Bisphosphonate-induced osteonecrosis of the jaw: a review of 2,400 patient cases

Filleul, Olivier; Crompot, Emerence; Saussez, Sven

doi:10.1007/s00432-010-0907-7

Cited by 258 publications

(218 citation statements)

References 22 publications

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“…Bisphosphonates, which are prescribed in association with prolonged corticosteroid treatment (with a T score less than Ϫ1.5) to prevent osteoporosis or to treat corticosteroidinduced osteoporosis, may result in jaw osteonecrosis (19,45).…”

Section: Resultsmentioning

confidence: 99%

Recommendations for the care of oral involvement in patients with systemic sclerosis

Alantar¹,

Cabané²,

Hachulla³

et al. 2011

Arthritis Care & Research

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Objective. To review the literature and collect expert advice for proposing preventive and curative treatments of mouth and dental involvement in patients with systemic sclerosis (SSc; scleroderma). Methods. The literature pertaining to mouth and/or dental involvement related to SSc was reviewed, and recommendations were developed according to the suggestions of a French multidisciplinary working group of experts and validated by a lecture committee. Results. Dentists face 3 main issues in caring for SSc patients: oral mucosa involvement, manducatory apparatus and mouth involvement responsible for limitations in mouth opening, and treatment-related adverse events. An increased risk of tongue carcinoma has been noted. In patients with severe limitation in mouth opening (<30 mm), recommended treatments are a specific mouth-opening rehabilitation program, flexible sectional dentures, and splint therapy. Indications for dental implants depend on the severity of SSc, comorbidities, and/or ongoing bisphosphonate treatment. Prevention of mouth infections and caries implies patient education and teaching about mouth and dental hygiene, periodontal maintenance, and treatment of sicca syndrome. Cessation of tobacco use is mandatory. Patient-tailored rehabilitation may improve limitations in mouth opening. Systematic dental panoramic radiography allows for the early detection of dental caries. Conclusion. Prevention of oral and dental complications is a major issue in patients with SSc. Dental treatment should be tailored to limitations in mouth opening, disease severity, and ongoing treatments.

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Section: Resultsmentioning

confidence: 99%

Recommendations for the care of oral involvement in patients with systemic sclerosis

Alantar¹,

Cabané²,

Hachulla³

et al. 2011

Arthritis Care & Research

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“…Thérapeutiques expérimentales • Utilisation du laser Elle représente 14 % des thérapeutiques expérimentales selon Filleul et al [29]. Certains auteurs préconisent une approche chirurgicale dont le but est d'obtenir une fermeture muqueuse pérenne et donc un isolement de l'os par rapport à la cavité buccale, évitant ainsi les surinfections secondaires [5].…”

Section: Traitements Et Prévention Des Onmunclassified

“…• Utilisation de plasma riche en plaquettes (platelet-rich plasma -PRP) [32,33] Elle représente 4 % des thérapeutiques expérimentales selon Filleul et al [29]. Compte tenu de la structure des plaquettes et de leur capacité à interagir avec leur environnement cellulaire, le PRP favorise la cicatrisation.…”

Section: Traitements Et Prévention Des Onmunclassified

“…Le fait d'amener directement les plaquettes sur le site permet de créer un environnement local propice à la régénération tissulaire [34]. [29]. L'application d'ozone sur l'os nécrosé ou sur les sites d'extraction pendant ou après la réalisation du geste chirurgical invasif permettrait de stimuler la prolifération cellulaire et la cicatrisation tissulaire [9].…”

Section: Traitements Et Prévention Des Onmunclassified

“…• Oxygénothérapie hyperbare Elle représente 70 % des techniques expérimentales selon Filleul et al [29].…”

Section: Traitements Et Prévention Des Onmunclassified

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Intérêt de l’oxygénothérapie hyperbare dans la prévention et le traitement des ostéonécroses des maxillaires dues aux bisphosphonates

