Bisphosphonate-related osteonecrosis of the jaws: A review of 34 cases and evaluation of risk

Dexrazoxane shows cytoprotective effects in zoledronic acid-treated human cells in vitro and in the rabbit tibia model in vivo

“…While this is the basis of the effective working mechanism, it also results in the main side effect of the therapy known as bisphosphonate-related osteonecrosis of the jaw (BRONJ) (Khosla et al, 2007;Kyrgidis and Vahtsevanos, 2011;Marx, 2003;Mast et al, in press;Otto et al, in press;Surgeons, 2007). The problem is described in all areas of use and in oral as well as i.v.…”

“Bisphosphonates: Possible Modes of Action and Implications for Dental Implant Treatment. A Review of the Literature”

“…Numerous studies have examined the effects of bisphosphonates on fibroblasts, epithelial cells, and endothelium [30][31][32][116][117][118], investigated the effects of pamidronate and zoledronate, on primary human gingival fibroblasts. They used physiologically relevant levels of bisphosphonate determined by expected bone concentrations of bisphosphonates from animal studies.…”