Bisindole natural products: A vital source for the development of new anticancer drugs

Suadimins D—J, Monoterpenoid Indole‐Quinoline and Bisindole Alkaloids from Melodinus suaveolens

“…), were isolated and identified from Apocynaceae [Figure S1, Supporting Information (SI)]. [1][2][8][9][10] The plant genus Melodinus (Apocyanceae) houses approximately 50 species, which was reported as being a rich source of the anticancer conjugates of monoterpenoid bisindole, bisquinoline, and indole-quinoline alkaloids. [2,5,[11][12][13] The plant species of M. suaveolens is distributed mainly in the tropical and subtropical area of Asia, which have been used as ethnic remedy for the treatment of abdominal pain, infantile malnutrition, indigestion, scrofula, and hernia.…”

“…The monoterpenoid bisindole, bisquinoline, and indole‐quinoline alkaloids are a class of intriguing natural products, of which different monoterpenoid indole and quinoline alkaloids (MIAs and MQAs) are conjugated through various linkages. [ 1‐3 ] These dimeric alkaloids have been a topic of immense interest to scientific communities of synthetic chemists and biologists, due to the complex structural architectures and their potential anticancer, [ 1 ] immunosuppressive, [ 4 ] and anti‐diabetic nephropathy [ 5 ] activities. The family Apocynaceae contains about 250 genera and 2000 species of tropical trees, shrubs, woody climbers, and herbs, [ 6 ] which is one of the major plant family of MIAs, MQAs, and their conjugates.…”

Chiral phosphoric acid-catalyzed chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with 4-aminoindoles at the C7 position

“…4a,5 As one of the most direct and efficient methods for the synthesis of functionalized indole derivatives, extensive efforts have been made on the asymmetric Friedel-Crafts alkylation of indoles over the last two decades, 6 which include the catalytic enantioselective addition of indoles to electrophilic oxindole derivatives that could afford biologically interesting chiral bisindoles. 7 Many oxindole-derived electrophiles were designed and applied in this process. In the case of reaction between indoles and isatin-derived β,γ-unsaturated α-ketoesters, only 1,4-addition products and their cyclization derivatives were obtained to give the corresponding 3,3-or 2,3bisindole derivatives.…”

Interactions between curcumin and human salt-induced kinase 3 elucidated from computational tools and experimental methods

“…Natural products have many notable characteristics, such as wide efficacy and low toxicity; they have recently attracted increasing research attention as lead compounds to treat mitochondrial dysfunction-related diseases, cancer, and antimicrobial-resistant infections ( Du et al, 2021 ; An et al, 2022 ; Rahman M. A. et al, 2022 ; Bernal et al, 2022 ; Rahman M. M. et al, 2022 ; He et al, 2022 ; Liao et al, 2022 ; Nurumal et al, 2022 ; Su et al, 2022 ; Xu et al, 2022 ). Especially, the effects of many natural product on mitochondrial dysfunction-related diseases have been recently studied ( An et al, 2022 ; Rahman M. A. et al, 2022 ; Rahman M. M. et al, 2022 ).…”