Bisphenol A affects ovarian development in adolescent mice caused by genes expression change

Wu, Fengrui; Zhao, Jing; Zhang, Enyu; Wu, Qingqing; Wu, Xiaoqing; Zhang, Di; Liu, Yong; Wang, Rong; Li, Wenyong

doi:10.1016/j.gene.2020.144535

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…Another study examined the impact of BPA on the ovarian development of mice [17]. The study found that increased exposure to BPA led to many changes, including ovarian structural and developmental changes and a total of 4266 differentially expressed genes [17]. On the basis of these and numerous other studies, it has been concluded that BPA exposure can have a negative impact on female reproduction.…”

Section: Endocrine-disrupting Chemicals and Other Toxins In Water And...mentioning

confidence: 99%

“…Urinary BPA concentration was shown to be negatively associated with serum concentrations of AMH (anti-M€ ullerian hormone) and with AFC (antral follicle count), two parameters used to determine ovarian follicular reserve [16]. Another study examined the impact of BPA on the ovarian development of mice [17]. The study found that increased exposure to BPA led to many changes, including ovarian structural and developmental changes and a total of 4266 differentially expressed genes [17].…”

Section: Endocrine-disrupting Chemicals and Other Toxins In Water And...mentioning

confidence: 99%

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The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Seli

Taylor

2023

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewRapid increase in world population accompanied by global industrialization has led to an increase in deployment of natural resources, resulting in growing levels of pollution. Here, we review recent literature on the impact of environmental pollution on human reproductive health and assisted reproduction outcomes, focusing on two of the most common: air pollution and endocrine disruptors. Recent findingsAir pollution has been associated with diminished ovarian reserve, uterine leiomyoma, decreased sperm concentration and motility. Air pollution also correlates with decreased pregnancy rates in patients undergoing infertility treatment using in-vitro fertilization (IVF). Similarly, Bisphenol A (BPA), a well studied endocrine disrupting chemical, with oestrogen-like activity, is associated with diminished ovarian reserve, and abnormal semen parameters, while clinical implications for patients undergoing infertility treatment remain to be established. SummaryThere is convincing evidence that environmental pollutants may have a negative impact on human health and reproductive potential. Air pollutions and endocrine disrupting chemicals found in water and food seem to affect male and female reproductive function. Large-scale studies are needed to determine the threshold values for health impact that may drive targeted policies.

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Section: Endocrine-disrupting Chemicals and Other Toxins In Water And...mentioning

confidence: 99%

Section: Endocrine-disrupting Chemicals and Other Toxins In Water And...mentioning

confidence: 99%

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Seli

Taylor

2023

Current Opinion in Obstetrics &Amp; Gynecology

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“…Bisphenol A has become one of the most intensively manufactured chemicals in the world due to demonstrating the finest properties for plastic production (Noszczyńska and Piotrowska-Seget 2018). Numerous studies have investigated BPA effects on the human body and animals (Zhu et al 2015;Quesada et al 2002;Braun et al 2009;Izzotti et al 2009;Pfeifer et al 2015;Leung et al 2017;Maćczak et al 2017;Pinney et al 2017;Tian et al 2018;Grandin et al 2019;Özel et al 2019;Gao et al 2020;Rasdi et al 2020;Tassinari et al 2020;Wu and Seebacher 2020;Wu et al 2020a;Pan et al 2020). Since BPA has a comparable structure to that of natural estrogen 17β-estradiol, it can bind to ERα and ERβ, though with 1000-fold less affiliation than estradiol (Gray et al 2004;vom Saal and Hughes 2005;Takayanagi et al 2006;Gray et al 2004;vom Saal and Hughes 2005;Takayanagi et al 2006).…”

