Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas

Canesi, Laura; Borghi, C.; Ciacci, Caterina; Fabbri, Rita; Vergani, Laura; Gallo, Gabriella

doi:10.1016/j.mce.2007.06.002

Cited by 86 publications

(35 citation statements)

References 62 publications

(111 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus the findings of Canesi et al (2007a) may have significant implications for mussel health. Canesi et al (2007b) also reported altered patterns of gene expression and activity of enzymes involved in the redox balance following an injection of BPA into the posterior adductor muscle (at nominal doses of 3, 15 and 60 ng BPA g 21 dry wt.). In the digestive gland, an increased expression of the Mytilus ER (MeER2) was observed at the lowest test concentration 24 h after injection, whereas results for the higher test concentrations were not significant.…”

mentioning

confidence: 94%

A critical analysis of the biological impacts of plasticizers on wildlife

Oehlmann

Schulte‐Oehlmann

Kloas

et al. 2009

Phil. Trans. R. Soc. B

760

341

View full text Add to dashboard Cite

This review provides a critical analysis of the biological effects of the most widely used plasticizers, including dibutyl phthalate, diethylhexyl phthalate, dimethyl phthalate, butyl benzyl phthalate and bisphenol A (BPA), on wildlife, with a focus on annelids (both aquatic and terrestrial), molluscs, crustaceans, insects, fish and amphibians. Moreover, the paper provides novel data on the biological effects of some of these plasticizers in invertebrates, fish and amphibians. Phthalates and BPA have been shown to affect reproduction in all studied animal groups, to impair development in crustaceans and amphibians and to induce genetic aberrations. Molluscs, crustaceans and amphibians appear to be especially sensitive to these compounds, and biological effects are observed at environmentally relevant exposures in the low ng l 21 to mg l 21 range. In contrast, most effects in fish (except for disturbance in spermatogenesis) occur at higher concentrations. Most plasticizers appear to act by interfering with the functioning of various hormone systems, but some phthalates have wider pathways of disruption. Effect concentrations of plasticizers in laboratory experiments coincide with measured environmental concentrations, and thus there is a very real potential for effects of these chemicals on some wildlife populations. The most striking gaps in our current knowledge on the impacts of plasticizers on wildlife are the lack of data for long-term exposures to environmentally relevant concentrations and their ecotoxicity when part of complex mixtures. Furthermore, the hazard of plasticizers has been investigated in annelids, molluscs and arthropods only, and given the sensitivity of some invertebrates, effects assessments are warranted in other invertebrate phyla.

show abstract

mentioning

confidence: 94%

A critical analysis of the biological impacts of plasticizers on wildlife

Oehlmann

Schulte‐Oehlmann

Kloas

et al. 2009

Phil. Trans. R. Soc. B

760

341

View full text Add to dashboard Cite

show abstract

“…The major injury known for BPA is the endocrine disruption [4,17]. The evaluation of the ALP detected this typical effect − the increase of the level of these vitellogenin-like proteins in the gonads of male specimens, despite in the hemolymph their level was not changed by exposure.…”

Section: таблиця 3 біомаркери токсичності у травній залозі (Dg) гемmentioning

confidence: 95%

“…The evaluation of the ALP detected this typical effect − the increase of the level of these vitellogenin-like proteins in the gonads of male specimens, despite in the hemolymph their level was not changed by exposure. The endocrine disruptive effects of BPA were shown earlier in marine mussels affecting significantly their reproduction [1,4].…”

Section: таблиця 3 біомаркери токсичності у травній залозі (Dg) гемmentioning

confidence: 99%

“…They typically cannot be removed even by modern wastewater treatment plants [11]. Previously we studied the effect of typical PPCPs, calcium influx inhibitor nifedipine (Nfd), which is widely used as a cheap antianginal and antihypertensive medicine and is a common pollutant in the surface waters [13], and common product eluted from the polycarbonate plastics, Bisphenol A (BPA), recognized endocrine disruptor [4,20], on the nontarget organism, bivalve mollusk [6,9]. Cachannel blocker Nfd affected intracellular Zn distribution with the prominent elevation of its binding with metallothioneins and caused reductive stress indicated by elevated levels of reduced glutathione levels and an increase in lactate/ pyruvate ratio [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multi-marker study of the response of bivalve mollusk Unio tumidus induced by the compounds of typical municipal effluents

Gnatyshyna¹,

Falfushynska²,

Mykhalska³

et al. 2017

Biol. Stud.

