Bisphenol A exposure during the embryonic period: Insights into dopamine relationship and behavioral disorders in Drosophila melanogaster

Musachio, Elize Aparecida Santos; Couto, Shanda de Freitas; Poetini, Márcia Rósula; Bortolotto, Vandreza Cardoso; Dahleh, Mustafa Munir Mustafa; Janner, Dieniffer Espinosa; Araújo, Stífani Machado; Ramborger, Bruna Piaia; Rohers, Rafael; Guerra, Gustavo Petri; Prigol, Marina

doi:10.1016/j.fct.2021.112526

Cited by 17 publications

(6 citation statements)

References 55 publications

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“…It has been suggested to be a susceptible window to many hazardous exposures in previous studies. 65 , 66 These associations were also significant among women without pregnancy complications. Consistent with our findings, a recent animal study in rats also showed significantly increased maternal circulating sFlt-1 associated with

exposures in both early and late gestation.…”

Section: Discussionmentioning

confidence: 77%

Longitudinal Associations between Ambient Air Pollution and Angiogenic Biomarkers among Pregnant Women in the LIFECODES Study, 2006–2008

Zheng,

McElrath,

Cantonwine

et al. 2023

Environ Health Perspect

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Background: Exposures to ambient air pollution during pregnancy have been linked to adverse pregnancy outcomes such as preeclampsia and fetal growth restriction. Although evidence has shown that women with preeclampsia have higher ratio of soluble fms-like tyrosine kinase 1 to placental growth factor (sFlt-1/PlGF ratio), the potential impact of air pollution on markers of placental growth and function has not been well studied. Objectives: We aimed to examine longitudinal associations between ambient air pollution exposure and angiogenic factors among pregnant women in LIFECODES, a prospective birth cohort and biorepository in Massachusetts in the United States. Methods: PlGF and sFlt-1 were measured among pregnant women using plasma samples collected around 10, 18, 26, and 35 wk’ gestation. Women’s exposures to ozone ( ), fine particulate matter with aerodynamic diameter ( ), and nitrogen dioxide ( ) within 1, 2, 4, and 8 wk prior to each plasma sample collection were estimated based on geocoded residential addresses, and mixed effect linear regression models were fitted to assess their associations with sFlt-1/PlGF ratio, sFlt-1 (ng/mL), and PlGF (pg/mL). Percent changes in outcomes associated with each interquartile range increase in exposures were reported, along with their 95% confidence intervals. Results: A total of 1,066 pregnant women were included. In the multipollutant models, significant associations were observed for increased sFlt-1/PlGF ratio ( 3–8 wk’ gestation, : 35–39 wk’ gestation), elevated sFlt-1 ( : 26–34 wk’ gestation, : 3–8 wk’ gestation), decreased sFlt-1 ( : 4–8 wk’ gestation), and decreased PlGF ( : 34–39 wk’ gestation) after adjusting for sociodemographic status, smoking, drinking, body mass index, parity, history of chronic hypertension, and conception time. Discussion: Exposures to during early pregnancy and exposures to and during late pregnancy were associated with increased sFlt-1/PlGF ratio, elevated sFlt-1 and with decreased PlGF, which may be a potential mechanism underlying ambient air pollution’s impacts on adverse pregnancy and birth outcomes. https://doi.org/10.1289/EHP11909

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exposures in both early and late gestation.…”

Section: Discussionmentioning

confidence: 77%

Longitudinal Associations between Ambient Air Pollution and Angiogenic Biomarkers among Pregnant Women in the LIFECODES Study, 2006–2008

Zheng,

McElrath,

Cantonwine

et al. 2023

Environ Health Perspect

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“…The LC 50 (lethal concentration for 50% of the population) was determined following the protocol established by Musachio et al [ 12 ]. For this purpose, second-stage larvae of D. melanogaster were placed in Petri dishes under various conditions: (1) a control group (standard diet only) and groups with different concentrations of camu-camu mixed with the standard diet, including (2) 0.1 mg/mL, (3) 0.5 mg/mL, (4) 1 mg/mL, (5) 5 mg/mL, (6) 10 mg/mL, and (7) 50 mg/mL.…”

