Bisalbuminemia: A Rarely Encountered Protein Anomaly

Chhabra, Seema; Bansal, Frainey; Saikia, Biman; Minz, Ranjana Walker

doi:10.4103/0974-2727.119869

Cited by 15 publications

(8 citation statements)

References 5 publications

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“…The ICD-10 code E88.0 also includes bisalbuminaemia. This rarely encountered inherited or acquired serum protein anomaly is characterised by the condition of having two types of serum albumin that differ in mobility during electrophoresis, resulting in a bicuspid electrophoretic pattern in the albumin fraction detected on serum electrophoresis [16]. Because the condition is very rare and does not have clinical implications [17], we assumed that E88.0 is reflecting AATD rather than bisalbuminaemia.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of diagnosed α₁-antitrypsin deficiency and its comorbidities: results from a large population-based database

Greulich

Nell

Hohmann³

et al. 2016

Eur Respir J

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α-Antitrypsin deficiency (AATD) is a genetically determined disorder that is associated with different clinical manifestations. We aimed to assess the prevalence of diagnosed AATD and its comorbidities using a large healthcare database.In this retrospective longitudinal observational study, we analysed data from 4 million insurants. Using International Classification of Diseases revision 10 (ICD-10) codes, we assessed the prevalence, comorbidities and healthcare utilisation of AATD patients (E88.0 repeatedly coded) relative to non-AATD patients with chronic obstructive pulmonary disease (COPD), emphysema or asthma.In our study population, we identified 673 AATD patients (590 aged ≥30 years), corresponding to a prevalence of 23.73 per 100 000 in all age groups and 29.36 per 100 000 in those ≥30 years. Based on the number of AATD cases detected in the sample size (673 out of 2 836 585), we extrapolated that there were 19 162 AATD cases in Germany during the years studied. AATD patients had a higher prevalence of arterial hypertension, chronic kidney disease and diabetes relative to non-AATD asthma or emphysema patients. When compared to non-AATD COPD patients, AATD patients had significantly more consultations and more frequent and longer hospitalisations.Our data strengthen the assumption that AATD is associated with a variety of other diseases. Healthcare utilisation appears to be higher among AATD patients as compared to patients with non-AATD-related obstructive lung diseases.

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Section: Discussionmentioning

confidence: 99%

The prevalence of diagnosed α₁-antitrypsin deficiency and its comorbidities: results from a large population-based database

Greulich

Nell

Hohmann³

et al. 2016

Eur Respir J

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“…According to Chhabra et al 7 Direct immunofluorescence (DIF) is done using perilesional skin or mucosa as substrate whereas indirect immunofluorescence (IIF) is done using patient's serum. 7 In the current study, pemphigus vulgaris (45.9%) constituted the most common vesiculobullous disorder followed by bullous pemphigoid (29.1%) as in other studies by Fatma et al, Nanda et al and Deepti et al 2,8,9 The proportion of cases with pemphigus vulgaris and bullous pemphigoid were almost similar to that observed by Nanda et al, but higher than that observed in the study by Fatma et al, and Deepti et al 2,8,9 Pemphigus foliaceous was seen in only 3.6% of patients in our study which is in contrast to other studies like Fatma et al and Deepti et al 2,9 Overall, there was female preponderance in our study with a male to female ratio of 1:1.2, which is in par with other studies like Fatma et al and Deepti et al 2,9 In our study, most common age group affected was between 51 to 60 years of age, which is in approximately par with study by Fatma et al 2 Pemphigus is an intraepithelial immunobullous disease of the mucocutaneous system. Among the intraepidermal autoimmune vesiculobullous disorders, pemphigus vulgaris (76%) is the most common followed by pemphigus vegetans (6%), and pemphigus erythematosus (6%).…”