View full text Add to dashboard Cite

The pharmaceutical and personal care products (PPCPs) became the most typical pollutants of the surface waters. The aim of this study was to evaluate the effects of the combine exposure to the common compounds of the municipal effluents, constituent of plastics bisphenol A (BPA) and popular medicine nifedipine (Nfd), on the model orga nism, a mussel Unio tumidus. Male U. tumidus were exposed for 14 days to the com bination of Nfd (10 μM) and BPA (0.88 nM). The indices of oxidative stress, metabolic, immune and endocrine activity, metal balance, as well as the manifestations of toxicity were detected. The exposure caused the features known for the effect of Nfd: the ac tivation of the oxidative stress response, particularly Cu,Znsuperoxide dismutase (by 6.0 times), glutathione and oxyradical levels, metabolic shift to the anaerobiosis due to the elevated level of lactate in the digestive gland. The manifestation of endocrine dis ruption typical for the BPA effect the increased level of alkalilabile phosphates (vitel logeninlike proteins) in gonads was detected. The caspase3 related apoptotic activity was suppressed; whereas the cathepsin D mediated proteolysis and immune response of phenoloxidase were up-regulated significantly. The signs of geno-, neuro-and cyto toxicity were detected. These results detect that the approximation of the experimental conditions to the environmentally realistic situation could assist the comprehensive fore casting of the effects of utilized PPCPs for the aquatic animals.

show abstract

“…Interestingly, for prosobranch snails, bisphenol A can induce ''superfemale'' development characterized by formation of additional female organs, enlargement of accessory glands, malformations of oviducts, massive stimulation of oocytes and spawning (Oehlmann et al 2000;Jobling et al 2003), and increases in the number of embryos sheltered in the brood pouch (Duft et al 2003). Bivalves may also be affected by bisphenol A: injection of bisphenol A into Mytilus alters antioxidant levels, decreases lysosomal membrane stability and increases neutral lipid accumulation in the hepatopancreas (Canesi et al 2007), and modulates kinase-mediated signaling pathways (Canesi et al 2004). Zebra mussels exposed to effluent from a municipal sewage treatment works (containing bisphenol A) have increased vitellin-like proteins and alterations in morphology of male genitalia (Quinn et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Effects of bisphenol A in the ring-legged earwig, Euborellia annulipes

Rankin

Grosjean

2009

Ecotoxicology

View full text Add to dashboard Cite

Bisphenol A is a known endocrine disruptor in vertebrates that mimics the action of estrogens by interacting with hormone receptors. It also affects reproduction and development in many invertebrate animals, though mechanisms of action are unclear. Terrestrial insects, despite their abundance and profound ecological significance, have been largely overlooked as a group that might be affected by vertebrate endocrine disrupting chemicals. We evaluated potential effects of bisphenol A on the ring-legged earwig, Euborellia annulipes, as a model for terrestrial arthropods. Dosages of 0, 0.12, 1.2 and 12 microg bisphenol A were injected over a 6 day period into newly eclosed males and newly mated (7-day) females. The lowest dosage (0.12 microg) was most effective in eliciting significant effects including reducing weight gain while increasing testis size and seminal vesicle size; higher dosages were less effective or ineffective. In females, treatment with 0.12 microg bisphenol A enhanced clutch size but higher dosages were required to affect the duration of embryogenesis in offspring of treated mothers. Hatching success and the onset of the second reproductive cycle were not affected by treatments. No gross abnormalities were observed as a result of treatment in the reproductive structures of either males or females. Similarly, injection of varying concentrations of estradiol into males enhanced testis length, though it had no effect on seminal vesicle size. Lastly, we administered bisphenol A in drinking water for up to 2 weeks. Surprisingly, as little as 1 microg/L inhibited testis growth; 100 microg/L inhibited ovarian growth.

show abstract

Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas

Cited by 86 publications

References 62 publications

A critical analysis of the biological impacts of plasticizers on wildlife

A critical analysis of the biological impacts of plasticizers on wildlife

Multi-marker study of the response of bivalve mollusk Unio tumidus induced by the compounds of typical municipal effluents

Effects of bisphenol A in the ring-legged earwig, Euborellia annulipes

Contact Info

Product

Resources

About