Bisphenol A induces reactive oxygen species generation in the liver of male rats

Bindhumol, V.; Chitra, K. C.; Mathur, Premendu P.

doi:10.1016/s0300-483x(03)00056-8

Cited by 376 publications

(256 citation statements)

References 23 publications

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“…Similar to our results, the increase in the MDA content in the tissues were not observed in mice, which were intraperitoneally injected with BPA (25 and 50 mg/kg/day for 5 days) despite a marked increase of ROS production [21]. On the other hand, in other studies, BPA has been reported to cause significant increases in lipid peroxidation in the liver of male rats orally exposed to BPA at doses of 0.2, 2.0, and 20 µg/kg/day for 30 days [5] and 25 mg/kg/ day for 50 days [25]. The findings obtained in mammalian studies led us to conclude that the effect of BPA on lipid peroxidation might be changed depending on the experimental design and duration.…”

Section: Discussionmentioning

confidence: 89%

“…Orta and Erkan [31] also reported the protective effect of vitamin C against oxidative damage by fluoride in TM4 Sertoli cells. Furthermore, vitamin C was reported to prevent BPA-induced ROS generation in the liver of male rats [5]. In the present study, an antioxidant concentration of vitamin C (50 µM) was administrated to the culture media, and a protective effect of vitamin C was not observed.…”

Section: Discussionmentioning

confidence: 91%

“…Free radicals and reactive oxygen species (ROS) formed in the cells are scavenged effectively by antioxidant defense system enzymatic and non-enzymatic antioxidants [27]. It has been reported in mammalian studies that BPA caused tissue damage, increasing ROS generation [5]. Studies in the past have mainly focused on the estrogenic potency and reproductive adverse effects of BPA in fish [29,[33][34][35]41].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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In this study, isolated hepatocytes of pearl mullet (Alburnus tarichi) were exposed to bisphenol A (BPA) at concentrations of 25, 50, 100, and 200 µM for 24 h. Moreover, an in vitro antioxidant concentration of vitamin C (50 µM) was administrated to the culture medium along with the BPA exposures. Next, the antioxidant defense system parameters were analyzed. According to the results, the highest concentration of BPA (200 µM) proved to be severely toxic for the cells. The increased activities of superoxide dismutase (SOD) and glutathione-S-transferase (GST), the fluctuated activities of glutathione peroxidase (GPx), and the decreased content of reduced glutathione (GSH) were compared to the control group after the BPA exposures. Vitamin C co-administration was found to cause further increases in the SOD, GPx, and GST activities in some of the experimental groups and vitamin C could not restore the GSH content. Malondialdehyde (MDA) levels were observed to be unaffected in all exposure groups. These results show that BPA causes alterations in the antioxidant defenses of the isolated fish hepatocytes. In addition, vitamin C co-administration along with BPA was found to be non-protective against BPA-induced oxidative stress, consequently, aggravated a negative BPA impact.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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“…Several findings indicate that BPA induces oxidative stress in many organs (Bindhumol et al, 2003;Kabuto et al, 2003). BPA facilitates the production of reactive oxygen species (ROS) and thus results in neuronal damage (Ooe et al, 2005;Lee et al, 2008).…”

Section: Mechanisms Of Bpamentioning

confidence: 99%

Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System

Mizuo¹,

Narita²,

Miyagawa³

et al. 2010

Biomolecules and Therapeutics

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-Bisphenol A (BPA) is one of the most common endocrine disrupters. In the last decade, the number of studies concerning the effects of chronic treatment with BPA on the development of the central nervous system (CNS) has increased. However, little is known about the effects of chronic exposure to BPA on higher brain functions such as memory or psychomotor functions. Here, we report our following findings: (1) Prenatal and neonatal exposure to BPA enhances psychostimulant-induced rewarding effects, results in the up-or downregulation of dopamine receptors, causes memory impairment, and decreases choline acetyltransferase (ChAT) activity. (2) BPA activates astrocytes in vivo and in vitro. These findings suggest that prenatal and neonatal exposure to BPA affects the development of the CNS.

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“…Some studies found that BPA could induce changes in various mechanisms and physiological processes, among which early puberty in females and feminization in male at very low levels (12), high-risk breast and prostate cancer (13), calcium influx induction, which leads to release of prolactin (14), development of hyperglycemia, insulin tolerance and diabetes (15), cardiovascular disease (10), abnormal concentration of Y-glutamyl liver enzymes and alkaline phosphatase (16), according to the switching of the β-pancreatic cells (18), dysfunction of thyroid hormone production (18), increase of reactive oxygen species (19), which are implicated in oxidative stress mechanism and over-regulation of cAMP response element binding protein, which inhibits apoptosis (20).…”

Section: Introductionmentioning

confidence: 99%

Bond Strength of a Bisphenol-A-Free Fissure Sealant With and Without Adhesive Layer under Conditions of Saliva Contamination

et al. 2016

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Dental sealants are important for prevention of carious lesions, if they have good shear strength. The aim of this study was to evaluate the shear bond strength (SBS) of two sealants to saliva-contaminated and non-contaminated enamel with and without an intermediate adhesive layer underneath the sealant. Ninety flat enamel surfaces from human third molars were randomly assigned to 6 groups (n=15): F (control): Fluroshield™ sealant; EWB (control): Embrace™ WetBond™; SB/F: Single Bond adhesive system + F; SB/ EWB, s-SB/F and s-SB/EWB. In the s-SB/F and s-SB/EWB groups, the acid-etched enamel was contaminated with 0.01 mL of fresh human saliva for 20 s. Sealant cylinders were bonded to enamel surface with and without an intermediate adhesive system layer. The shear tests were performed using a universal testing machine (0.5 mm/min). Data were analyzed statistically by Kruskal-Wallis and Mann-Whitney tests (α=0.05). F presented higher mean SBS than EWB in all experimental conditions. The lowest SBS mean was obtained for EWB on contaminated enamel (p<0.05). In conclusion, an adhesive system layer should be used prior to sealant placement, in both dry and saliva-contaminated enamel. F had the best performance in all experimental conditions. EWB sealant showed very low results, but an adhesive layer underneath the sealant increased its SBS even after salivary contamination.

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Bisphenol A induces reactive oxygen species generation in the liver of male rats

Cited by 376 publications

References 23 publications

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System

Bond Strength of a Bisphenol-A-Free Fissure Sealant With and Without Adhesive Layer under Conditions of Saliva Contamination

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