Bisphenol A in combination with TNF-α selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity

Guo, Hongchuan; Liu, Tianyi; Uemura, Yukari; Jiao, Shunchang; Wang, Deqing; Lin, Zilin; Narita, Yayoi; Suzuki, Motoharu; Hirosawa, Narumi; Ichihara, Yasuko; Ishihara, Osamu; Kikuchi, Hirosato; Sakamoto, Yasushi; Senju, Satoru; Zhang, Qiuhang; Ling, Feng

doi:10.1038/cmi.2010.14

Cited by 46 publications

(39 citation statements)

References 49 publications

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“…Using murine as well as human DC differentiation cultures we could also observe diminished IL-12 levels in the presence of BPA. This was similar to findings by Guo et al ., who demonstrated that BPA-exposed DC produced higher levels of IL-10 relative to that of IL-12 and preferentially induced Th2 deviation [16]. However, based on this assumption exposure of the adult mice during antigen sensitization should also enhance the allergic immune response.…”

Section: Discussionmentioning

confidence: 99%

“…The studies mainly describe an interference with hormone receptors like the estrogen receptor. However, these data are also inconsistent and show contrasting results [16], [17]. The inconsistency in the findings might arise due to different observation periods in human studies and the diverging design of the animal models, including the use of varying BPA doses and the route of exposure [18].…”

Section: Introductionmentioning

confidence: 99%

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Lifetime-Dependent Effects of Bisphenol A on Asthma Development in an Experimental Mouse Model

et al. 2014

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BackgroundEnvironmental factors are thought to contribute significantly to the increase of asthma prevalence in the last two decades. Bisphenol A (BPA) is a xenoestrogen commonly used in consumer products and the plastic industry. There is evidence and an ongoing discussion that endocrine disruptors like BPA may affect human health and also exert alterations on in the immune system. The aim of this study was to investigate age-dependent effects of BPA on the asthma risk using a murine model to explain the controversial results reported till date.MethodsBALB/c mice were exposed to BPA via the drinking water for different time periods including pregnancy and breastfeeding. To induce an asthma phenotype, mice were sensitized to ovalbumin (OVA), followed by an intrapulmonary allergen challenge.ResultsBPA exposure during pregnancy and breastfeeding had no significant effect on asthma development in the offspring. In contrast, lifelong exposure from birth until the last antigen challenge clearly increased eosinophilic inflammation in the lung, airway hyperreactivity and antigen-specific serum IgE levels in OVA-sensitized adult mice compared to mice without BPA exposure. Surprisingly, BPA intake during the sensitization period significantly reduced the development of allergic asthma. This effect was reversed in the presence of a glucocorticoid receptor antagonist.ConclusionsOur results demonstrate that the impact of BPA on asthma risk is strongly age-dependent and ranges from asthma-promoting to asthma-reducing effects. This could explain the diversity of results from previous studies regarding the observed health impact of BPA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lifetime-Dependent Effects of Bisphenol A on Asthma Development in an Experimental Mouse Model

et al. 2014

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“…Integrating the totality of the data is challenging, but when one attempts to do so, the picture that forms is one in which exposure to BPA at or below 50 μg/kg/d generally has little effect on adaptive immune responses, but consistently modulates some aspects of inflammation. Altered responses of cells from BPA treated animals, such as elevated T-helper (T H )-2 cell cytokine production, enhanced ex vivo lymphocyte proliferation have been reported (Gallo et al, 2008; Guo et al, 2010); however, when these endpoints were examined in studies that used multiple doses of BPA, exposures in the mg/kg/d range generally altered these endpoints, whereas doses in the μg/kg/d range were rarely shown to affect metrics of lymphocyte function or alter disease progression (Lee et al, 2003; Sawai et al, 2003; Goto et al, 2007). …”

Section: Discussionmentioning

confidence: 99%

“…Indeed, BPA is generally classified as an endocrine-disrupting chemical (EDC), and in recent years there has been much discussion both in the scientific community and in general public regarding the possible adverse health effects of exposure to EDC agents. Third, estrogens and other hormones control many aspects of immune and inflammatory responses (Bebo et al, 2001; Gallo et al, 2008; Guo et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

Neither direct nor developmental exposure to bisphenol A alters the severity of experimental inflammatory colitis in mice

