2022
DOI: 10.3390/molecules27072274
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Bisphenol A Impairs Lipid Remodeling Accompanying Cell Differentiation in the Oligodendroglial Cell Line Oli-Neu

Abstract: In the central nervous system, the process of myelination involves oligodendrocytes that wrap myelin around axons. Myelin sheaths are mainly composed of lipids and ensure efficient conduction of action potentials. Oligodendrocyte differentiation is an essential preliminary step to myelination which, in turn, is a key event of neurodevelopment. Bisphenol A (BPA), a ubiquitous endocrine disruptor, is suspected to disrupt this developmental process and may, thus, contribute to several neurodevelopmental disorders… Show more

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Cited by 4 publications
(4 citation statements)
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“…7A). Cell differentiation was induced by adding PD174265, a selective inhibitor of the EGF receptor that has been previously shown to be a differentiating agent for Oli-neu cells, and was confirmed by increased levels of Mog and decreased expression levels of Pdgfrα (Naffaa et al , 2022) (Fig. 7B).…”
Section: Resultsmentioning
confidence: 64%
See 1 more Smart Citation
“…7A). Cell differentiation was induced by adding PD174265, a selective inhibitor of the EGF receptor that has been previously shown to be a differentiating agent for Oli-neu cells, and was confirmed by increased levels of Mog and decreased expression levels of Pdgfrα (Naffaa et al , 2022) (Fig. 7B).…”
Section: Resultsmentioning
confidence: 64%
“…Lentiviruses expressing full-length human AR containing 17 or 97 CAG repeats were introduced into Oli-neu cells, thereby generating cell lines harboring AR-17Q as control cells and cell lines harboring AR-97Q as SBMA model cells. Differentiation was induced by adding 1 μM PD174265 (Calbiochem, CA, USA) to the medium for 72 hours (Naffaa et al , 2022).…”
Section: Methodsmentioning
confidence: 99%
“…Conversely, in oligodendroglial cell lines (oli-neu), was examined how BPA affected their differentiation. BPA incubation decreased the amount of sulfatide and phosphatidylinositol in plasmalogen and changed the ratio of monounsaturated/polyunsaturated fatty acids in phospholipids, suggesting that BPA interferes with early oligodendrocyte differentiation’s lipid remodelling process (Naffaa et al 2022 ). Furthermore, by treating PC12 cells, which is a cell line derived from a pheochromocytoma of the rat adrenal medulla, with BPA at 1 μM for 36 h, Bi et al proved that exposure to this concentration of BPA impaired the neurite growth by decreasing primary and secondary branches.…”
Section: Effects Of Bpa On Animal Modelsmentioning
confidence: 99%
“…Recent advances in the neuroscience offer the possibility to reduce the number of animals in basic research by conducting in vitro experiments on brain organoids (Chesnut et al 2021 ), neurons and glial cells generated from human induced pluripotent stem cells (Chamling et al 2021 ; Tukker et al 2016 , 2020 ; Wang et al 2013 ; You et al 2022 ) or mesenchymal stem cells derived from the umbilical cord (Sypecka et al 2017 ; Sypecka and Sarnowska 2015 ). Oligodendrocyte lineage cells can be also differentiated directly from neural stem cells derived from brains of rodents of different age (Baldassarro et al 2020 ; Li et al 2019 ; Samper Agrelo et al 2020 ), human aborted fetuses (Lu et al 2015 ; Wang et al 2018 ; Ye et al 2022 ) as well as from adults (Marei et al 2018 ) Another useful models are immortalized cell lines, for example, growth factor-dependent cell line of rat oligodendrocyte progenitors—CG4 (Tontsch et al 1994 ), non-immortalized rat oligodendrocyte precursor line—OL-1 (Lagarde et al 2007 ) or immortalized mouse OPCs—Oli-neu (Naffaa et al 2022 ).…”
Section: Introductionmentioning
confidence: 99%