Bisabolane sesquiterpenes from the leaves of Lindera benzoin reduce prostaglandin E2 formation in A549 cells

Ryen, Astrid Henz; Göls, Thomas; Steinmetz, Julia; Tahir, Ammar; Jakobsson, Per‐Johan; Backlund, Anders; Urban, Ernst; Glasl, Sabine

doi:10.1016/j.phytol.2020.04.015

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…The relative low requirements for manual handling and manipulation also increases their utility in drug discovery and their applicability for automation. A549 cells have been recently utilised to determine the anti-inflammatory properties of novel plant-based compounds (Henz Ryen et al, 2020). The carcinomic nature of A549 cells have directed their use for compound efficacy testing of novel anti-cancer treatments (Pokrovsky et al, 2019).…”

Section: D Cell-line Airway Modelsmentioning

confidence: 99%

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Recent advances in human respiratory epithelium models for drug discovery

Yaqub

Wayne

Birchall

et al. 2022

Biotechnology Advances

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Section: D Cell-line Airway Modelsmentioning

confidence: 99%

“…Furthermore, a potential anti-tumoral mechanism of action for the low-molecular weight heparin enoxaparin, was determined in A549 cells (Henz Ryen et al, 2020). The applicability of cancerous 2D cell lines to human physiology is inherently limited, yet such studies may be useful in narrowing the search for novel therapeutics.…”

Section: D Cell-line Airway Modelsmentioning

confidence: 99%

Recent advances in human respiratory epithelium models for drug discovery

Yaqub

Wayne

Birchall

et al. 2022

Biotechnology Advances

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“…Some compounds from a related species, L. obtusiloba, are notable for their therapeutic potential of antioxidative and pharmacological properties, which were also found in northern spicebush [13]. Three bisabolene sesquiterpenes isolated from L. benzoin leaves were observed to reduce the pro-inflammatory prostaglandin E2 formation in A549 cells [14]. At least 341 constituents, including sesquiterpenoids, alkaloids, butanolides, lucidones, flavonoids, and phenylpropanoids, were discovered in Lindera plants, and many of them have shown their potential in anticancer, antinociceptive, antiarthritic, and antinociceptive [15].…”

Section: Introductionmentioning

confidence: 99%

Genome Doubling of Northern Spicebush, Lindera benzoin L.

Arram,

Morgan,

Nix

et al. 2024

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Lindera benzoin is a dioecious understory shrub native to eastern North America. Northern spicebush is a beautiful shrub with a natural round shrub shape, golden-yellow fall foliage, attractive bright red drupes, and precocious yellow flowers in early spring; however, its market value as an ornamental value has been overlooked. To improve the ornamental values of this under-cultivated nursery crop, breeding for a better compact form, larger leaves, enlarged flower clusters and fruit, and increased stress tolerances could all be beneficial. Polyploidy manipulation is a valuable method to improve such traits for many ornamental plants. This study established the genome doubling method by oryzalin-infused solid agar treatment on young northern spicebush seedlings. The seedlings of two wild populations in North Carolina were collected and used. A total of 288 seedlings were treated with solid agar containing 150 µM oryzalin for 24, 72, and 120 h. The results were sporadic in their survival ratios and tetraploid conversion ratios between different treatments; however, a total of 16 tetraploid L. benzoin plants were produced in this study. The 24-h treatment showed the optimal result, with 7.1% of total treated seedlings or 15.2% of surviving seedlings converted into tetraploids. Tetraploid plants had visible differences in leaf morphology, a statistically significant enlarged stomata size, and reduced stomatal density compared to diploid plants. This research provides ploidy manipulation information for all future breeding processes of L. benzoin and related species.

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