using spectroscopic and crystallographic analysis, reported on peptide foldamer conformation in different environments and revealed that phospholipid chirality can influence conformation.

A Pyrene‐based Probe for Antimony with Special Excimer Fluorescence

“…When the concentration of pyrene solution was high, the excited pyrene fluorogens will pack with each other and emit fluorescence at about 460 nm, which is referred to the pyrene excimers. Similar phenomenon can be observed when pyrene‐based compound is added in the mixture of its solvent and non‐solvent with suitable fraction, which can force the aggregation of compounds and give a hand to the formation of pyrene excimers , . The formation of pyrene excimers will be influenced by lots of factors, such as the concentration of pyrene molecules in the system, the interaction between the pyrene fluorogens, the steric configuration of the pyrene‐based molecules and so on , .…”

Synthetic Supramolecular Systems in Life-like Materials and Protocell Models

“…148 It is important to note the achiral structure of the transmembrane a-aminoisobutyric folded oligomer (foldamer), which allows a uniform induction of its helical configuration by the ''controller'' metal complex. 149 This structural change mimics that of G-protein-coupled receptors such that different ligands induce opposite agonist-antagonist responses with selective and competitive binding profiles. Beyond this peptide-based design, abiotic foldamers (i.e., not based on biological molecules) are currently under study as fully artificial mimics of biomacromolecules, displaying dynamic structures with secondary, tertiary, and quaternary protein foldings.…”

An All-Photonic Molecular Amplifier and Binary Flip-flop

“…A schematic example of this feedback concept is shown in Figure 1 for two dye functionalities substituted onto an E/Z photoswitch core 49 in which E → Z photoisomerization leads to red-shifted excimer emission. 50,51 The single emissive/responsive species discussed here is merely one approach towards all-photonic feedback: other approaches toward feedback might include switchable FRET or a photoacid paired with a pH-responsive fluorescent dye, with the single requirement that the emission spectrum of each state must be selectively matched to the absorption spectra of the other state.…”