Section: Epidermolysis Bullosa Acquisitamentioning

confidence: 99%

A retrospective study on clinical and demographic features of autoimmune vesiculobullous disorders from a rural tertiary care institute in Tamil Nadu

et al. 2019

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Background: Autoimmune vesiculobullous disorders are a heterogenous group of skin diseases in which autoantibodies are directed against cell adhesion molecules which are essential for the integrity of skin and oral mucosa. They are clinically characterized by the presence of vesicles, bullae or erosions over the skin and/ or mucosa depending on the antibodies involved. They are divided into intraepidermal and subepidermal based on the location of the bulla. Among intraepidermal bullous disorders, pemphigus vulgaris (PV) is most common. Bullous pemphigoid (BP) is the most common among the subepidermal bullous disorders. Although they occur worldwide, the incidence shows geographical variation. A retrospective study was carried out with the objective to analyse the clinical and demographic profile of patients with autoimmune vesiculobullous disorders among patients attending a tertiary care teaching hospital in a rural setup.Methods: A total of 137 case sheets were audited from the Medical Records Department of our institute. Details were collected and tabulated, compiled and analysed.Results: Out of the 137 cases studied, intraepidermal autoimmune vesiculobullous disorders accounted for 63.4% of cases, and subepidermal autoimmune vesiculobullous disorders accounted for 36.6% of cases. Out of the 137 cases, 74 patients (54%) were females, and 63 patients (46%) were males. Majority of the patients were in the age group of 51-60 years (29.9%), followed by 41-50 years (24.1%) and 61-70 years (17.5%).Conclusions: Pemphigus vulgaris was the most common among the intraepidermal autoimmune vesiculobullous disorders, and bullous pemphigoid was the most common among the subepidermal autoimmune vesiculobullous disorders.

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“…Bisalbuminaemia is characterised by the occurrence of a bicuspid electrophoretic pattern in the albumin fraction, where albumin produces two heads (bands of equal or unequal intensity; Chhabra et al 2013). In this abnormality, albumin may either have increased (fast type variants), or decreased electrophoretic mobility (slow type variants; Kobayashi et al 1995).…”

Section: Albuminmentioning

confidence: 99%

Serum proteins and their diagnostic utility in veterinary medicine: a review

Tóthová¹,

Nagy²,

Kováč³

2016

Vet. Med.

134

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ABSTRACT:The evaluation of serum proteins and their electrophoretic pattern is a well-established laboratory method in the diagnosis of many diseases in humans, which has replaced the biochemical determination of the concentrations of albumin and the ratio of albumin to globulins. The measurement of serum proteins may be an important diagnostic tool for the detection, diagnosis, and monitoring of various diseases and pathological processes. The results of serum protein electrophoresis can be one of the most useful diagnostic aids in a wide spectrum of diseases, including infectious and inflammatory diseases, renal or gastrointestinal disorders, immunodeficiency states, as well as paraproteinaemias caused by lymphoid or plasma cell neoplasia. Although many studies have been carried out to determine the usefulness of the determination of serum proteins and their electrophoretic pattern in various disease conditions and disorders also in animals, serum protein evaluation is still a relatively little-used diagnostic tool in veterinary medicine. In this article, methods of serum protein determination, their diagnostic utility in animal care practice and their different patterns in dysproteinaemias and paraproteinaemias are reviewed.

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Bisalbuminemia: A Rarely Encountered Protein Anomaly

Cited by 15 publications

References 5 publications

The prevalence of diagnosed α₁-antitrypsin deficiency and its comorbidities: results from a large population-based database

The prevalence of diagnosed α₁-antitrypsin deficiency and its comorbidities: results from a large population-based database

A retrospective study on clinical and demographic features of autoimmune vesiculobullous disorders from a rural tertiary care institute in Tamil Nadu

Serum proteins and their diagnostic utility in veterinary medicine: a review

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Bisalbuminemia: A Rarely Encountered Protein Anomaly

Cited by 15 publications

References 5 publications

The prevalence of diagnosed α1-antitrypsin deficiency and its comorbidities: results from a large population-based database

The prevalence of diagnosed α1-antitrypsin deficiency and its comorbidities: results from a large population-based database

A retrospective study on clinical and demographic features of autoimmune vesiculobullous disorders from a rural tertiary care institute in Tamil Nadu

Serum proteins and their diagnostic utility in veterinary medicine: a review

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The prevalence of diagnosed α₁-antitrypsin deficiency and its comorbidities: results from a large population-based database

The prevalence of diagnosed α₁-antitrypsin deficiency and its comorbidities: results from a large population-based database