Bisphenol A alters gut microbiome: Comparative metagenomics analysis

Lai, Keng Po; Chung, Yan-Tung; Li, Rong; Wan, Hin-ting; Wong, Chris K C

doi:10.1016/j.envpol.2016.08.039

Cited by 147 publications

(82 citation statements)

References 53 publications

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“…It is known that the administration of this substance causes damage in the intestinal barrier and results in changes in the permeability of the enterocytes, which may lead to allergic reactions. Moreover, BPA can affect the gut microbiota, which is demonstrated, among others, by the reduction of the Firmicutes and Clostridia populations and simultaneous abundance of the Helicobacteraceae family . The influence of these processes on the enteric neurons is even more likely due to the fact that previous studies have clearly reported close interactions between the ENS and enterocyte integrity, allergies and the composition of the gut microbiota …”

Section: Discussionmentioning

confidence: 98%

“…Moreover, BPA can affect the gut microbiota, which is demonstrated, among others, by the reduction of the Firmicutes and Clostridia populations and simultaneous abundance of the Helicobacteraceae family. 47 The influence of these processes on the enteric neurons is even more likely due to the fact that previous studies have clearly reported close interactions between the ENS and enterocyte integrity, allergies and the composition of the gut microbiota. 31 Bisphenol A-induced changes in the enterocytes and gut microbiota may result in the development of inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

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Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Szymańska

Gonkowski

2019

Neurogastroenterology Motil

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Background Bisphenol A (BPA) is commonly used in the production of plastics and has multidirectional, negative effects on the living organisms. It may also affect the enteric nervous system (ENS) located in the wall of the gastrointestinal tract. Enteric neurons express many active substances, which regulate majority of intestinal activities not only in physiological conditions but also under the impact of pathological factors. Methods The influence of various doses of BPA on the ENS of jejunum has been investigated using the double immunofluorescence technique. The commercial antibodies against substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL), vesicular acetylcholine transporter (VAChT), and cocaine‐ and amphetamine‐regulated transcript peptide (CART) were used. Key Results Both doses of BPA studied changed the number of the enteric neurons immunoreactive to SP, VIP, GAL, VAChT, and CART, and the intensity of fluctuations depended on the BPA dose and on the type of the enteric plexus. Bisphenol A causes the increase in the number of neurons immunoreactive to the majority of substances studied. The only exception was VAChT‐positive neurons, the number of which was lower under the impact of BPA in the comparison with physiological conditions. Conclusions & Inferences Even low doses of BPA cause the changes in neurochemical characterization of the enteric neurons in the jejunum. These changes may be the first sign of subclinical BPA intoxication. The mechanisms of observed changes are probably connected with neurotoxic and/or pro‐inflammatory activity of BPA, but their exact mechanisms are not fully explained.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Szymańska

Gonkowski

2019

Neurogastroenterology Motil

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“…Bisphenols may also induce neuroendocrine disruptive effects by targeting the gut-microbiome-brain axis [126; 127; 128; 129; 130]. Recently, we, and others, have shown that BPA exposure can affect the gut microbiome in rodent models, dogs, and zebrafish [131; 132; 133; 134]. Thus, the ability of other bisphenols to induce gut dysbiosis and secondary effects on neurobehavioral responses in animal models should be tested.…”

Section: Overall Conclusionmentioning

confidence: 99%

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Rosenfeld

2017

Frontiers in Neuroendocrinology

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Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.

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“…In a mouse model, mice fed a highfat diet demonstrated dysbiosis characterized by an increase in Proteobacteria and decrease in Firmicutes, similar to that observed in CD. 43) A highfat diet results in the accumulation of secondary bile acids, which in turn can inhibit the growth of the Bacteroidetes and Firmicutes phyla, a common dysbiotic feature found in CD. 44) These varied evidences suggest that the dietary pattern influ ences the composition of the intestinal microbiota; through this Diet as an environmental factor Dietary patterns and nutritional factors are considered im portant environmental factors in the etiology of IBD, and the Western diet has long been suspected of contributing to the development of IBD.…”

Section: Diet and Microbiotamentioning

confidence: 99%

Increasing incidence of inflammatory bowel disease in children and adolescents: significance of environmental factors

et al. 2020

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Inflammatory bowel disease (IBD) is a chronic relapsing im munemediated disease of the intestinal tract. Although its pre valence is reportedly lower in Asia than in Western countries, the rapid increase in the incidence of IBD has drawn attention to its etiology, including genetic susceptibility and environmental factors. Specifically, recent studies concerning dietary treatments and intestinal microbiota suggest that these factors may interact with the immune system, and the imbalance of this relationship may lead to immune dysregulation in IBD. Changes in diet or alterations in the composition of the intes tinal microbiota may be associated with the increasing incidence of IBD in Asia. Here, we aim to review recent studies on the role of diet and intestinal microbiota in IBD pathogenesis and the results of the investigations performed to modulate these factors.

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Bisphenol A alters gut microbiome: Comparative metagenomics analysis

Cited by 147 publications

References 53 publications

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Increasing incidence of inflammatory bowel disease in children and adolescents: significance of environmental factors

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