Bisphenol A regulates Snail‐mediated epithelial‐mesenchymal transition in hemangioma cells

Abstract

Hemangioma (HA) can be exposed to bisphenol A (BPA) through direct skin absorption. Although numerous studies indicated that BPA can trigger the progression of cancers, there is no study concerning the effects of BPA on development of HA. Our present study revealed that nanomolar BPA can significantly increase the in vitro migration and invasion of HA cells via induction of epithelial-mesenchymal transition (EMT), which was evidenced by the upregulation of vimentin and downregulation of E-cadherin. The BPA treatment also significantly increased the expression and nuclear localization of Snail and the key transcription factor of EMT, while it had no effect on the expression of other transcription factors such as Slug, Twist, or ZEB1. Silencing of Snail by small interfering RNAs attenuated BPA-induced downregulation of cadherin and upregulation of vimentin, suggesting that Snail is essential for BPA-induced EMT. Both estrogen receptor α (ERα) and G protein-coupled estrogen receptor (GPER) were expressed in HA cells; furthermore, BPA treatment can increase the expression of both ERα and GPER. However, only the inhibitor of ERα (ICI 182, 780), and not GPER (G15), can abolish BPA-induced upregulation of Snail. It suggested that ERα is involved in BPA-induced EMT of HA cells. Collectively, our data suggested that BPA can trigger the EMT of HA cells via ERα/Snail signals. It indicated that more attention should be paid to the skin exposure to BPA for HA patients.

Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL‐6

“…This was consistent with recent studies that GPER can mediate the proliferative and migration effects of BPA in cancer cells . Other studies also indicated that ERα is also involved in the biological functions of BPA . The family of estrogen‐related receptor (ERR) is suggested to have a very high bind affinity to BPA, whether ERR was involved in BPA‐triggered promotion of LSCC needs further investigations.…”

Basic Fibroblast Growth Factor is Involved in Bisphenol S Induced Proliferation of Hemangioma Cells

“…Recent studies indicated that BPA can increase the progression of HA via induction of EMT and upregulation of Snail (Zhai et al, 2016). Our present study found that BPS, the "safety" analog of BPA, can trigger the proliferation of HA cells and its cell cycle transition via upregulation of bFGF.…”

“…BPS also has a comparable estrogenic activity as BPA (Kuruto-Niwa et al, 2005). It can induce epithelial-mesenchymal transition (EMT) in HA cells via induction of Snail (Zhai et al, 2016). While the potential effects of BPS on the progression of HA are not investigated.…”

Estradiol promotes epithelial‐to‐mesenchymal transition in human benign prostatic epithelial cells

“…Our previous research recognized EMT as a crucial event in prostate tissues collected from human BPH patients and rat BPH prostates, respectively. Other reports have also noted that E2 promoted the EMT process in several tissue types . However, the exact effect of E2 on EMT in benign prostatic epithelial cells remains undefined.…”