Bisalbuminemia in chronic kidney disease

Ejaz, A. Ahsan; Krishna, Murli; Wasiluk, Andrew; Knight, J.

doi:10.1007/s10157-004-0291-1

Cited by 17 publications

(12 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Taking into account the electrophoretic mobility and high abundance of both protein peaks, we suggest that these individuals have bisalbuminemia, similar to what occurs in subspecies of Salamandra 15 . Bisalbuminemia has been well described in humans and can be either hereditary or acquired 16 . In iguanas, bisalbuminemia probably has a genetic origin, based on the symmetric shape of the double peak and its lack of association with a specific disease or pharmacological treatment.…”

Section: Discussionmentioning

confidence: 99%

Plasma protein electrophoresis ofTrachemys scriptaandIguana iguana

Giménez

Saco²,

Pato³

et al. 2010

Veterinary Clinical Pathol

View full text Add to dashboard Cite

Background: Protein electrophoresis is widely applied in veterinary medicine, but is not used often in reptiles, in part because of lack of reference values. Objective: The goals of this study were to compare plasma protein profiles obtained by cellulose acetate electrophoresis (CAE) and agarose gel electrophoresis (AGE), measure precision and examine interference by sample hemolysis, and establish preliminary reference intervals for 2 reptile species. Methods: Heparinized plasma samples from healthy and diseased adult female Iguana iguana (n = 40) and Trachemys scripta (n = 60) were analyzed by CAE and AGE. Total protein concentration was measured by the biuret method. Electrophoresis results were compared using Bland-Altman plots and Passing-Bablok regression analysis. Precision and the effects of sample hemolysis were determined. Results from clinically healthy animals were used to determine reference intervals. Results: Five protein fractions were identified in both species, with bisalbuminemia observed in 23/40 iguanas. High correlation was observed between the 2 methods for all fractions, with few proportional and systematic errors. Coefficients of variation were lower using AGE vs CAE and for I. iguana vs T. scripta. Two additional bands were observed in hemolyzed samples from T. scripta; 1 additional band was observed for I. iguana. Minimum and maximum values were reported for healthy I. iguana (n = 14) and T. scripta (n = 22). Conclusions: Although both methods are acceptable, the performance of AGE was slightly better than that of CAE for analysis of plasma from reptiles. Furthermore, reptile electrophoretic patterns should be interpreted based on the method used, the species analyzed, and the quality of the plasma sample.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma protein electrophoresis ofTrachemys scriptaandIguana iguana

Giménez

Saco²,

Pato³

et al. 2010

Veterinary Clinical Pathol

View full text Add to dashboard Cite

show abstract

“…In this abnormality, albumin may either have increased (fast type variants), or decreased electrophoretic mobility (slow type variants; Kobayashi et al 1995). In humans, bisalbuminaemia has been described in some pathological conditions, including chronic renal diseases, nephrotic syndrome, diabetes mellitus, pancreatic doi: 10.17221/19/2016-VETMED disease or Alzheimer's disease (Ejaz et al 2004;Shetty et al 2007). In animals, bisalbuminaemia was found in female bottlenose dolphin (Turiops truncatus), but it was not associated with disease (Medway 1979).…”

Section: Albuminmentioning

confidence: 99%

Serum proteins and their diagnostic utility in veterinary medicine: a review

Tóthová¹,

Nagy²,

Kováč³

2016

Vet. Med.

134

View full text Add to dashboard Cite

ABSTRACT:The evaluation of serum proteins and their electrophoretic pattern is a well-established laboratory method in the diagnosis of many diseases in humans, which has replaced the biochemical determination of the concentrations of albumin and the ratio of albumin to globulins. The measurement of serum proteins may be an important diagnostic tool for the detection, diagnosis, and monitoring of various diseases and pathological processes. The results of serum protein electrophoresis can be one of the most useful diagnostic aids in a wide spectrum of diseases, including infectious and inflammatory diseases, renal or gastrointestinal disorders, immunodeficiency states, as well as paraproteinaemias caused by lymphoid or plasma cell neoplasia. Although many studies have been carried out to determine the usefulness of the determination of serum proteins and their electrophoretic pattern in various disease conditions and disorders also in animals, serum protein evaluation is still a relatively little-used diagnostic tool in veterinary medicine. In this article, methods of serum protein determination, their diagnostic utility in animal care practice and their different patterns in dysproteinaemias and paraproteinaemias are reviewed.

