Bisphosphonate-related osteonecrosis of the jaws and dental surgery procedures in children and young people with osteogenesis imperfecta: A systematic review

Contaldo, María; Luzzi, Valeria; Ierardo, Gaetano; Raimondo, Eugenio; Boccellino, Mariarosaria; Ferati, Kenan; Bexheti-Ferati, Arberesha; Inchingolo, Francesco; Domenico, Marina Di; Serpico, Rosario; Polimeni, Antonella; Bossù, Maurizio

doi:10.1016/j.jormas.2020.03.003

Cited by 22 publications

(17 citation statements)

References 40 publications

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“…Further studies aiming to rate the genetic risk for periodontitis have focused on molecular levels of IL-1, IL-6, TNF-α, Vitamin-D receptor, Fc-gamma receptor, IL-10, and matrix metalloproteinase [170,171]. e interest in the determination of the diagnostic value of metalloproteinases, in fact, is well known not only in periodontal diseases [172] but also in caries, pulp, and periapical inflammations [173,174] and some cancers [175][176][177]. Moreover, other authors focused on genetic disorders related to periodontitis, since several syndromes, such as Chèdiak-Higashi, trisomy 21, Ehlers-Danlos, Papillon-Lefèvre, Haim-Munk, leukocyte adhesion deficiency (LAD), and lazy leukocyte syndrome, show a periodontal disease history, due to anomaly in aggregation and action of neutrophils [178].…”

Section: Relationship Between Genetic and Epigenetic Changes Inmentioning

confidence: 99%

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Contaldo

Boccellino

Zannini

et al. 2020

Journal of Oncology

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Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.

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Section: Relationship Between Genetic and Epigenetic Changes Inmentioning

confidence: 99%

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Contaldo

Boccellino

Zannini

et al. 2020

Journal of Oncology

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“…The mouth is the opening tract of the digestive system, and its unhealthy state has been bi-directionally associated with various systemic and gastro-intestinal diseases [ 1 , 2 , 3 , 4 , 5 ]. For example, atrophic glossitis and angular cheilitis may underlie Plummer–Vinson syndrome—a sideropenic dysphagia secondary to iron deficiency associated with gastric ulcerations [ 6 ] as well as pernicious anemia, which is due to the failure of the gastric cells to produce the intrinsic factor responsible for the absorption of vitamin B12 in the intestine [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Microbiota and Salivary Levels of Oral Pathogens in Gastro-Intestinal Diseases: Current Knowledge and Exploratory Study

et al. 2021

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Various bi-directional associations exist between oral health and gastro-intestinal diseases. The oral microbiome plays a role in the gastro-intestinal carcinogenesis and fusobacteria are the most investigated bacteria involved. This paper aims to review the current knowledge and report the preliminary data on salivary levels of Fusobacterium nucleatum, Porphyromonas gingivalis and Candida albicans in subjects with different gastro-intestinal conditions or pathologies, in order to determine any differences. The null hypothesis was “subjects with different gastro-intestinal diseases do not show significant differences in the composition of the oral microbiota”. Twenty-one subjects undergoing esophagastroduodenoscopy or colonscopy were recruited. For each subject, a salivary sample was collected before the endoscopy procedure, immediately stored at -20°C and subsequently used for genomic bacterial DNA extraction by real-time PCR. Low levels of F. nucleatum and P. gingivalis were peculiar in the oral microbiota in subjects affected by Helicobater pylori-negative chronic gastritis without cancerization and future studies will elucidate this association. The level of C. albicans did not statistically differ among groups. This preliminary study could be used in the future, following further investigation, as a non-invasive method for the search of gastrointestinal diseases and associated markers.

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“…Furthermore, since bisphosphonate (BP) treatment remains the first line medical management, particular attention should be paid to the risk of developing osteonecrosis of the jaw (ONJ) and the management of this possible complication [ 26 , 27 , 28 ]. However, the literature confirmed the lack of BP-related ONJ occurrence in the pediatric population suffering OI and treated with BP [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Dentinogenesis Imperfecta and Caries in Osteogenesis Imperfecta among Vietnamese Children

Nguyen

et al. 2021

Dentistry Journal

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Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility and low bone mass, caused mainly by mutations in collagen type I encoding genes. The current study aimed to evaluate dentinogenesis imperfecta (DI), oral manifestations and caries status of OI children. Sixty-eight children (41 males, 27 females) aged from 3 to 17 years old (mean 9 ± 4.13) participated in the study. Participants were classified into three OI type groups (I—2 cases, III—31 cases and IV—35 cases). Clinical examination and an orthopantomogram were used to obtain prevalences and associations of DI, caries status, malocclusion, crossbite, open bite, eruption, impaction and missing teeth with OI. The prevalence of DI among OI patients was 47.1%, more common in OI type III than type IV. The yellow-brown discoloration type was more vulnerable to attrition than the opalescent-grey one in the primary dentition. OI seemed not to have a high risk of caries; the prevalence of caries was 69.1%. A high incidence of malocclusion, crossbite and open bite was observed. In-depth oral information would provide valuable data for better dental management in OI patients. Parents and general doctors should pay more attention to dental care to prevent caries and premature tooth loss.

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Bisphosphonate-related osteonecrosis of the jaws and dental surgery procedures in children and young people with osteogenesis imperfecta: A systematic review

Cited by 22 publications

References 40 publications

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Oral Microbiota and Salivary Levels of Oral Pathogens in Gastro-Intestinal Diseases: Current Knowledge and Exploratory Study

Dentinogenesis Imperfecta and Caries in Osteogenesis Imperfecta among Vietnamese Children

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