Bisphosphonate Inhibition of bone resorption induced by particulate biomaterial-associated macrophages

Bisphosphonates in bone cement inhibit PMMA particle induced bone resorption

“…13 The addition of EHDP to cocultures of UMR106 cells and monocyte derived macrophages has been found to inhibit the extent of lacunar bone resorption by osteoclasts partly through an effect on macrophage-osteoclast differentiation 15. In this study we have shown that the addition of particles of PMMA containing EHDP to monocyte derived macrophages similarly inhibits PMMA associated macrophage-osteoclast differentiation and bone resorption and that this activity does not affect the viability of cultured cells.…”

“…Bisphosphonates are known to influence osteoclastic bone resorption by a number of means including direct or indirect suppression of osteoclast function, inhibition of osteoclast differentiation, and promotion of osteoclast apoptosis 17-19. We have recently shown that the bisphosphonate compound, disodium ethane-1-hydroxy-1, 1-diphosphonate (etidronate (EHDP)) also known as 1-hydroxyethylidene-1, 1-bisphosphonic acid, can inhibit PMMA induced osteoclast generation and bone resorption 15. In this study we have sought to determine whether mixing bisphosphonates with PMMA bone cement can inhibit wear debris induced osteolysis and provide a possible therapeutic approach to prevent aseptic loosening.…”

Enhancing Alendronate Release from a Novel PLGA/Hydroxyapatite Microspheric System for Bone Repairing Applications

“…This leads to reduction of geranylgeranyl diphosphate required for prenylation of guanosine triphosphate (GTP)-binding proteins, which are essential for osteoclasts activity, so that AL is capable of effectively reducing bone absorption responsible by osteoclasts (31)(32)(33)(34)(35)(36)(37). Generally, there are three mainstream opinions about the origination of osteoclasts: 1) osteoclasts originate from the fusion of monocytes and/or macrophages; 2) monocytes, macrophages and osteoclasts all originate from common progenitor; and 3) osteoclasts are differentiated from macrophages, among which the third one is best acknowledged (38).…”

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

“…These drugs are already successfully used in the treatment of osteoporosis [12]. Bisphosphonates, such as ibandronate [11], EDPH [32], zoledronate [3], TRK-530 [19], and alendronate [43], have been extensively studied and demonstrated their antiresorptive effect.…”