Bisbenzylisoquinoline alkaloids of lotus ( Nelumbo nucifera Gaertn.) seed embryo inhibit lipopolysaccharide-induced macrophage activation via suppression of Ca ²⁺ -CaM/CaMKII pathway

Abstract

Bin Xu (2019) Bisbenzylisoquinoline alkaloids of lotus (Nelumbonucifera Gaertn.) seed embryo inhibit lipopolysaccharide-induced macrophage activation via suppression of Ca 2+

Inhibitory Effect of Lotusine on Solar UV-Induced Matrix Metalloproteinase-1 Expression

“…Nelumbo nucifera has been employed for edible or medicinal purposes, using various parts such as flowers, leaves, stems, and seeds [ 13 ]. Since ancient times, it has been used as an obstipatic, diuretic, antipyretic, and antibacterial agent.…”

“…Lotusine, a phytochemical and soluble alkaloid, has been shown to dilate blood vessels and reduce blood pressure. In addition, lotusine can reduce intestinal motility and relieve diarrhea and has shown antispasmodic and beneficial cardiac properties [ 13 ]. It also eliminates pathogenic fever and spontaneous bleeding from the heart [ 26 ].…”

“…Nelumbo nucifera is a well-known edible plant widely grown in Korea, China, and Japan [ 13 ]. Nelumbo nucifera is composed of flowers, leaves, stems, and seeds.…”

“…Recently, Nelumbo nucifera lotus flower extract has been widely used in cosmetic preparations owing to its ability to reduce wrinkles and its whitening properties [ 17 ]. Currently, several cosmetics using Nelumbo nucifera lotus embryo extracts are commercially available [ 13 ]. However, the active components of lotus embryos need to be elucidated.…”

Challenges and future directions of potential natural products leads against 2019-nCoV outbreak

“…Interestingly, bis -benzylisoquinoline alkaloids are enriched in several well-known edible plants such as Nelumbo nucifera (lotus) which is widely cultivated in Asia [ 17 ]. Tetrandrine ( 1 ) and fangchinoline ( 2 ) showed in vitro antiviral activity against human coronavirus [ 18 ]. The expression levels of the S- and N -proteins in MRC-5 lung human cells infected with HCoV−OC43 at two days’ post-infection were significantly diminished and virus replication was suppressed by the action of alkaloids 1-3 .…”