Section: Endocrine-disrupting Chemicalsmentioning

confidence: 99%

White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater

Grelska

Noszczyńska

2020

Environ Sci Pollut Res

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Endocrine-disrupting chemicals (EDC) are a wide group of chemicals that interfere with the endocrine system. Their similarity to natural steroid hormones makes them able to attach to hormone receptors, thereby causing unfavorable health effects. Among EDC, bisphenol A (BPA), bisphenol S (BPS), and nonylphenol (NP) seem to be particularly harmful. As the industry is experiencing rapid expansion, BPA, BPS, and NP are being produced in growing amounts, generating considerable environmental pollution. White rot fungi (WRF) are an economical, ecologically friendly, and socially acceptable way to remove EDC contamination from ecosystems. WRF secrete extracellular ligninolytic enzymes such as laccase, manganese peroxidase, lignin peroxidase, and versatile peroxidase, involved in lignin deterioration. Owing to the broad substrate specificity of these enzymes, they are able to remove numerous xenobiotics, including EDC. Therefore, WRF seem to be a promising tool in the abovementioned EDC elimination during wastewater treatment processes. Here, we review WRF application for this EDC removal from wastewater and indicate several strengths and limitations of such methods.

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“…Particularly, it has been demonstrated that BPA is an ovarian toxicant and might be associated with disrupted estrous cyclicity, higher risk of miscarriage, or polycystic ovarian syndrome (Lathi et al 2014;Peretz et al 2014;Ziv-Gal and Flaws 2016). Experimental administration and exposure to BPA have revealed alterations in ovarian development and functions through impact on ovarian anatomy and histology (Wu et al 2020). Considerably, environmentally relevant doses of BPA may modulate the gene expression profile in the epithelial ovarian cancer cells (Hui et al 2018).…”

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confidence: 99%

Expression of selected nuclear receptors in human epithelial ovarian cell line Caov3 exposed to bisphenol derivatives

Mlynarcikova,

Macejova,

Scsukova

2023

Endocrine Regulations

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Objectives. Bisphenol A (BPA) is an indispensable industrial chemical. However, as a proven endocrine disruptor, it may be associated with several health disturbances, including the reproductive functions impairment and cancer. Due to the restriction of BPA usage, many bisphenol derivatives gradually substitute BPA. However, studies have reported adverse biological effects of BPA analogs, but the specific sites of their action remain largely unknown. Nuclear receptors (NRs) appear to play significant roles in various types of cancer. In addition, they are considered relevant targets of bisphenols. In the present study, we investigated the effects of BPA and its analogs bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF) on mRNA expression of selected NRs in the human ovarian epithelial cell line Caov3. The NRs examined included retinoic acid receptor α (RARA), retinoid X receptor α (RXRA), peroxisome proliferator activating receptor β/δ (PPARD), chicken ovalbumin upstream promoter-transcription factor 2 (COUPTFII), and nuclear receptor-related protein 1 (NURR1). Methods. Caov3 cells were treated with the bisphenols at the concentrations of 1 nM, 100 nM, 10 µM and 100 µM. After 24 h and 72 h of incubation, cell viability was determined by the MTS assay, and the selected genes expression was analyzed using RT-qPCR. Results. Bisphenol treatment did not affect Caov3 cell viability, except the significant impairment after exposure to the highest BPAF dose (100 µM). At lower doses, neither bisphenol analog altered the expression of the NRs. However, at the highest concentration (100 µM), BPAF and BPA altered the mRNA levels of PPARD, COUPTFII, and NURR1 in a time- and receptor-specific manner. Conclusions. The effects of bisphenols on the specific NRs in the epithelial ovarian cancer cells were addressed for the first time by the present study. Although generally we did not find that bisphenols may provoke significant alterations in the expression of the selected NRs in Caov3 cells, they may alter mRNA expression of certain NRs at high concentrations.

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Bisphenol A affects ovarian development in adolescent mice caused by genes expression change

Cited by 12 publications

References 36 publications

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater

Expression of selected nuclear receptors in human epithelial ovarian cell line Caov3 exposed to bisphenol derivatives

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