Bisphenol A Incorporated into Eggs from Parent Fish Persists for Several Days

Takao, Yuji; Oishi, Mayumi; Nagae, Masaki; Kohra, Shinya; Arizono, Koji

doi:10.1248/jhs.54.235

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…Teleost stress axis functioning is highly conserved, and we have shown previously that the developmental programming of the cortisol stress axis was disrupted by BPA accumulation in eggs in the F1 generation. , To the best of our knowledge, this is the first study to demonstrate BPA impact not only on the plasma stress response but also acute stress-related transcript changes in the liver, muscle, and head kidney of trout in successive generations. The concentrations of BPA reported in trout embryos in the present study are environmentally realistic, as similar BPA concentrations were found in wild fish and zooplankton collected from the BPA-impacted sites. , In addition, recent studies have provided evidence of maternal transfer of BPA from the exposed adult female fish to eggs; , hence, understanding the generational toxicities of maternally deposited BPA is highly relevant from a risk assessment standpoint.…”

Section: Discussionsupporting

confidence: 81%

“…mentally realistic, as similar BPA concentrations were found in wild fish and zooplankton collected from the BPA-impacted sites. 38,39 In addition, recent studies have provided evidence of maternal transfer of BPA from the exposed adult female fish to eggs; 3,6 hence, understanding the generational toxicities of maternally deposited BPA is highly relevant from a risk assessment standpoint.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Bisphenol A (BPA), an organic compound used in the production of plastics and epoxy resins, is ubiquitously distributed in the aquatic environment with mounting evidence of its impact on the endocrine system of animals. , Global production of BPA has increased substantially over the years, and over 500 tons of BPA are released into the environment annually . A large body of work has provided insight into the toxicities of BPA in both aquatic and terrestrial animals. , In addition, maternal transfer of BPA has been reported in humans, rodents, and fish, − but the long-term developmental effects are far from clear. Recent studies have also described that exposure to BPA during critical early developmental periods may lead to stable epigenetic modifications that are passed on to the next generation. , …”

Section: Introductionmentioning

confidence: 99%

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Bisphenol A in Eggs Impairs the Long-Term Stress Performance of Rainbow Trout in Two Generations

Thomas

Birceanu

Sadoul

et al. 2018

Environ. Sci. Technol.

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Salmonids are ecologically, economically, and culturally important fish species in North America, but whether contaminants in the environment play a role in their population decline is unclear. We tested the hypothesis that bisphenol A (BPA) deposition in eggs, mimicking a maternal transfer scenario, compromises the stress axis functioning and target tissues stress response in two generations of a model salmonid species, rainbow trout ( Oncorhynchus mykiss). Eggs were enriched with 0, 4, or 40 ng of BPA, fertilized, and reared in clean water for two generations. The fish were subjected to an acute stressor after a year in both generations to test their stress performances. Trout raised from BPA-enriched eggs showed impaired stressor-mediated plasma cortisol and lactate response in the F1 and F2 generations, respectively. Key genes involved in cortisol biosynthesis in the head kidney, as well as stress- and growth-related transcripts in the liver and muscle, were impacted either in the F1 and/or F2 generations. Our results underscore the long-term impact associated with BPA in eggs, mimicking a maternal transfer scenario, on the stress performance of trout in two generations. The results highlight the need for developing novel biomarkers to predict long-term and generational toxicities in salmonids.

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Section: Discussionsupporting

confidence: 81%

Section: ■ Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bisphenol A in Eggs Impairs the Long-Term Stress Performance of Rainbow Trout in Two Generations

Thomas

Birceanu

Sadoul

et al. 2018

Environ. Sci. Technol.

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“…Parental exposure to BPS can be more important because there might be no excretion mechanism for BPS in the eggs as suggested for BPA. 33 BPA and related compounds are well-known as weak estrogen agonists. 13,34 However, the results of our study indicate that exposure to BPS is associated with changes of sex hormone regulation in HPG axis, and these changes were unlikely due to the effects of BPS as an ER agonist.…”

Section: Discussionmentioning

confidence: 99%

Effects of Bisphenol S Exposure on Endocrine Functions and Reproduction of Zebrafish

Ji¹,

Hong²,

Kho³

et al. 2013

Environ. Sci. Technol.

302

145

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While bisphenol S (BPS) has been frequently detected both in environment and biota, limited information is available on their effects of endocrine system. In the present study, adult zebrafish pairs were exposed to 0.5, 5, and 50 μg/L of BPS for 21 d, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BPS. Egg production and the gonadosomatic index in female fish were significantly decreased at ≥0.5 μg/L BPS. Plasma concentrations of 17β-estradiol were significantly increased in both male and female fish. In male fish, however, significant decreases of testosterone concentration were observed along with up-regulation of cyp19a and down-regulation of cyp17 and 17βhsd transcripts. Parental exposure to BPS resulted in delayed and lesser rates of hatching even when they were hatched in clean water. Continuous BPS exposure in the F1 embryos resulted in worse hatchability and increased malformation rates compared to those without BPS exposure. Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring.

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“…fario ) 5 , 11 , 12 . Moreover, BPA is maternally transferred in fish 13 and this potentially could lead to long-term developmental effects even though the progeny was not exposed to water-borne BPA 14 – 16 . As BPA may bring about heritable epigenetic modifications 17 , early exposure to BPA may have long-term and multigenerational consequences in fish.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A in eggs causes development-specific liver molecular reprogramming in two generations of rainbow trout

Sadoul

Birceanu

Aluru

et al. 2017

Sci Rep

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Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout (Oncorhynchus mykiss), an ecologically and economically important species of fish, reprograms liver metabolism in the offspring and alters the developmental growth trajectory in two generations. Specifically, BPA reduces growth during early development, followed by a catch-up growth post-juveniles. More importantly, we observed a developmental shift in the liver transcriptome, including an increased propensity for protein breakdown during early life stages to lipid and cholesterol synthesis post- juveniles. The liver molecular responses corresponded with the transient growth phenotypes observed in the F1 generation, and this was also evident in the F2 generation. Altogether, maternal and/or ancestral embryonic exposure to BPA affects liver metabolism leading to development-distinct effects on growth, underscoring the need for novel risk assessment strategies for this chemical in the aquatic environment. This is particularly applicable to migratory species, such as salmon, where distinct temporal changes in growth and physiology during development are critical for their spawning success.

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Bisphenol A Incorporated into Eggs from Parent Fish Persists for Several Days

Cited by 9 publications

References 31 publications

Bisphenol A in Eggs Impairs the Long-Term Stress Performance of Rainbow Trout in Two Generations

Bisphenol A in Eggs Impairs the Long-Term Stress Performance of Rainbow Trout in Two Generations

Effects of Bisphenol S Exposure on Endocrine Functions and Reproduction of Zebrafish

Bisphenol A in eggs causes development-specific liver molecular reprogramming in two generations of rainbow trout

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