Bisphenol a exposure in Mexico City and risk of prematurity: a pilot nested case control study

Cantonwine, David E.; Meeker, John D.; Hu, Howard; Sánchez, Brisa N.; Lamadrid‐Figueroa, Héctor; Mercado‐García, Adriana; Fortenberry, Gamola Z.; Calafat, Antònia M.; Téllez‐Rojo, Martha María

doi:10.1186/1476-069x-9-62

Cited by 164 publications

(105 citation statements)

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“…1 The use of BPA-containing products in daily life makes exposure ubiquitous in industrialized and industrializing countries. [2][3][4][5] The predominant source of BPA exposure for most people is diet, although exposure also might occur through inhalation or dermal absorption, which results in substantial exposure among persons involved in the manufacture or handling of BPAcontaining products. [6][7][8][9][10] BPA might disrupt the endocrine system.…”

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confidence: 99%

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

et al. 2011

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WHAT'S KNOWN ON THIS SUBJECT:Virtually all persons in industrialized countries are exposed to bisphenol A (BPA), and early-life BPA exposure might be associated with behavior problems. Few human studies have been conducted, and the impact of gestational versus childhood BPA exposures is unclear. WHAT THIS STUDY ADDS:BPA exposure during pregnancy, but not childhood, was associated with worse behavior at 3 years of age, especially among girls. Domains related to behavioral and emotional regulation were most affected by gestational BPA exposure. abstract OBJECTIVES:To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations. METHODS:We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). RESULTS:BPA was detected in Ͼ97% of the gestational (median: 2.0 g/L) and childhood (median: 4.1 g/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender. CONCLUSIONS:In this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear. Pediatrics 2011;128:873-882 AUTHORS:

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Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

et al. 2011

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“…2 BPA shows affinity for the estrogen receptor and may alter its function by blocking or mimicking the action of estrogen. 3 Previous epidemiological studies have reported the associations between BPA exposure and adverse health effects on the reproductive [4][5][6][7][8] and endocrine systems. 9 BPA exposure had also been associated with cardiovascular disorders.…”

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Exposure to Bisphenol A From Drinking Canned Beverages Increases Blood Pressure

2015

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Bisphenol A (BPA) is a chemical used in the production of polycarbonate plastic and epoxy resins, which are used in a wide range of products, including plastic bottles, food containers, optical discs, dental fillings, and on the inner coating of cans.1 Therefore, BPA exposure is ubiquitous and has been detected in >95% of the population in the United States. 2BPA shows affinity for the estrogen receptor and may alter its function by blocking or mimicking the action of estrogen. 3Previous epidemiological studies have reported the associations between BPA exposure and adverse health effects on the reproductive 4-8 and endocrine systems. 9 BPA exposure had also been associated with cardiovascular disorders. We had previously reported that increased urinary BPA concentration was associated with higher blood pressure (BP) and decreased heart rate variability (HRV) in a panel study with elderly participants. 10 A previous study that analyzed the National Health and Nutrition Examination Survey data set also reported that increased urinary BPA concentration was associated with hypertension.11 Furthermore, other studies had reported that increased urinary BPA was associated with heart and peripheral artery diseases, of which hypertension and decreased HRV are important risk factors. 9,[12][13][14] Considering that most of the previous epidemiological studies examined the crosssectional associations between urinary BPA concentration and health outcomes, a randomized intervention trial can provide a higher level of evidence and may elucidate the health effect of BPA more clearly.Canned food is one of the known BPA exposure sources. Previous studies have reported that BPA in the epoxy lining of the can containers could leach into food.15-17 A randomized crossover trial showed that eating canned soup for 5 consecutive days increased urinary BPA concentration by >1000% compared with eating soup cooked with fresh ingredients. 18The increase exceeds the range of exposure previously reported to be associated with increased risk of cardiovascular disorders in the previous epidemiological studies. However, we could not find any report on the health effect of such increased exposure caused by consuming canned food.In the present study, we conducted randomized crossover intervention trial to examine whether consuming canned beverage and consequent increase of BPA exposure actually affect BP and HRV.Abstract-Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. BPA has been associated with hypertension and decreased heart rate variability in the previous studies. The aim of the present study was to determine whether increased BPA exposure from consumption of canned beverage actually affects blood pressure and heart rate variability. We conducted a randomized crossover trial with noninstitutionalized adults, who were aged ≥60 years and recruited from a local community center. A total of 60 participants visited the study site 3 times, and they were provided t...

