2020
DOI: 10.1186/s12940-020-00620-y
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Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data

Abstract: Concerns about the effects of bisphenol A (BPA) on human brain and behavior are not novel; however, Grohs and colleagues have contributed groundbreaking data on this topic in a recent issue of Environmental Health. For the first time, associations were reported between prenatal BPA exposure and differences in children's brain microstructure, which appeared to mediate the association between this exposure and children's behavioral symptoms. Findings in numerous previous mother-child cohorts have pointed in a si… Show more

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Cited by 54 publications
(31 citation statements)
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“…Exposure to bisphenols has been shown to affect, for example, neurodevelopment in many animal studies [ 28 ], and epidemiological studies are supporting these experimental findings. For example, prenatal BPA exposure has been repeatedly associated with changes in child neurobehavior [ 29 ], and prenatal BPF exposure has been associated with lower cognition in childhood [ 22 ]. In addition, rats exposed to BPA in utero displayed disrupted expression of genes involved in Alzheimer’s disease [ 30 ], and rat brain capillaries exposed to BPA ex vivo showed a decreased BCRP function [ 31 ].…”
Section: Introductionmentioning
confidence: 99%
“…Exposure to bisphenols has been shown to affect, for example, neurodevelopment in many animal studies [ 28 ], and epidemiological studies are supporting these experimental findings. For example, prenatal BPA exposure has been repeatedly associated with changes in child neurobehavior [ 29 ], and prenatal BPF exposure has been associated with lower cognition in childhood [ 22 ]. In addition, rats exposed to BPA in utero displayed disrupted expression of genes involved in Alzheimer’s disease [ 30 ], and rat brain capillaries exposed to BPA ex vivo showed a decreased BCRP function [ 31 ].…”
Section: Introductionmentioning
confidence: 99%
“…The association between maternal BPA exposure and child neurodevelopment has been investigated by several studies (reviewed in [33][34][35]). To the best of our knowledge, five studies have investigated the association between prenatal exposure to BPA and social impairment or autism-symptoms [26,27,30,31,43].…”
Section: Discussionmentioning
confidence: 99%
“…Three studies found no association between prenatal BPA exposure and behaviour [ 30 32 ]. The inconsistencies may be explained by methodological differences between studies, the time window of exposure assessment, the specific behavioural domains tested, the matrix of exposure assessment (urine sample or cord blood), child age (2–10 years), exposure level, and sociodemographic characteristics of the study participants [ 33 35 ].…”
Section: Introductionmentioning
confidence: 99%
“…The animal research literature is also consistent here: numerous studies in rodents have reported a link between exposure to BPA and behaviour ( Anderson et al, 2013 ; Ishido et al, 2011 ; Komada et al, 2014 ; Nakagami et al, 2009 ; Palanza et al, 2008 ; Rochester et al, 2018 ; Tian et al, 2010 ). Moreover, in vitro and in vivo studies provide evidence that BPA can affect biological pathways crucial for normal brain development by binding oestrogen receptors or interacting with the thyroid hormone and hypothalamic-pituitary-adrenal axis ( Mustieles et al, 2015 ; Mustieles and Fernández, 2020 ; Nesan et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%