Bisphenol A in Africa: A review of environmental and biological levels

Rotimi, Oluwakemi A.; Olawole, Tolulope Dorcas; Campos, Opeyemi Christianah De; Adelani, Isaacson B.; Rotimi, Solomon O.

doi:10.1016/j.scitotenv.2020.142854

Cited by 64 publications

(23 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extensive use of BPA in various industries has resulted in environmental pollution: BPA has reportedly been found in rivers, lakes, soils, sediments, home dust, and air [ 14 , 15 , 16 , 17 , 18 ]. The most alarming concern is that BPA has also been detected in human biological samples, such as in the blood, urine, sweat, breast milk, and in the umbilical cord [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review

et al. 2021

View full text Add to dashboard Cite

BPA is identified as an endocrine-disrupting chemical that deteriorates the physiological function of the hormones of the male reproductive system. Bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) are actively explored as substitutes for BPA and are known as BPA analogues in most manufacturing industries. These analogues may demonstrate the same adverse effects as BPA on the male reproductive system; however, toxicological data explaining the male reproductive hormones’ physiological functions are still limited. Hence, this mini-review discusses the effects of BPA and its analogues on the physiological functions of hormones in the male reproductive system, focusing on the hypothalamus-pituitary-gonad (HPG) axis, steroidogenesis, and spermatogenesis outcomes. The BPA analogues mainly show a similar negative effect on the hormones’ physiological functions, proven by alterations in the HPG axis and steroidogenesis via activation of the aromatase activity and reduction of spermatogenesis outcomes when compared to BPA in in vitro and in vivo studies. Human biomonitoring studies also provide significant adverse effects on the physiological functions of hormones in the male reproductive system. In conclusion, BPA and its analogues deteriorate the physiological functions of hormones in the male reproductive system as per in vitro, in vivo, and human biomonitoring studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It has become increasingly clear that BPA can bioaccumulate in the food chain. In fact, in a study in Africa, BPA reached very high concentrations in food (940 ng/g), biological fluids (209 ng/mL), consumer and PCPs (3.6 μg/g), and semisolids (154 μg/g) [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival

Lukashina¹,

Williams

Kartysheva

et al. 2021

IJMS

View full text Add to dashboard Cite

Bisphenols are important environmental pollutants that are extensively studied due to different detrimental effects, while the molecular mechanisms behind these effects are less well understood. Like other environmental pollutants, bisphenols are being tested in various experimental models, creating large expression datasets found in open access storage. The meta-analysis of such datasets is, however, very complicated for various reasons. Here, we developed an integrating statistical and machine-learning model approach for the meta-analysis of bisphenol A (BPA) exposure datasets from different mouse tissues. We constructed three joint datasets following three different strategies for dataset integration: in particular, using all common genes from the datasets, uncorrelated, and not co-expressed genes, respectively. By applying machine learning methods to these datasets, we identified genes whose expression was significantly affected in all of the BPA microanalysis data tested; those involved in the regulation of cell survival include: Tnfr2, Hgf-Met, Agtr1a, Bdkrb2; signaling through Mapk8 (Jnk1)); DNA repair (Hgf-Met, Mgmt); apoptosis (Tmbim6, Bcl2, Apaf1); and cellular junctions (F11r, Cldnd1, Ctnd1 and Yes1). Our results highlight the benefit of combining existing datasets for the integrated analysis of a specific topic when individual datasets are limited in size.

show abstract

“…Consumers worldwide are most familiar with BPA [2], an endocrine-disrupting chemical (EDC) that alters homeostatic, hormonal and several biological systems [22,23]. Studies show that EDCs may be associated with disease and health problems [24] by interfering with hormonal actions, homeostasis, reproduction, and developmental processes [25,26]. Changes in the endocrine system can cause disease, undermine health, and even lead to death [15,27].…”

Section: Introductionmentioning

confidence: 99%

Assessing Knowledge and Use Practices of Plastic Food Packaging among Young Adults in South Africa: Concerns about Chemicals and Health

Preez

Merwe

Wyma

et al. 2021

IJERPH

View full text Add to dashboard Cite

Chemicals associated with health problems can migrate from packaging into food matrices. Therefore, consumers need to be aware of health concerns associated with incorrectly used plastic food packaging. However, little is known about consumers’ knowledge and their plastics usage practices. This study assessed this knowledge and practices among young South African adult consumers. Our online survey of 293 participants focused on their objective (actual) and subjective (self-perceived) knowledge about plastic food packaging care and safety, their utilization practices, and their sources of information about safe use of plastics. Participants’ utilization practices showed broad misuse. Their subjective knowledge about the correct use of plastic packaging was in most respects contradicted by their limited objective knowledge. We found that plastic identification codes on packaging largely failed in their informative purpose; instead, participants mainly consulted informal information sources about plastics. The knowledge gaps, unsafe plastic use practices, and information source deficiencies identified here can help to guide future improvements. We call for consumer education, across all demographics, about plastic utilization practices and associated health concerns about plastic chemicals. We also highlight the need for the government, food and plastics industries to join forces in ensuring that consumers are informed about safe plastic packaging usage.

show abstract

Bisphenol A in Africa: A review of environmental and biological levels

Cited by 64 publications

References 147 publications

Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review

Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review

Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival

Assessing Knowledge and Use Practices of Plastic Food Packaging among Young Adults in South Africa: Concerns about Chemicals and Health

Contact Info

Product

Resources

About