Gunepin

Derache

Cathelinaud

et al. 2013

Med Buccale Chir Buccale

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Résumé -Les bisphosphonates (BP) sont des inhibiteurs du remodelage osseux indiqués dans la prise en charge de pathologies malignes (myélome multiple, métastases de tumeurs solides, etc.) et bénignes (ostéoporose, maladie de Paget, etc.). Depuis 2003, un effet indésirable imputé à cette classe de médicaments est apparu dans la littérature : les ostéonécroses des maxillaires (ONM) induites par la prise de BP. Cliniquement, l'ONM se caractérise par une exposition d'os nécrotique qui persiste pendant plus de 8 semaines. En 2007, puis 2009, l'American Association of Oral and Maxillofacial Surgeons (AAOMS) a émis des recommandations destinées aux professionnels de santé pour prévenir et prendre en charge cet effet indésirable. Cependant, l'absence de thérapeutiques efficaces a poussé de nombreux auteurs à tester, en complément des thérapies proposées par l'AAOMS, des traitements expérimentaux au nombre desquels figure l'oxygénothérapie hyperbare (OHB). D'un point de vue théorique, l'étiopathogénie des ONM n'étant pas connue, l'impact de l'OHB sur les mécanismes de survenue de cette pathologie reste hypothétique. D'un point de vue clinique, les avis divergent sur l'intérêt de l'utilisation de l'OHB dans le traitement des ONM. Cependant, les résultats préliminaires de deux essais cliniques contrôlés et randomisés en cours aux Etats-Unis laissent à penser que l'OHB pourrait trouver de nouvelles indications en chirurgie orale dans le traitement mais aussi la prévention des ONM.Abstract -Interest of hyperbaric oxygen therapy in the prevention and treatment of bisphosphonate-related osteonecrosis of the jaws. Bisphosphonates (BP) have been used since 1960s for their capability to alter the mechanism of bone resorption and remodeling. Intravenous (IV) BP are effective in the treatment and management of cancer-related conditions including hypercalcemia of malignancy, skeletal-related events associated with bone metastases in the context of solid tumors such as breast cancer, prostate cancer and lung cancer, and management of lytic lesions in the setting of multiple myeloma. Oral BP are used to treat osteoporosis and osteopenia. In 2003, oral and maxillofacial surgeons first recognized and reported cases of non-healing exposed bone in the maxillofacial region in patients treated with IV bisphosphonates. This adverse effect was called BONJ for bisphosphonate-related osteonecrosis of the jaws. Clinically, BONJ is defined by an exposed bone in the maxillofacial region that has persisted for more than 8 weeks. So far, the etiopathogenesis of BONJ remains

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External cervical resorption detected via cone‐beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody–associated disease: A case report

Munenaga

Usuda

Ouhara

et al. 2021

Clinical Case Reports

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External cervical resorption may occur in patients with MOG antibody-associated disease. Herein, we present the first case in the literature. Cone-beam computed tomography is useful for the diagnosis of external cervical resorption in patients with MOG antibody-associated disease that would otherwise be undetected via radiography.Myelin oligodendrocyte glycoprotein (MOG) is the main protein component of the myelin sheath in the central nervous system (CNS). 1 MOG antibody-associated disease is a rare, autoimmune disorder that targets MOG, predominantly affecting the myelin in optic neuritis and myelitis, which can lead to vision loss and paralysis. Immunosuppressive therapies, such as steroids treatment, are often required for the treatment of MOG antibody-associated disease. 2,3 However,

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Bisphosphonate-induced osteonecrosis of the jaw: a review of 2,400 patient cases

Cited by 258 publications

References 22 publications

Recommendations for the care of oral involvement in patients with systemic sclerosis

Recommendations for the care of oral involvement in patients with systemic sclerosis

Intérêt de l’oxygénothérapie hyperbare dans la prévention et le traitement des ostéonécroses des maxillaires dues aux bisphosphonates

External cervical resorption detected via cone‐beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody–associated disease: A case report

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