Bisphenol A and human health: A review of the literature

Rochester, Johanna R.

doi:10.1016/j.reprotox.2013.08.008

Cited by 1,649 publications

(994 citation statements)

References 189 publications

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“…BPA has been also used to coat the inner surface of beverage and food containers, regardless of the fact that it has been recognized as an endocrine-disrupting chemical (EDC) since 1936 (Dodds and Lawson, 1936). Indeed, countless studies in the last two decades have documented BPA-related effects on fertility, genital and behavioral abnormalities, heart disease, diabetes, and obesity (Rochester, 2013). However, in those reports, many different in vitro and in vivo systems have been employed, but almost none utilized stem cells.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells

Yin

Yao

Qin

et al. 2015

Journal of Environmental Sciences

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The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic stem cell (ESC) properties which can be exerted in toxicity assays. In fact, ESCs can differentiate in culture to mimic embryonic development in vivo, or specifically to virtually any kind of somatic cells. Here, we used the toxicant Bisphenol A (BPA), a chemical known as a hazard to infants and children, and showed that our stem cell toxicology system was able to efficiently recapitulate most of the toxic effects of BPA previously detected by in vitro system or animal tests. More precisely, we demonstrated that BPA affected the proper specification of germ layers during our in vitro mimicking of the embryonic development, as well as the establishment of neural ectoderm and neural progenitor cells.

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Section: Introductionmentioning

confidence: 99%

Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells

Yin

Yao

Qin

et al. 2015

Journal of Environmental Sciences

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“…Among the pollutants of 43 particular concern are phenolic substances due to their potential endocrine disrupting 44 properties in organisms like certain invertebrates (Prasain et al, 2012) and mammals (Wu et 45 al., 2011), possibly even at low concentration levels (Rochester, 2013). By interfering with 46 the human hormone system (Takayanagi et al, 2006), they can cause adverse health effects 47 such as infertility (Chen et al, 2013) and birth defects (Philippat et al, 2012).…”

Section: Introduction 40 41mentioning

confidence: 99%

Analysis of phenolic compounds in the dissolved and suspended phases of Lake Balaton water by gas chromatography-tandem mass spectrometry

Faludi

Balogh

Serfözö

et al. 2015

Environ Sci Pollut Res

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“…Some of recent human studies report that bisphenol A may affects humans, but others do not [36]. In the reports indicating the possible association of bisphenol A exposure with human diseases, the attention has been paid to altered behavior in children exposed to the chemical in utero or before puberty, as well as adult obesity, type-2 diabetes, and cardiovascular disorders.…”

Section: Nsmentioning

confidence: 99%

Temporal Effects of Bisphenol A on Dopaminergic Neurons: An Experiment on Adult Rats

Ishido

Masuo

2014

TOENVIRJ

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Abstract:The vulnerability of developing brains to environmental chemicals has been reported. Here, we examined the temporal effects of bisphenol A on dopaminergic neurons. Exposure of 5-day-old rats to bisphenol A caused hyperactivity in juveniles, after which spontaneous motor activity leveled off at 8 weeks of age, when apoptotic cell death was still observed along with the loss of tyrosine hydroxylase immunoreactivity. Accumulation of α-synuclein, a pathological marker of neurodegeneration, was also detectable in the substantia nigra, but not in the cerebral cortex. In adult rats, acute toxicity following microinjection of bisphenol A (20 µg) caused degeneration of dopaminergic neurons, similar to that following administration of 6-hydroxydopamine (15 µg). Chronic exposure of adult rats to bisphenol A (3 mg/kg/day for 28 days) caused neurodegeneration in the substantia nigra. However, behavioral effects were not seen after either acute or chronic exposure of adult rats to bisphenol A.Thus, the sensitivity of the central nervous system to bisphenol A was shown to be different at different life stages, confirming the greater vulnerability of the developing central nervous system.

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Bisphenol A and human health: A review of the literature

Cited by 1,649 publications

References 189 publications

Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells

Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells

Analysis of phenolic compounds in the dissolved and suspended phases of Lake Balaton water by gas chromatography-tandem mass spectrometry

Temporal Effects of Bisphenol A on Dopaminergic Neurons: An Experiment on Adult Rats

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