2020
DOI: 10.1016/j.celrep.2020.108170
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Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia

Abstract: Highlights d Inactivation of BPGM protects against malaria d Protection is linked to increased erythropoiesis after parasite-induced hemolysis d Reduced ATP levels in mutant erythrocytes reduces parasite replication

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Cited by 7 publications
(8 citation statements)
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“…Altogether, 57 genes demonstrated strong expression patterns (±4‐fold change), including frizzled class receptor 10 FZD10 (+16.20‐fold change), a primary receptor for Wnt signaling, leucine rich repeat and Ig domain containing 3 LINGO3 (+5.35‐fold change), which has been shown to regulate mucosal tissue regeneration in humans and promote wound healing, adenosine deaminase (ADA) (−8.17‐fold change), associated with hemolytic anemia, and hepatic leukemia factor HLF (−5.64‐fold change), known to influence the renewal of hematopoietic stem cells (Chen & Mitchell, 1994; Komorowska et al., 2017; Wang et al., 2016; Zullo et al., 2021). In fumigated nestlings, only two genes were upregulated in the urban location: bisphosphoglycerate mutase BPGM (+3.24‐fold change), a regulator of erythrocyte metabolism and hemoglobin in red blood cells, and zinc finger protein GLIS1 (+3.40‐fold change), which has been significantly associated with bill length (Lundregan et al., 2018; Xu et al., 2020). There were no significantly downregulated genes.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Altogether, 57 genes demonstrated strong expression patterns (±4‐fold change), including frizzled class receptor 10 FZD10 (+16.20‐fold change), a primary receptor for Wnt signaling, leucine rich repeat and Ig domain containing 3 LINGO3 (+5.35‐fold change), which has been shown to regulate mucosal tissue regeneration in humans and promote wound healing, adenosine deaminase (ADA) (−8.17‐fold change), associated with hemolytic anemia, and hepatic leukemia factor HLF (−5.64‐fold change), known to influence the renewal of hematopoietic stem cells (Chen & Mitchell, 1994; Komorowska et al., 2017; Wang et al., 2016; Zullo et al., 2021). In fumigated nestlings, only two genes were upregulated in the urban location: bisphosphoglycerate mutase BPGM (+3.24‐fold change), a regulator of erythrocyte metabolism and hemoglobin in red blood cells, and zinc finger protein GLIS1 (+3.40‐fold change), which has been significantly associated with bill length (Lundregan et al., 2018; Xu et al., 2020). There were no significantly downregulated genes.…”
Section: Resultsmentioning
confidence: 99%
“…A with hemolytic anemia, and hepatic leukemia factor HLF (−5.64-fold change), known to influence the renewal of hematopoietic stem cells (Chen & Mitchell, 1994;Komorowska et al, 2017;Wang et al, 2016;Zullo et al, 2021). In fumigated nestlings, only two genes were upregulated in the urban location: bisphosphoglycerate mutase BPGM (+3.24-fold change), a regulator of erythrocyte metabolism and hemoglobin in red blood cells, and zinc finger protein GLIS1 (+3.40fold change), which has been significantly associated with bill length (Lundregan et al, 2018;Xu et al, 2020). There were no significantly downregulated genes.…”
Section: Differentially Expressed Genesmentioning
confidence: 99%
“…Altogether, 57 genes demonstrated strong expression patterns (± 4-fold change), including frizzled class receptor 10 FZD10 (16.20-fold change), a primary receptor for Wnt signaling, leucine rich repeat and Ig domain containing 3 LINGO3 (5.35-fold change), which has been shown to regulate mucosal tissue regeneration in humans and promote wound healing, adenosine deaminase ADA (-8.17-fold change), associated with hemolytic anemia, and hepatic leukemia factor HLF (-5.64-fold change), known to influence the renewal of hematopoietic stem cells (Wang et al, 2016; Zullo et al, 2021; Chen & Mitchell, 1994; Komorowska et al, 2017). In fumigated nestlings, only two genes were up-regulated in the urban site, bisphosphoglycerate mutase BPGM (3.23-fold change), a regulator of erythrocyte metabolism and hemoglobin in red blood cells, and zinc finger protein GLIS1 (3.40-fold change), which has been significantly associated with bill length (Xu et al, 2020; Lundregan et al, 2018). There were no significantly down-regulated genes in fumigated urban nestlings.…”
Section: Resultsmentioning
confidence: 99%
“…However, an inhibitory effect also on parasite enolase was not unequivocally ruled out, so the interaction mechanism was not clearly established. Xu et al. (2020) reported that mice suffering from BPGM deficiency, the enzyme responsible for the synthesis of 2,3-BPG, show severely reduced 2,3-BPG levels and protection against severe malaria-induced anemia and intensity of neuroinflammation on experimental cerebral malaria.…”
Section: Discussionmentioning
confidence: 99%
“…However, an inhibitory effect also on parasite enolase was not unequivocally ruled out, so the interaction mechanism was not clearly established. Xu et al (2020) reported that mice suffering from BPGM deficiency, the enzyme responsible for the synthesis of 2,3-BPG, show severely reduced 2,3-BPG levels and protection against severe malaria-induced anemia and intensity of neuroinflammation on experimental cerebral malaria. The authors suggest that the reduced 2,3-BPG levels results in increased O 2 -bound hemoglobin, decreased oxygen delivery to tissues and compensatory erythropoiesis, which leads to protection against anemia.…”
Section: Discussionmentioning
confidence: 99%