Roy

Gaylo

Cao³

et al. 2013

Journal of Immunotoxicology

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Bisphenol A (BPA) is a high production volume endocrine disrupting chemical that is widely used in many consumer products and prevalent in human biological fluids. Recent studies suggest that BPA is active even at low levels, raising concern about its potential harm to human health. Given that the main route of exposure to BPA is oral, via the consumption of BPA-tainted foods and beverages, intestinal tissues could be particularly vulnerable to BPA induced changes. We report here a novel examination of whether oral exposure to BPA affects inflammatory bowel disease (IBD), an immune mediated disease of the colon, using a mouse model of inflammatory colitis. In addition to direct exposure, we explored the possible contribution of maternal BPA exposure to disease later in life. We found that daily oral exposure to BPA at the US Environmental Protection Agency described oral reference dose (50 μg/kg/d), either via direct oral route or through maternal sources (i.e., developmental exposure), did not significantly alter disease outcomes of body weight, survival, or colonic pathology. These observations suggest that oral BPA exposure, at this dose and for this exposure duration, has minimal influence on aspects of the inflammatory response that regulate immune mediated diseases of the gastrointestinal tract.

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“…BPA induced complex effects on the immune response mainly suppressing antigen-specific cytokine production of T cells. Guo et al (2010) have performed in vitro experiments studying the effect of human monocyte-derived dendritic cells (DC) exposed to BPA on the cytokine production and expression of ER-α, ER-β and GPR30 in naïve human Th cells. This study demonstrated that the presence of BPA during DC maturation influences the function of human DCs, thereby polarizing the subsequent Th response.…”

Section: Effects On Signal Transfer and Gene Expressionmentioning

confidence: 99%

Scientific Opinion on Bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of Bisphenol A

Flavourings¹

2010

EFSA Journal

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Bisphenol A (BPA) is used in the manufacture of plastics, to produce reusable drinking bottles, infant feeding bottles and other food storage containers. EFSA was asked to evaluate a dietary developmental neurotoxicity study in rats (Stump, 2009) and recent scientific literature (2007)(2008)(2009)(2010) in terms of relevance for the risk assessment of BPA. The impact of these studies on the current Tolerable Daily Intake (TDI) of 0.05 mg BPA/kg body weight (b.w.)/day as set by EFSA in 2006 was assessed. Advice on the Danish risk assessment underlying the Danish ban of BPA in food contact materials for infants aged 0-3 years is included. Overall, based on this comprehensive evaluation of recent toxicity data, the Panel on food contact materials, enzymes, flavourings and processing aids (CEF) concluded that no new study could be identified, which would call for a revision of the current TDI. This TDI is based on the No-Observed-Adverse-Effect-Level (NOAEL) of 5 mg/kg b.w./day from a multi-generation reproductive toxicity study in rats, and the application of an uncertainty factor of 100. This factor is regarded as conservative based on all information on BPA toxicokinetics. The Panel noted that some studies conducted on developing animals have suggested other BPA-related effects of possible toxicological relevance, in particular biochemical changes in brain, immune-modulatory effects and enhanced susceptibility to breast tumours. These studies had several shortcomings. At present the relevance of these findings for human health cannot be assessed. Should any new relevant data become available in the future, the Panel will reconsider this opinion. A minority opinion is expressed by a Panel member and presented in an Annex to this opinion. © European Food Safety Authority, 2010 KEY WORDSBisphenol A, BPA, CAS No. 00080-05-7, developmental toxicity, neurobehaviour, low dose effects. In order to provide a global view on the risk assessment of Bisphenol A, the CEF Panel decided to address the three mandates as given above in a single opinion and postponed the adoption of this comprehensive document to 23 rd September 2010.The three different questions raised by the Commission are dealt with in three different parts (PARTS I to III) of the opinion. PART IV presents an overview of the conclusions from PARTS I to III, together with an overall conclusion. PART IThe GLP compliant study by Stump (2009) was performed according to OECD guideline 426 to address any uncertainty regarding potential neurodevelopmental effects of BPA. BPA was administered daily in the diet at concentrations of 0, 0.15, 1.5, 75, 750, and 2250 mg/kg feed to female Sprague-Dawley rats from gestational day (GD) 0 to postnatal day (PND) 21. The relative estimated intakes (in mg/kg b.w./day) were 0, 0.01, 0.12, 5.85, 56.4 and 164 during gestation and 0, 0.03, 0.25, 13.1, 129 and 410 during lactation. The CEF Panel considers this treatment schedule as relevant to human exposure in utero and via either breastfeeding or infant bottle feeding (in this...

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Bisphenol A in combination with TNF-α selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity

Cited by 46 publications

References 49 publications

Lifetime-Dependent Effects of Bisphenol A on Asthma Development in an Experimental Mouse Model

Lifetime-Dependent Effects of Bisphenol A on Asthma Development in an Experimental Mouse Model

Neither direct nor developmental exposure to bisphenol A alters the severity of experimental inflammatory colitis in mice

Scientific Opinion on Bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of Bisphenol A

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