Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

Nabuurs, Rob J.A.; Kapoerchan, Varsha V.; Metaxas, Athanasios; Hafith, Sarah; Backer, Maaike de; Welling, Mick M.; Jiskoot, Wim; Nieuwendijk, Adrianus M. C. H. van den; Windhorst, Albert D.; Overkleeft, Herman S.; Buchem, Mark A. van; Overhand, Mark; Weerd, Louise van der

doi:10.1016/j.bmc.2016.05.022

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…All reagents and solvents were commercially purchased and used as received without further purification. Ligand 2‐bpeb was synthesized according to the previous literature methods . Elemental analyses for C, H and N were performed on a PerkinElmer 240C Elemental Analyzer at the analysis centre of Nanjing University.…”

Section: Methodsmentioning

confidence: 99%

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr₂O₇²⁻ and MnO₄⁻

Zhang

Zhao

Chen

et al. 2019

Chemistry An Asian Journal

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Due to their striking opticalp roperties, luminescent coordination polymers as sensors for the detection of hazardous species have drawn interest of researchers in consideration of the control of environmental pollution. In this work, the organic ligand 2-(4-((E)-2-(pyridine-2-yl)vinyl)styryl)pyridine (2-bpeb),w hich possesses al arge p-conjugated system, was employedt or eact with d 10 metal ions to obtain novel luminescentc oordination polymers. Three complexes [Cd(2-bpeb) 0.5 (CNA)(H 2 O)] (CP1), [Cd(2-bpeb) 0.5 (NDC)] (CP2) and [Zn(2-bpeb)(BDC)] (CP3)w ere synthesized successfully by introducing carboxylic acids of 4-carboxycinnamic acid (H 2 CNA), 2,6-naphthalene dicarboxylica cid (H 2 NDC) and 1,4benzenedicarboxylica cid (H 2 BDC) as auxiliary ligands. Because of the existence of the large p-conjugated system and d 10 metal ions, all of these coordinationp olymers exhibit striking fluorescencep roperties.I mpressively,a ll of them can functiona ss ensors for the detection of highly oxidizing anionsM nO 4 À and Cr 2 O 7 2À ,w ith an increased sensitivity for MnO 4 À .Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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Section: Methodsmentioning

confidence: 99%

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr₂O₇²⁻ and MnO₄⁻

Zhang

Zhao

Chen

et al. 2019

Chemistry An Asian Journal

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“…Unfortunately, the safety and selectivity advantages of using NBS are counterbalanced by other issues. Specifically, light irradiation is often ineffective as an initiator for NBS [26,30], introducing the necessity to add a radical initiator, such as azobisisobutyronitrile (AIBN) [31][32][33][34] or benzoyl peroxide [35,36]; substances affected by safety concerns on transportation, storage, and use. Moreover, the regeneration of the halogen comes at a cost: the release of stoichiometric amounts of succinimide, whose recovery requires additional chemical operations, and reconversion to NBS is typically accomplished with stoichiometric Br 2 [37,38].…”

Section: Introductionmentioning

confidence: 99%

Light on the sustainable preparation of aryl-cored dibromides

Roncaglia,

Ughetti,

Porcelli

et al. 2024

Beilstein J. Org. Chem.

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Both aryl and benzyl polybromides have gained significant importance as reactive building blocks in polymer and materials chemistry. Their preparation primarily relies on established synthetic methods using molecular bromine or N-bromosuccinimide, known for their reliability and effectiveness. However, from a sustainability perspective, these methods suffer from the generation of stoichiometric amounts of byproducts and often encounter selectivity troubles. To mitigate these issues, we extended the greener peroxide-bromide halogenation method, initially developed for monobromides, to afford aryl-cored polybromides in high yields. The same method can be employed in two variants modulated by light irradiation. This external switch can be used to selectively trigger side-chain or core halogenation.

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Synthetic strategies of functionalized pyridines and their therapeutic potential as multifunctional anti-Alzheimer's agents

Shaik

Damu

Reddy

2023

Recent Developments in the Synthesis and Applications of Pyridines

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Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

Cited by 7 publications

References 27 publications

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr₂O₇²⁻ and MnO₄⁻

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr₂O₇²⁻ and MnO₄⁻

Light on the sustainable preparation of aryl-cored dibromides

Synthetic strategies of functionalized pyridines and their therapeutic potential as multifunctional anti-Alzheimer's agents

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Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

Cited by 7 publications

References 27 publications

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr2O72− and MnO4−

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr2O72− and MnO4−

Light on the sustainable preparation of aryl-cored dibromides

Synthetic strategies of functionalized pyridines and their therapeutic potential as multifunctional anti-Alzheimer's agents

Contact Info

Product

Resources

About

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr₂O₇²⁻ and MnO₄⁻

Water‐Stable Coordination Polymers as Dual Fluorescent Sensors for Highly Oxidizing Anions Cr₂O₇²⁻ and MnO₄⁻