Bisphenol A Causes Malformation of the Head Region in Embryos of Xenopus laevis and Decreases the Expression of the ESR-1 Gene Mediated by Notch Signaling

Monitoring of Gene Expression in Differentiation of Embryoid Bodies From Cynomolgus Monkey Embryonic Stem Cells in the Presence of Bisphenol A

“…In mice, prenatal and neonatal exposure to BPA induces a significant increase in the levels of dopamine D 1 receptor mRNA in the brain and increases central dopamine D 1 receptor-mediated activity (Suzuki et al, 2003). In addition, expression of PAX-6 mRNA in embryos of Xenopus laevis was reported to be suppressed by treatment with 50 or 100 μM BPA from stage 10.5 to stage 35 (Imaoka et al, 2007). PAX-6 is recognized as a master control gene for the development of eyes, sensory organs and certain neural and epidermal tissues that are usually derived from ectodermal tissues (Kondoh et al, 2004).…”

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

“…Imaoka et al (2007), supported by the Japanese Ministry of Education, Science, Culture, Sports, and Technology, evaluated the effects of bisphenol A on development of the African clawed frog, Xenopus laevis. Embryos were cultured with bisphenol A from Stage 10.5, formation of the neural plate, to Stage 35 at a bisphenol A (in DMSO) concentration of 25, 50, or 100 mM [5.8, 11, or 23 mg/L].…”

Inhibition of the Functional Interplay between Endoplasmic Reticulum (ER) Oxidoreduclin-1α (Ero1α) and Protein-disulfide Isomerase (PDI) by the Endocrine Disruptor Bisphenol A

“…1 A ) and accumulates in tissues once taken up by living organisms. In addition to its antagonist/agonist effects on steroid hormone receptors, BPA induces a number of detrimental effects on the central nervous system, including induction of abnormal behavior in mice and morphogenic malformation in Xenopus laevis (4). Several lines of evidence demonstrate that BPA exposure causes adverse effects on human health (5).…”