Bisabolane sesquiterpenes and α-pyrone derivative from endophytic fungus Zopfiella sp

Sun, Li-Tang; Chen, Yao; Yang, Huixiang; Li, Zhenghui; Liu, Ji‐Kai; Wang, Guo-Kai; Feng, Tao

doi:10.1016/j.phytol.2020.03.008

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…led to the isolation of undescribed bisabolane sesquiterpenoids zopfiellin B ( 98 ) and C ( 99 ); the former is a rare trinor-bisabolane sesquiterpenoid, and the latter possesses an unusual aromatic core. These compounds displayed mild cytotoxicity against the A-549, MCF-7, and HeLa cell lines [ 67 ]. Aspergoterpenin A ( 100 ), isolated from Aspergillus versicolor , is the first example of a ketal-bridged-ring part in the degraded natural bisabolane-type sesquiterpene structure.…”

Section: Resultsmentioning

confidence: 99%

Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi

Ortega

Torres-Mendoza

et al. 2021

JoF

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Among microorganisms, endophytic fungi are the least studied, but they have attracted attention due to their high biological diversity and ability to produce novel and bioactive secondary metabolites to protect their host plant against biotic and abiotic stress. These compounds belong to different structural classes, such as alkaloids, peptides, terpenoids, polyketides, and steroids, which could present significant biological activities that are useful for pharmacological or medical applications. Recent reviews on endophytic fungi have mainly focused on the production of novel bioactive compounds. Here, we focus on compounds produced by endophytic fungi, reported with uncommon bioactive structures, establishing the neighbor net and diversity of endophytic fungi. The review includes compounds published from January 2015 to December 2020 that were catalogued as unprecedented, rare, uncommon, or possessing novel structural skeletons from more than 39 different genera, with Aspergillus and Penicillium being the most mentioned. They were reported as displaying cytotoxic, antitumor, antimicrobial, antiviral, or anti-inflammatory activity. The solid culture, using rice as a carbon source, was the most common medium utilized in the fermentation process when this type of compound was isolated.

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Section: Resultsmentioning

confidence: 99%

Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi

Ortega

Torres-Mendoza

et al. 2021

JoF

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“…In addition, Mortierella is often thought to promote plant growth and increase biomass (Li, S. J. et al, 2018 ; Ozimek and Hanaka, 2020 ; Zhang et al, 2020 ). For Zopfiella , Sun et al ( 2020 ) found that species from this genus are capable of producing sesquiterpenes and α-pyranone derivatives.…”

Section: Discussionmentioning

confidence: 99%

Colonization characteristics of fungi in Polygonum hydropipe L. and Polygonum lapathifolium L. and its effect on the content of active ingredients

Zhang

Lv²,

Tian³

et al. 2022

Front. Plant Sci.

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Polygonum hydropiper, is a plant of the Persicaria genus, which is commonly used to treat various diseases, including gastrointestinal disorders, neurological disorders, inflammation, and diarrhea. However, because of different local standards of P. hydropiper, people often confuse it with Polygonum lapathifolium L. and other closely related plants. This poses a serious threat to the safety and efficacy of the clinical use of P. hydropiper. This study aims to determine the six active ingredients of P. hydropiper and P. lapathifolium. Then the endophytic fungi and rhizosphere soil of the two species were sequenced by Illumina Miseq PE300. The results show significant differences between the community composition of the leaves, stems, and roots of the P. hydropiper and the P. lapathifolium in the same soil environment. Of the six secondary metabolites detected, five had significant differences between P. hydropiper and P. lapathifolium. Then, we evaluated the composition of the significantly different communities between P. hydropiper and P. lapathifolium. In the P. hydropiper, the relative abundance of differential communities in the leaves was highest, of which Cercospora dominated the differential communities in the leaves and stem; in the P. lapathifolium, the relative abundance of differential community in the stem was highest, and Cladosporium dominated the differential communities in the three compartments. By constructing the interaction network of P. hydropiper and P. lapathifolium and analyzing the network nodes, we found that the core community in P. hydropiper accounted for 87.59% of the total community, dominated by Cercospora; the core community of P. lapathifolium accounted for 19.81% of the total community, dominated by Sarocladium. Of these core communities, 23 were significantly associated with active ingredient content. Therefore, we believe that the community from Cercospora significantly interferes with recruiting fungal communities in P. hydropiper and affects the accumulation of secondary metabolites in the host plant. These results provide an essential foundation for the large-scale production of P. hydropiper. They indicate that by colonizing specific fungal communities, secondary metabolic characteristics of host plants can be helped to be shaped, which is an essential means for developing new medicinal plants.

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“…Previously, bisabolane sesquiterpenoids and α-pyrones were obtained and reported. 8 Currently, four 3-decalinoyltetramic acid derivatives, zofielliamides A–D (1–4, Fig. 1 ), were obtained in the study of the same extract.…”

Section: Introductionmentioning

confidence: 90%

“…could inhibit the growth of Pseudomonas syringae , a well-known pathogen that causes kiwi fruit canker disease. 8 In order to discover the antibacterial chemical constituent from this fungus, a chemical investigation on the extract of the fermentation in rice medium was carried out. Previously, bisabolane sesquiterpenoids and α-pyrones were obtained and reported.…”

Section: Introductionmentioning

confidence: 99%