Bismuth-catalyzed arylation of ethyl glyoxylate with aniline via N–H insertion

Bismuth‐catalyzed N‐Arylation of 2‐Aminobenzimidazole and Phosphorylation of Substituted Coumarins via C−H functionalization

“…We present bismuth chloride as an alternative catalyst for the selective C−NH 2 ‐arylation of 2‐aminobenzimidazoles under ligand‐free conditions. Compared to the other metal salts, trichloro bismuth offers unique qualities such as low toxicity, cheap, high efficiency, [1] and tolerance to a small quantity of water. To the best of our knowledge, no one has documented the bismuth‐catalyzed Chan–Lam coupling reaction of aminoazoles and boronic acids.…”

“…CÀ N bond formation is essential in organic chemistry due to the ubiquitous presence of nitrogencontaining functional groups in synthetic building blocks and biologically active compounds. [1] Chan and Lam devised effective techniques for producing N-arylazoles using coppermediated catalysts to create CÀ N bonds by the cross-coupling of arylboronic acids and azoles. [2] N-arylated 2-aminobenzimidazoles, notably CÀ NH 2 arylated 2-aminobenzimidazoles, are favored heterocyclic class found in a wide range of medicinally relevant drugs, including Tie-2 kinase inhibitors, [3] aurora kinase inhibitors, [4] and integrin antagonists.…”

“…The significance of aromatic C−N bonds in pharmaceuticals and natural products has drawn much interest in developing efficient methodologies. C−N bond formation is essential in organic chemistry due to the ubiquitous presence of nitrogen‐containing functional groups in synthetic building blocks and biologically active compounds [1] . Chan and Lam devised effective techniques for producing N‐arylazoles using copper‐mediated catalysts to create C−N bonds by the cross‐coupling of arylboronic acids and azoles [2] .…”