Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit

Thent, Zar Chi; Froemming, Gabriele Ruth Anisah; Muid, Suhaila Abd

doi:10.1016/j.lfs.2018.02.013

Cited by 46 publications

(26 citation statements)

References 83 publications

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“…This corroborated the previous data showing that increased oxidative stress damages several tissues including the bone tissue [97]. More recently, a study showed that a 12.5 μM dose of BPA reduces differentiation and increases the apoptosis in osteoblasts and osteoclasts [83]. BPA exerts estrogen antagonistic effect on bone cells by binding to the non-classical ER γ receptor, which reduces the activity of bone specific markers such as BMP-2 and ALP.…”

Section: Osteogenic Differentiationsupporting

confidence: 90%

“…When considering other studies related to differentiation of MSCs, there is limited information about the toxic effect of BPA towards bone health [83]. It is known that BPA may affect adult bone metabolism and its disorders, including osteoporosis through the SXR signaling in both adult and fetal bones [84].…”

Section: Osteogenic Differentiationmentioning

confidence: 99%

“…Recent studies demonstrated that BPA disturbs the bone metabolism via the RANKL (Receptor activator of nuclear factor kappa-Β ligand) pathway, apoptotic pathway, and the Wnt/β-catenin signaling pathway. However, the exact underlying mechanism has not yet been unraveled [83].…”

Section: Osteogenic Differentiationmentioning

confidence: 99%

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Bisphenol a and mesenchymal stem cells: Recent insights

et al. 2018

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Mesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human and animal sources. These cells are important in regenerative medicine and cell therapy, thus adipose tissue is a rich and promising source of these cells. Adipose-derived stem cells (ASCs) are often effective and safe, and have been used in preclinical and clinical studies for both autologous and allogeneic transplantation. The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs provides an important alternative therapeutic solution for the treatment of many diseases. However, it is necessary to have control of the cell manipulation process prior to their use. Exposure of humans to the endocrine disruptor bisphenol A (BPA) has been associated with increased weight and obesity, but the mechanisms by which BPA increases adipose tissue in humans remains to be determined. BPA has been classified as a potent endocrine-disrupting chemical that interferes with adipogenesis. Currently, few studies have reported the effect of BPA on the integrity and capacity for differentiation of MSCs. Thus, this review aims to present, for the first time, a current survey and a discussion of the effects of BPA action on MSCs.

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Section: Osteogenic Differentiationsupporting

confidence: 90%

Section: Osteogenic Differentiationmentioning

confidence: 99%

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Bisphenol a and mesenchymal stem cells: Recent insights

et al. 2018

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“…A decrease in BMP2 production through a direct binding of BPA to ERγ was involved in bone loss through a suppression of osteoblast differentiation reverted by inhibition of ERγ [146]. This suggests that the effects and mechanisms of BPA-induced BMP ligand production depend on the estrogen receptor expression profile and are context dependent [147]. However, the molecular mechanism by which BPA induces BMP2 production by stromal cells of the mammary gland BMP2 is not yet known.…”

Section: Bmp and Bisphenolsmentioning

confidence: 99%

A Potential New Mechanism for Bisphenol Molecules to Initiate Breast Cancer through Alteration of Bone Morphogenetic Protein Signaling in Stem Cells and Their Microenvironment

Guyot¹,

Maguer-Satta²

2020

Breast Cancer Biology

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Endocrine disruptors interfere with endocrine-mediated regulations of cell or organ functions. Estrogens are one of the main hormones altered by endocrine disruptors like bisphenol A (BPA). Stem cells are active from embryogenesis to late stages of adult life. Their unique properties, such as an extended lifespan and low cycling features, render these cell privileged targets of long-term exposure to numerous factors. Therefore, stem cells are likely to be affected following exposure to endocrine disruptors. One of the major signaling pathways involved in stem cell regulation is the bone morphogenetic protein (BMP) pathway. The BMP pathway is known for its involvement in numerous physiological and pathophysiological processes. Exposure of human mammary stem cells to pollutants such as BPA initiates fundamental changes in stem cells, in particular by altering major elements of BMP signaling, such as receptor expression and localization. Lastly, BPA and its substitute bisphenol S (BPS) have similar impacts on BMP signaling despite their different ER-binding properties, supporting the hypothesis that their biological effects cannot be extrapolated only from their interaction with ERα66. We review recent discoveries in this field and discuss their implications for cancer diagnosis, prevention, and treatment, as well as their relevance for studies on endocrine disruptors.

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“…Recently, studies reported that BPA believed to disturb bone metabolism. BPA exerts estrogen antagonistic effect on bone cells by binding to the non-classical ERγ receptor which reduces the differentiation and increases the apoptosis in the osteoblasts and osteoclasts 32 .…”

mentioning

confidence: 99%

Untitled

2019

IJPSR

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Bisphenol-A (BPA), 2,2-bis(4-hydroxyphenyl) propane is an emerging environmental toxicant with endocrine disrupting properties and toxic effects on living organisms. BPA is ubiquitously present in consumer products current in our daily lives. As it is released from consumer products and deposited in the environment, thus creating the potential for human exposure through oral, inhaled, and dermal routes. BPA exposure might be able to cause oxidative damage by disturbing the balance between reactive oxygen species (ROS) and the antioxidant defense system of eukaryotic cells, resulting in the development of oxidative stress-related diseases. From the available information, it can be inferred that a wide variety of BPA intake through any mode results into a generation of reactive oxygen species (ROS), altering the antioxidant balance of eukaryotic cells, induces mitochondrial dysfunction, and affects cell signaling pathways related to oxidative stress. BPA induced oxidative stress might be able to cause sperm damage, mitochondrial dysfunction, and impairment of the structure and function of spermatozoa resulting in male infertility. Here, a review of the current literature examining literature related to BPA exposure, induction of ROS or oxidative stress and concludes that it alters reproductive system functions through induced oxidative stress pathways and negatively affects the fertility of male and females.

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Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit

Cited by 46 publications

References 83 publications

Bisphenol a and mesenchymal stem cells: Recent insights

Bisphenol a and mesenchymal stem cells: Recent insights

A Potential New Mechanism for Bisphenol Molecules to Initiate Breast Cancer through Alteration of Bone Morphogenetic Protein Signaling in Stem Cells and Their Microenvironment

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