show abstract

“…Bisalbuminemia is an inherited or acquired condition with a worldwide cumulative population frequency of [3]. About 77 mutations of albumin gene are known so far and 65 of them were result of bisalbuminemia [4].…”

Section: Discussionmentioning

confidence: 99%

“…Although possibility that some physiologic or pharmacologic substances may not bind to abnormal albumin variant as well as they bind to normal albumin variants as well as they bind to normal albumin should not be discounted [3] In Indian context, Dash et al, found 2 out of 1000 cases screened for bisalbuminemia in Punjabi population [7] Jamal et al, reported two cases of bisalbuminemia in 3000 consecutive electrophoresis in their lab and Simundic A, et al, found about 8 cases of bisalbuminemia in 6500 capillary electrophoresis [4,8].…”

Section: Discussionmentioning

confidence: 99%

Bisalbuminemia in a Hypothyroid Patient with Diabetes: A Case Report

Shetty

Maradi

Prabhu

et al. 2015

JCDR

View full text Add to dashboard Cite

A 61-year-old female was admitted to Kasturba Hospital Manipal with one week history of fever, cough and low backache. She was apparently doing well till one week before admission when suddenly she developed fever, which was insidious in onset and gradually progressive with intermittent high grade without chills or rigors. She also complained of dry cough since one week. This had progressed to severe cough with difficulty in breathing which was relieved by inhalers in two days. She also had a progressive back ache which gets aggravated by sitting and walking. She was a hypertensive for last 12 years and underwent thyroidectomy 12 years back. She also was diagnosed with diabetes mellitus and bronchitis since two years and was on regular treatment with oral hypoglycemic drugs and inhalers. On examination she was conscious, her vitals were stable, temperature 37.3 o C, her BP and pulse was 150/100 mmHg, 80/ min respectively. No abnormality was observed in general physical examination other than presence of a thyroidectomy scar. On respiratory examination, she had bilateral rhonchi, cardiovascular system and abdominal examination does not reveal any abnormality. Laboratory reports Haemoglobin 12.4 g/dl, hematocrit 35.9%, platelets 402 x 10 3 /µl, total WBC 10.2 x10 3 /µl, neutrophils 62.3 %, lymphocytes 29.7 %, monocytes 5.9 %, basophils 0.6 %, urea 18 mg/dl, creatinine 0.6 g/dl, total cholesterol 233 mg/dl, triglycerides 213 mg/dl, HDL 34 mg/dl, LDL 156 mg/dl, FBS 139 mg/dl, PPBS 196 mg/dl, QBC malaria negative, AST, ALT, ALP, electrolytes, calcium and phosphorous -all within normal limits. TSH was elevated (8.08 µIU/ml), total protein 8.3g/dl with albumin to globulin ratio of 1.24, and elevated gamma globulin concentration (1.7 g/dl). Protein electrophoresis done using Helena semi-automated electrophoretic instrument with densitometer [Table/ Fig-1] showed two distinct unequal albumin bands. Among the two band of albumin, slow moving and normal band concentrations were 43% and 57% of total albumin, respectively. She was empirically treated for acute exacerbation of bronchial asthma with antibiotics (azithromycin) and she improved and discharged with advice to follow up after one month. DisCussionBisalbuminemia is a rarely encountered anomaly characterized by presence of bifid albumin bands or a single widened albumin band in electrophoretogram. Bisalbuminemia is an inherited or acquired condition with a worldwide cumulative population frequency of Bisalbuminemia is a rarely encountered anomaly characterized by presence of bifid albumin bands or a single widened albumin band in electrophoretogram. Inherited bisalbuminemia is quite rare and inherited as an autosomal dominant form. The acquired form of bisalbuminemia is usually transient and may be observed during long term beta lactam antibiotic therapy, acute pancreatitis, myeloma and nephrotic syndrome. This is a case of bisalbuminemia in 61-year-old diabetic female with hypothyroidism came with acute exacerbation of bronchial asthma.

show abstract

Bisalbuminemia in chronic kidney disease

Cited by 17 publications

References 3 publications

Plasma protein electrophoresis ofTrachemys scriptaandIguana iguana

Plasma protein electrophoresis ofTrachemys scriptaandIguana iguana

Serum proteins and their diagnostic utility in veterinary medicine: a review

Bisalbuminemia in a Hypothyroid Patient with Diabetes: A Case Report

Contact Info

Product

Resources

About