Bisphosphonate therapy in chronic diffuse sclerosing osteomyelitis/tendoperiostitis of the mandible: Retrospective case series

Meent, Marieke M. van de; Appelman‐Dijkstra, Natasha M.; Wetselaar‐Glas, Miranda J.M.; Pichardo, Sarina E.C.; Merkesteyn, J.P.R. van

doi:10.1016/j.jcms.2022.05.011

Cited by 5 publications

(7 citation statements)

References 33 publications

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“…In the study by Van de Meent et al . 29 , a reduction in activity was noted in seven patients, no activity in two patients, no change in one patient, and an increase in activity in one patient post-bisphosphonate therapy. Finally, in the study by Montonen et al .…”

Section: Resultsmentioning

confidence: 87%

“…Furthermore, 76.7% of patients developed hypocalcaemia which typically occurred on the second day of treatment, and 14% of patients developed hypokalaemia which typically occurred on day three of treatment. In the study by van de Meent et al 29 , six of the eighteen patients reported an acute phase reaction, with transient complaints of headache, fever, and flu-like symptoms. Sælen et al 30 reported that only one out of the eight patients treated developed influenza like symptoms.…”

Section: Resultsmentioning

confidence: 99%

“…The study by van de Meent et al . took the former approach, identifying that no patient reported trismus following bisphosphonate therapy 29 . Similarly, Kuijpers et al .…”

Section: Resultsmentioning

confidence: 99%

“…In the study by Van de Meent et al . 29 , panoramic radiographs and cone beam computed tomography (CBCT) were performed on patients post-bisphosphonate therapy. On the panoramic radiographs post-bisphosphonate therapy, an almost normal bone architecture was described in two patients, an improvement was described in seven patients, and deterioration was described two patients in the form of increased lysis and/or extension of the disease.…”

Section: Resultsmentioning

confidence: 99%

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Bisphosphonate therapy in the management of diffuse sclerosing osteomyelitis of the mandible: a systematic review and narrative synthesis

Abukhder,

Nasri Elmi,

Van Der Lith

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Diffuse Sclerosing Osteomyelitis (DSO) affecting the mandible is an uncommon condition characterized by recurrent pain and functional disturbances. Traditional treatments involving antibiotics, steroids, and analgesics have generally yielded unsatisfactory results. Numerous articles have proposed the utilization of bisphosphonate therapy as an alternative approach to achieve sustained symptom relief. This study aims to consolidate the available evidence on the effectiveness of bisphosphonate therapy in managing DSO. Methods: A systematic review protocol was registered with PROSPERO and reported in accordance with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses. Comprehensive electronic search strategies were devised, and studies were screened based on predefined inclusion and exclusion criteria. Results: Ten articles met the eligibility criteria, encompassing a total of 135 patients diagnosed with DSO who received bisphosphonate treatment. All included studies consistently reported a reduction in pain levels and swelling, along with a decrease in the cumulative use of analgesics. The majority of patients reported long-lasting symptom improvement with bisphosphonate therapy. Notably, four studies documented improvements in maximal mouth opening, with one study reporting a mean increase of 9.6mm. Furthermore, six studies observed improvements in panoramic radiographs and cone beam CT scans, with one publication describing two patients exhibiting near-normal bone architecture. Importantly, all studies reported the absence of long-term complications. Conclusions: Bisphosphonate therapy emerges as a promising treatment modality for DSO, exhibiting efficacy in symptom alleviation and radiological enhancement while conferring lasting benefits. Nevertheless, further prospective studies are warranted to refine treatment protocols and substantiate these findings.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

“…The study by van de Meent et al . took the former approach, identifying that no patient reported trismus following bisphosphonate therapy 29 . Similarly, Kuijpers et al .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Bisphosphonate therapy in the management of diffuse sclerosing osteomyelitis of the mandible: a systematic review and narrative synthesis

Abukhder,

Nasri Elmi,

Van Der Lith

et al. 2023

Annals of Medicine &Amp; Surgery

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“…This case series described techniques for remodelling surgery in patients with DSO/TP of the mandible, that experienced residual mandibular deformity (i.e. facial asymmetry) after their DSO complaints had been successfully treated using non-surgical treatment options (conservative treatment and/or bisphosphonate therapy) ( 7 , 8 , 10 ). The patients in this case series had therefore been free of DSO complaints for more than six months.…”

Section: Discussionmentioning

confidence: 99%

Remodelling surgery with 3D printed patient specific surgical guides in patients with chronic diffuse sclerosing osteomyelitis/tendoperiostitis of the mandible, a case series

Meent,

Ende,

Pichardo

et al. 2024

Med Oral

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Background Patients with chronic diffuse sclerosing osteomyelitis/tendoperiostitis (DSO/TP) of the mandible may complain about facial asymmetry as a result of mandibular deformity, one of the characteristics of DSO/TP of the mandible. If the disease is fully extinguished, remodelling surgery could be performed to treat complaints of facial asymmetry. This study reports the results of remodelling surgery with three-dimensional (3D) designed- and -printed patient-specific surgical guides. Material and Methods 3D printed guides were designed and manufactured by using mirroring of the contralateral non-affected mandible. Subsequently, the surgical procedure was performed under general anaesthesia using these surgical guides. Results Four patients (all female) aged 15 (±2.8) years were included. They all complained about facial asymmetry and were planned for surgery with patient-specific surgical guides. Three of those surgeries were performed, of which two patients were satisfied with the result and the other patient is planned for re-surgery because of persistent aesthetical complaints. The last patient cancelled her surgery, because she eventually accepted her asymmetry with the help of a psychologist. Conclusions The use of patient-specific surgical guides in remodelling surgery of the mandible could enable a more predicTable and symmetrical outcome, which could minimise the chance for re-surgery and could increase patient satisfaction. Furthermore, it could minimise the chance of iatrogenic damage to the inferior alveolar nerve. Key words: Diffuse sclerosing osteomyelitis, chronic tendoperiostitis, pain, surgery, remodelling, 3D.

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Osteomyelitis der Kieferknochen

Ristow,

Otto

2024

MKG-Chirurgie

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Bisphosphonate therapy in chronic diffuse sclerosing osteomyelitis/tendoperiostitis of the mandible: Retrospective case series

Cited by 5 publications

References 33 publications

Bisphosphonate therapy in the management of diffuse sclerosing osteomyelitis of the mandible: a systematic review and narrative synthesis

Bisphosphonate therapy in the management of diffuse sclerosing osteomyelitis of the mandible: a systematic review and narrative synthesis

Remodelling surgery with 3D printed patient specific surgical guides in patients with chronic diffuse sclerosing osteomyelitis/tendoperiostitis of the mandible, a case series

Osteomyelitis der Kieferknochen

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