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“…[4][5][6] Epidemiological studies have suggested that BPA could have adverse effects on human health. 7 Specifically, BPA exposure has been shown to be associated with increased production of liver enzymes, 8 recurrent miscarriages, 9 premature delivery of fetuses, 10 inflammation and oxidative stress, 11 decreased quality of semen, 12,13 and male sexual dysfunction. 14 In 2008, Lang et al 8 conducted a study investigating the associations between past history of chronic diseases and BPA concentration by analyzing data sets from the National Health and Nutrition Examinations Survey.…”

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Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure

et al. 2012

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Abstract-Bisphenol A (BPA) is a high-volume production chemical that has been suspected to have adverse health effects.Recent studies have suggested that cardiovascular diseases are associated with the BPA exposure. The aim of present study was to investigate the associations of urinary BPA with heart rate variability and blood pressure. We recruited 560 noninstitutionalized elderly citizens from August 2008 to August 2010 in Seoul. All of the participants were Ն60 years old. The participants took medical examinations Յ5 times. Urinary BPA concentration, heart rate variability, and blood pressure were measured at each time. A total of 1511 observations from 521 participants were included in the analyses. We observed that urinary BPA was associated negatively with the root mean square of successive differences for heart rate and positively with blood pressure. BPA is considered to be an endocrine-disrupting chemical, and it shows affinity for estrogen receptors. It was initially considered to be a weak xenoestrogen, but subsequent studies showed that BPA can have effects even at low concentrations.3 In addition, pathways other than binding to estrogen receptors have been proposed. These include the thyroid hormone pathway, binding to glucocorticoid receptors and androgen receptors, or interfering with the central nervous system and immune system. [4][5][6] Epidemiological studies have suggested that BPA could have adverse effects on human health.7 Specifically, BPA exposure has been shown to be associated with increased production of liver enzymes, 8 recurrent miscarriages, 9 premature delivery of fetuses, 10 inflammation and oxidative stress, 11 decreased quality of semen, 12,13 and male sexual dysfunction. 14 In 2008, Lang et al 8 conducted a study investigating the associations between past history of chronic diseases and BPA concentration by analyzing data sets from the National Health and Nutrition Examinations Survey. They reported that the concentration of urinary BPA was associated with history of diabetes mellitus and cardiovascular diseases (CVDs).8 Later, Melzer et al 15 conducted similar analyses using larger National Health and Nutrition Examinations Survey data sets and found association between the concentration of BPA and CVDs but not with diabetes mellitus. More recently, a nested case-control study reported the association between higher BPA exposure and incident coronary artery disease with a dose-response relationship. 16 However, the knowledge on how BPA affects the cardiovascular system is still limited.The cells of the cardiovascular system have estrogen receptors (␣ and ␤). These receptors are involved in antiatherogenic actions, vasodilation and preservation of vascular integrity, cardiomyocyte survival, and regulation of excitability of smooth muscle cells. 17,18 As a xenoestrogen, BPA may alter these functions of estrogen receptors by mimicking or blocking the action of estrogen. 19 We hypothesized that exposure to BPA is associated with reduced heart rate variability (HRV) and hyperten...

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Bisphenol a exposure in Mexico City and risk of prematurity: a pilot nested case control study

Cited by 164 publications

References 50 publications

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

Exposure to Bisphenol A From Drinking Canned Beverages Increases Blood Pressure

Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure

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