Bismuth in human serum: reference interval and concentrations after intake of a therapeutic dose of colloidal bismuth subcitrate

Vanhoe, Hans; Versieck, Jacques; Vanballenberghe, L; Dams, Richard

doi:10.1016/0009-8981(93)90199-e

Cited by 29 publications

(12 citation statements)

References 20 publications

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“…The half-life of bismuth in blood may be as short as 3.5 min and as long as 17-22 years [5,22]. Bismuth concentration is highest in the kidneys, where it binds to a bismuth-metal binding protein [5].…”

Section: Discussionmentioning

confidence: 99%

Reversible nephrotoxicity after overdose of colloidal bismuth subcitrate

İşlek

Uysal

Gök

et al. 2001

Pediatric Nephrology

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Although toxicity due to acute and chronic use of bismuth salts is well known, nephrotoxicity after ingestion of colloidal bismuth has been reported in few cases so far. Here we report the first case of acute renal failure (ARF) due to colloidal bismuth subcitrate overdosage in childhood. A 2-year-old boy was admitted to the hospital 6 h after ingestion of 28 De-Nol tablets (colloidal bismuth subcitrate 8.4 g). On admission, physical examination was unremarkable and he showed no signs of encephalopathy. Initially gastric lavage was performed then appropriate fluid therapy was started. ARF associated with uremia and oliguria developed on day 2 and peritoneal dialysis therapy was prescribed on day 4 for 10 days. Blood and urine bismuth levels were 739 micrograms/l and 693 micrograms/l, respectively, 10 days after the pills had been taken. His urine volume gradually increased and plasma BUN and creatinine levels decreased during peritoneal dialysis. On day 20 post-admission, plasma BUN and creatinine were 14 mg/dl and 0.7 mg/dl, respectively. Blood bismuth levels were 96 micrograms/l on day 60 and 12 micrograms/l on day 105. Now the patient is well and has no problem. This case suggests that ARF may develop in children following colloidal bismuth subcitrate overdosage; the prognosis is good, and peritoneal dialysis may be useful in these cases.

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Section: Discussionmentioning

confidence: 99%

Reversible nephrotoxicity after overdose of colloidal bismuth subcitrate

İşlek

Uysal

Gök

et al. 2001

Pediatric Nephrology

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show abstract

“…They reported transient reduction in blood bismuth concentration after HD, and they attributed this to redistribution from tissue stores. It can be as short as 3.5 min and as long as 17-22 years (3,17). Islek et al (10) reported a 2year-old patient with colloidal bismuth overdose who was treated with PD alone.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury Associated with Rapid Treatment of Hemodiafiltration for Bismuth Intoxication: Update and Review of the Literature

2013

J Turgut Ozal Med Cent

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“…253 Vanhoe et al used inductively coupled plasma-mass spectrometry to demonstrate minute amounts (0.007-0.067 mg l -1 ) of bismuth in the serum of 19 healthy patients. 254 Much higher levels of 242 mg l -1 measured in a patient treated with bismuth subcitrate (Pepto-Bismol s ) for irritable bowel syndrome show that the element is absorbed gastrointestinally. 255 This patient was hospitalised with bismuth-related dementia.…”

Section: Human Exposurementioning

confidence: 98%

CHAPTER 17. Arsenic, Antimony and Bismuth

2013

Issues in Toxicology

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Bismuth in human serum: reference interval and concentrations after intake of a therapeutic dose of colloidal bismuth subcitrate

Cited by 29 publications

References 20 publications

Reversible nephrotoxicity after overdose of colloidal bismuth subcitrate

Reversible nephrotoxicity after overdose of colloidal bismuth subcitrate

Acute Kidney Injury Associated with Rapid Treatment of Hemodiafiltration for Bismuth Intoxication: Update and Review of the Literature

CHAPTER 17. Arsenic, Antimony and Bismuth

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