Section: Methodsmentioning

confidence: 99%

The Amazonian Camu-Camu Fruit Modulates the Development of Drosophila melanogaster and the Neural Function of Adult Flies under Oxidative Stress Conditions

Musachio,

Pires,

Fernandes

et al. 2024

Antioxidants

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Camu-camu (Myrciaria dubia) is known for its antioxidant properties, although little is known about its developmental safety effects, particularly on adult neural function under basal redox and oxidative stress conditions. Therefore, this study sought to address this gap by conducting three complementary protocols using Drosophila melanogaster to investigate these effects. The initial assays revealed that second-stage larvae consumed diets supplemented with various concentrations of camu-camu uniformly, establishing a 50% lethal concentration at 4.799 mg/mL. Hence, non-lethal (0.1, 0.5, and 1 mg/mL) and sub-lethal (5 and 10 mg/mL) concentrations were then chosen to evaluate the effects of camu-camu on preimaginal development and adult neural function. Our observations showed that camu-camu impacts the expression of antioxidant enzymes, reactive species, and lipoperoxidation. Notably, sub-lethal concentrations decreased preimaginal viability and locomotor activity, negatively influenced geotaxis and acetylcholinesterase activity, and increased reactive species, catalase, and glutathione S-transferase activity in flies. Additionally, the protective effects of camu-camu against oxidative stress induced by iron (20 mM) were assessed. Flies supplemented with 0.5 mg/mL of camu-camu during the larval period showed improved neural viability and function, and this supplementation was found to protect against oxidative stress. These findings are instrumental in evaluating the safety and efficacy of commercial supplements based on camu-camu, offering significant insights for future research and application.

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“…Interestingly, exposure to β-estradiol (0.1 μM) also led to larval hyperactivity. In a recent paper, it was demonstrated that treating D. melanogaster embryos with BPA (1 mM) induced pathological developmental changes in behavior, such as incompatibility in social interactions and hyperactivity, which manifest as an enhancement of locomotion in open field tests and aggression episodes ( Musachio et al, 2021 ).…”

Section: Phenols and Neuropsychiatric Disordersmentioning

confidence: 99%

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Menzikov,

Zaichenko,

Moskovtsev

et al. 2024

Front. Pharmacol.

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γ-Aminobutyric acid type A receptors (GABAARs) are members of the pentameric ligand-gated ion channel (pLGIC) family, which are widespread throughout the invertebrate and vertebrate central nervous system. GABAARs are engaged in short-term changes of the neuronal concentrations of chloride (Cl−) and bicarbonate (HCO3−) ions by their passive permeability through the ion channel pore. GABAARs are regulated by various structurally diverse phenolic substances ranging from simple phenols to complex polyphenols. The wide chemical and structural variability of phenols suggest similar and different binding sites on GABAARs, allowing them to manifest themselves as activators, inhibitors, or allosteric ligands of GABAAR function. Interest in phenols is associated with their great potential for GABAAR modulation, but also with their subsequent negative or positive role in neurological and psychiatric disorders. This review focuses on the GABAergic deficit hypotheses during neurological and psychiatric disorders induced by various phenols. We summarize the structure–activity relationship of general phenol groups concerning their differential roles in the manifestation of neuropsychiatric symptoms. We describe and analyze the role of GABAAR subunits in manifesting various neuropathologies and the molecular mechanisms underlying their modulation by phenols. Finally, we discuss how phenol drugs can modulate GABAAR activity via desensitization and resensitization. We also demonstrate a novel pharmacological approach to treat neuropsychiatric disorders via regulation of receptor phosphorylation/dephosphorylation.

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Bisphenol A exposure during the embryonic period: Insights into dopamine relationship and behavioral disorders in Drosophila melanogaster

Cited by 17 publications

References 55 publications

Longitudinal Associations between Ambient Air Pollution and Angiogenic Biomarkers among Pregnant Women in the LIFECODES Study, 2006–2008

Longitudinal Associations between Ambient Air Pollution and Angiogenic Biomarkers among Pregnant Women in the LIFECODES Study, 2006–2008

The Amazonian Camu-Camu Fruit Modulates the Development of Drosophila melanogaster and the Neural Function of Adult Flies under Oxidative Stress Conditions

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

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