Bisphenol A (BPA) in the serum of pet dogs following short-term consumption of canned dog food and potential health consequences of exposure to BPA

Koestel, Zoe L.; Backus, Robert C.; Tsuruta, Kaoru; Spollen, William G.; Johnson, Sarah A.; Javurek, Angela B.; Ellersieck, Mark R.; Wiedmeyer, Charles E.; Kannan, Kurunthachalam; Xue, Jingchuan; Bivens, Nathan J.; Givan, Scott A.; Rosenfeld, Cheryl S.

doi:10.1016/j.scitotenv.2016.11.162

Cited by 55 publications

(57 citation statements)

References 58 publications

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“…Among possible factors, increased exposure to endocrine disruptors 1 , such as food contaminants (Koestel et al 2017), toys, or plastic utensils (Wooten & Smith 2013). Such substances interfere with several physiological mechanisms, from the inhibition of hormone synthesis (such as happens with lindane reducing StAR protein expression, decreasing 1 Note: Endocrine disruptors are substances exogenous to the organism that may interfere with synthesis, secretion, transport, metabolism or elimination of different hormones (Sonnenschtein & Soto 2010).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological, clinical, and laboratory aspects in a case series of canine hyperadrenocorticism: 115 cases (2010-2014)

et al. 2019

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Diseases’ clinical-epidemiological characterization assists in directing the diagnosis. The objective of this study was to describe epidemiological, clinical and laboratorial aspects of a case series of canine hyperadrenocorticism (HAC). One-hundred fifteen records of dogs diagnosed by the low dose dexamethasone suppression test and/or ACTH stimulation test were evaluated. Of the cases, 81.3% were HAC ACTH-dependent and 18.7% HAC ACTH-independent. Females were more affected, representing 69.3% of the cases. The mean age was 10.3±2.5 years and 64.9% were gonadectomized. Most of the patients were small size dogs, weighting less than 10kg (73.9%). The most frequent breeds were: Poodle (27%), Dachshund (17.4%), and Yorkshire Terrier (10.4%). The most frequent clinical manifestations were polyphagia (86%), polydipsia (82.6%), polyuria (80%), abdominal enlargement (82.6%), thin skin (79.1%), muscular weakness (78.3%) and panting (74.8%). However, eventually unusual HAC-associated signs would be present in some dogs in a more important way compared with the classic disease´s clinical signs. The CBC showed neutrophilia (66%), eosinopenia (58.3%) and lymphopenia (42.6%) as main hematological abnormalities. The most common findings in serum biochemistry were increased alkaline phosphatase activity (81.74%), increased ALT activity (62.6%), hypercholesterolemia (66%) and hypertriglyceridemia (54.7%). Urinalysis revealed hyposthenuria in 14.9% and isostenuria in 13.5%; besides proteinuria in 50% of the cases. Abdominal ultrasound showed bilateral adrenal hyperplasia (92.2%) with adrenal asymmetry in 20.8% of the cases, in addition to hepatomegaly (80.9%), biliary sludge (67.8%) and hepatic hyperechogenicity (47.8%). It was concluded that small size gonadectomized female dogs, mainly Poodles and Dachshunds, presented higher frequency in the population studied, and that the main changes observed in clinical and complementary tests were polyphagia, polyuria, polydipsia, abdominal enlargement, adrenal hyperplasia, increased phosphatase alkaline and hyperlipidemia. These results corroborated to a better disease characterization at Brazil. This work concluded that the population studied resembles the profile describe in European and North American epidemiologic studies, and that the HAC dog´s clinical picture looks similar worldwide.

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Section: Discussionmentioning

confidence: 99%

Epidemiological, clinical, and laboratory aspects in a case series of canine hyperadrenocorticism: 115 cases (2010-2014)

et al. 2019

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“…Bisphenols may also induce neuroendocrine disruptive effects by targeting the gut-microbiome-brain axis [126; 127; 128; 129; 130]. Recently, we, and others, have shown that BPA exposure can affect the gut microbiome in rodent models, dogs, and zebrafish [131; 132; 133; 134]. Thus, the ability of other bisphenols to induce gut dysbiosis and secondary effects on neurobehavioral responses in animal models should be tested.…”

Section: Overall Conclusionmentioning

confidence: 99%

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Rosenfeld

2017

Frontiers in Neuroendocrinology

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Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.

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“…The work by Koestel et al (2017) [47] showed that the circulating BPA levels in dogs fed with canned dog food for two weeks (2.2 ± 0.15 ng/mL) were similar to the levels found in humans [99], with higher BPA concentrations related to modifications in the composition of the microbiome. These changes may lead to modifications in metabolic pathways, including the capacity to metabolize bisphenols.…”

Section: Bpa Exposure Induced Significant Decrease Inmentioning

confidence: 60%

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

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Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.

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Bisphenol A (BPA) in the serum of pet dogs following short-term consumption of canned dog food and potential health consequences of exposure to BPA

Cited by 55 publications

References 58 publications

Epidemiological, clinical, and laboratory aspects in a case series of canine hyperadrenocorticism: 115 cases (2010-2014)

Epidemiological, clinical, and laboratory aspects in a case series of canine hyperadrenocorticism: 115 cases (2010-2014)

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

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