Bisphosphonate-related osteonecrosis of the jaws

Sogacheva, V V; Semkin, V A

doi:10.17116/stomat202210106185

Cited by 4 publications

(5 citation statements)

References 51 publications

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“…A number of morphological studies revealed significant lipid deposits in the arterial intima, which was clinically manifested by increased blood viscosity with signs of progressively developing atherosclerosis. As a result, reparative bone regeneration was impaired due to excessive accumulation of lactic and pyruvic acids, glycosaminoglycans, and deficient blood supply, leading to impaired periosteal metabolism, which, in turn, contributed to the inhibition of normal osteogenesis (Loktionova et al 2022;Sogacheva et al 2022;Martins et al 2023).…”

Section: Resultsmentioning

confidence: 99%

Diagnostic analysis of toxic damage due to a dose of zoledronic acid

Gabbasova,

Sletova,

Oksentyuk

et al. 2023

RRP

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Introduction: Comprehensive analysis is necessary to analyze the widespread use of bisphosphonate drugs in the treatment and prevention of various diseases of connective tissue structures. The relevance of the study depends on the impact they have on the patient’s somatic condition, given the number of early and late complications diagnosed by domestic and foreign clinicians. Materials and methods: The methodology used was developed on Stavropol Regional Clinical Hospital from 2010 to 2022. A randomized and observational study of the state of connective tissue structures was conducted in 186 patients who had a history of taking zoledronic acid and developed bisphosphonate osteonecrosis of the jawbone. At the diagnostic and treatment stages, patients were tested using laboratory methods to monitor amino acids in biological fluids (blood), as well as bone blocks extracted intraoperatively using highly effective gas-liquid chromatography on AAA 500. Results and discussion: Aminograms obtained in the pre-operative period indicate toxic effects of zoledronic acid on neuro, endocrine, and other human systems. The initiation and progression of aseptic inflammatory processes in tissue structures is correlated with the deteriorating general ocular status of patients when amino acids, such as alanine, serine, taurine, phenylalanine, tyrosine, proline, histidine, glycine, and valine, against a background of 90.4±2.1 mmol/L ammonia are reduced critically. Conclusion: Zoledronic acid initiates an aseptic chronic inflammatory process in the jaw bones, accompanied by toxic acidosis, which worsens osteoporotic symptoms.

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Section: Resultsmentioning

confidence: 99%

Diagnostic analysis of toxic damage due to a dose of zoledronic acid

Gabbasova,

Sletova,

Oksentyuk

et al. 2023

RRP

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“…An increased CPK usually indicates muscle damage. The increase was observed only in the placebo Group, in the 12h postoperative period, signaling the process of tissue necrosis, while the LPL and MAC Groups maintained normal levels at all times [2][3][4].…”

Section: Major Findings On the Osteonecrosis Of The Jawsmentioning

confidence: 88%

“…Thus, these drugs can reveal several adverse effects, among them osteonecrosis of the jaws, which affects 0.01% to 0.04% of patients who use the drug orally, however, although complications are rare when they occur they are severe. and mutilating, impairing the quality of life of these individuals [1][2][3][4]. According to the AAOMS Guideline, the clinical treatment of Osteonecrosis consists of improving the signs and symptoms, with anti-inflammatories, antibiotic therapy, analgesics, and irrigation with chlorhexidine, which can last for months, aggravating the local conditions.…”

Section: Major Findings On the Osteonecrosis Of The Jawsmentioning

confidence: 99%

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Osteonecrosis of the jaw with the use of bisphosphonates and treatment with laser therapy and magnetotherapy: a concise systematic review

Arede¹,

Beijo²,

Martinez³

et al. 2023

MedNEXT

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Introduction: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been increasing, mainly as a consequence of the treatment of osteoporosis in elderly women. During bone resorption, bisphosphonates (BP) are taken into osteoclasts and exhibit cytotoxicity, producing a long-lasting anti-bone resorptive effect. several energy-based devices have been used with substantial clinical improvement in the treatment. Devices are widely used in various types of treatment, such as LASER, LED, TEMs, infrared devices, Ultrasound, and radiofrequency, among others. Objective: It was to analyze the main findings and weave approaches of scientific evidence of the occurrence of osteonecrosis by the use of bisphosphonates, as well as the possible treatments, highlighting laser therapy and magnetotherapy. Methods: The present study was followed by a systematic review model (PRISMA). The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The Cochrane Instrument was used to assess the risk of bias from the included studies. The present study was carried out from December 2022 to March 2023. Results and Conclusion: A total of 138 articles were found. Initially, duplicate articles were excluded. After this process, the abstracts were evaluated and a new exclusion was performed based on the GRADE Instrument and Risk of Bias. A total of 58 articles were fully evaluated and 26 were included and discussed in this study. It was concluded that photobiomodulation therapy and magnetotherapy showed safety and efficacy in the treatment of BRONJ, through the reduction of phlogistic signs, faster healing, and reduction of postoperative morbidity. Only four applications of low-intensity laser and magnetotherapy were enough to reduce the inflammatory process in the surgical wound, stimulate the tissue repair process and provide postoperative analgesia.

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“…Adjuvant chemotherapy, surgery, and targeted therapy with phosphonates also achieve better therapeutic results [49] , [50] , [51] , [52] , [53] . However, there are also serious side effects that affect the quality of life of patients, such as osteonecrosis of the jaw and heart damage [54] , [55] , [56] .…”

Section: Discussionmentioning

confidence: 99%