Bisphenol A in dental sealants and its estrogen like effect

Rathee, Manu; Malik, Poonam; Singh, Jyotirmay

doi:10.4103/2230-8210.95660

Cited by 32 publications

(11 citation statements)

References 28 publications

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“…Due to its advantageous physical and chemical properties including optical clarity, shatter-resistance, light weight, durability, high tensile strength and elasticity in addition to low manufacturing costs, BPA was included in several everyday products. However, although BPA is heat-resistant and only moderately water soluble, its application is controversial, especially regarding food packaging, paper or dentistry products, owing to incomplete polymerization, polymer degradation and seepage out from those materials [3–5]. BPA has been detected in dust and air particles and even in water [6,7], but also in human biofluids [8].…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro

et al. 2015

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Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. Besides its toxic properties, BPA is also well-known for its antioxidant chemical properties. This in vitro study investigated the interference of BPA with interferon-γ (IFN-γ)-induced tryptophan breakdown and neopterin production in human peripheral blood mononuclear cells (PBMC). The pro-inflammatory cytokine IFN-γ induces the conversion of the essential amino acid tryptophan into kynurenine via the enzyme indoleamine-2,3-dioxygenase (IDO-1). In parallel, GTP-cyclohydrolase produces neopterin, a marker of immune activation. A model system of phytohaemagglutinin (PHA)-stimulated PBMC was used to assess potential immunomodulatory properties of BPA. Treatment of cells with BPA [12.5-200μM] resulted in a significant and dose-dependent suppression of mitogen-induced tryptophan breakdown and neopterin formation along with a decrease of IFN-γ levels. Similar but less pronounced effects were observed in unstimulated cells. We postulate that the inhibitory effects of BPA on both T-cell activation and IDO-1 activity that we describe here may be critical for immune surveillance and is likely to influence T helper (Th) type 1/Th2 balance. Such immunosuppressive effects likely contribute to counteract inflammation. Further studies are required to address the in vivo relevance our in vitro findings.

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Section: Introductionmentioning

confidence: 99%

Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro

et al. 2015

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“…Many researches proved the negative side effect of bis-GMA. [17][18][19] Bis-GMA is known as a highly viscous monomer, makes difficult to be handled. The current research had the objectives of replacement the matrix of bis-GMA based to HDDMA based in FRCs and evaluate their residual monomer content.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 Cell toxicity was observed at bis-GMA concentrations of 50 pg/ml and higher. 19 In fact, recent commercial matrix system of FRCs used bis-GMA system as the basic matrix component. To reduce the harmfully effect of such matrix system, it is necessary to look for a new saver matrix system for human instead of bis-GMA.…”

Section: Introductionmentioning

confidence: 99%

Evaluation on Residual Monomer of Hddma Matrix System on Fider Reinforced Condosites (Frc)

et al. 2014

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Matrix system used bis-GMA was reported hazardously. An alternative monomer such as 1,6-hexanediol dimethacrylate(HDDMA) was under research. The aim of this study was to evaluate residual monomer content of HDDMA basedmatrix compositions on FRCs (fiber-reinforced composites). Three monomers based on bis-GMA (Sigma-Aldrich,USA),methylmethacrylate (MMA, ProSciTech, Australia), HDDMA (Esstech, USA) were used and also camphorquinone (CQ,Esstech, USA), N,N-cyanoethyl methylaniline (CEMA, Esstech, USA), E-glass fibers (StickTech, Finland). The matrixratios (weight %) were 78.4% bis-GMA+19.6% MMA+1.0% CQ+1.0% CEMA (control-group), 78.4% HDDMA+19.6% MMA+1.0% CQ+1.0% CEMA (EXP-1group), and 49.0% HDDMA+49.0% MMA+1.0% CQ+1.0% CEMA(EXP-2group). Samples with fibers embedded in matrix were light-cured then powdered. Powder of 150mg was dilutedin acetonitrile to 10ml. The solution was filtered then injected into HPLC (20µL). Residual monomer content wasevaluated by mobile phase of acetonitrile and water of 7:3, flow rate 1mL/minute. The size of column was C185µ,125mm length, 4mm diameter. UV detection used 275nm. Data were analyzed by ANOVA. The result showed theaverage of residual monomer content (in %) was: 0.02125±0.00018 (control-group), 0.01660±0.00016 (EXP-1group),0.01676±0.00033 (EXP-2group). The ANOVA showed significant difference of monomer content among the groups(p<0.05). The LSD showed significant difference between EXP-1 and control-groups; also between EXP-2 and controlgroups (p<0.05). There was no significant difference between EXP-1 and EXP-2 groups (p>0.05). In conclusion, a resinmatrix system based on HDDMA–MMA (EXP-1 and EXP-2 groups) revealed significant difference of residualmonomer content to bis-GMA–MMA (control-group) system. The HDDMA-MMA matrix system had less residualmonomer content than bis-GMA-MMA.

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“…Although the use of BPA in food containers has now been banned in most countries, this compound remains in production and can be found in a variety of consumer products. BPA was previously considered to be a weak estrogen; however, more recent studies indicate that this compound exhibits similar potency to estradiol in some cellular contexts [24][25][26]. For this reason, BPA was replaced by bisphenol S (BPS) in most countries in the early 2000s [25,27].…”

Section: Examples Of Edcsmentioning

confidence: 99%

Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health

Rumph

Stephens

Martin

et al. 2022

IJERPH

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Over the years, industrial accidents and military actions have led to unintentional, large-scale, high-dose human exposure to environmental contaminants with endocrine-disrupting action. These historical events, in addition to laboratory studies, suggest that exposure to toxicants such as dioxins and polychlorinated biphenyls negatively impact the reproductive system and likely influence the development of gynecologic diseases. Although high-level exposure to a single toxicant is rare, humans living in industrialized countries are continuously exposed to a complex mixture of manmade and naturally produced endocrine disruptors, including persistent organic pollutants and heavy metals. Since minorities are more likely to live in areas with known environmental contamination; herein, we conducted a literature review to identify potential associations between toxicant exposure and racial disparities in women’s health. Evidence within the literature suggests that the body burden of environmental contaminants, especially in combination with inherent genetic variations, likely contributes to previously observed racial disparities in women’s health conditions such as breast cancer, endometriosis, polycystic ovarian syndrome, uterine fibroids, and premature birth.

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Bisphenol A in dental sealants and its estrogen like effect

Cited by 32 publications

References 28 publications

Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro

Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro

Evaluation on Residual Monomer of Hddma Matrix System on Fider Reinforced Condosites (Frc)

Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health

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